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All Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Jasmine Iskandar
Faculty of Medicine University of Indonesia/ Dr. Cipto Mangunkusumo Hospital Jakarta
Health Professions Medicine & Pharmacology Public Health

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Higher Preoperative Endometrial Cancer Risk Showed More Advanced Stage Iskandar, Jasmine
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 2, April 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (135.837 KB)

Abstract

Objective: To evaluate the preoperative endometrial cancer risk as a guidance to choose the type of surgical approach based on European Society for Medical Oncology guideline (2009). Method: Cross-sectional study involved 73 endometrial cancer patients of Dr. Cipto Mangunkusumo Hospital, from January 2006 to December 2012 which obtained from medical record. The inclusion criteria were endometrial cancer patients with complete D&C, ultrasonographic, and postoperative histopathological reports. Endometrial cancer risk of recurrence was classified according to ESMO 2009 and final diagnosis and stage based on FIGO. Result: From 405 patients, only 73 patients had complete reports. Most of the them were postmenopausal (54.8%), non-nulliparity (79.9%), and obese (49.5%) women. According to risk of recurrence stratification, low, intermediate and high risk were found in 12 patients, 27 patients, and 34 patients. Based on FIGO, there were 60.2% early and 39.8% advanced stage. In high risk group, rates of advanced stage were prominent compared to other groups. There were 38.3% patients with postoperative positive lymph nodes metastases. Conclusion: Most of the endometrial cancer patients were preoperatively diagnosed as high risk. The commonest stage after surgical examination were IIIC. High risk of recurrence showed more positive lymph node compared to low or intermediate risk. Result of preoperative histopathological and myometrial invasion compared to postoperative results were showed to be inconsistent. Patients with ≥ 2 myometrial invasion had more positive lymph nodes metastases. Endometrial cancer risks compared to FIGO stage showed the higher the risk, the more advanced the stage were. [Indones J Obstet Gynecol 2014; 2: 99-105] Keywords: endometrial cancer, FIGO stage, high risk, histological type, intermediate risk, low risk, lymph node.
Accuracy of Intraoperative Frozen Section in Diagnosing Malignancy of Ovarian Neoplasm Utami, Tofan W; Iskandar, Jasmine; Tanamas, Gregorius; Jamtani, Mona; Nuranna, Laila; Nuryanto, Kartiwa H
Indonesian Journal of Obstetrics and Gynecology Volume. 3, No. 3, July 2015
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (86.766 KB) | DOI: 10.32771/inajog.v3i3.47

Abstract

Objective: To evaluate the accuracy of frozen section for ovarian neoplasm in our hospital. Method: A retrospective evaluation was conducted on medical records of patients with ovarian neoplasms who underwent a frozen section laparotomy between the years 2008 and 2013 at Dr. Cipto Mangunkusumo Hospital. Records with incomplete data on frozen section or paraffin block report were excluded. Criteria for frozen section laparotomy in our facility was based on a malignancy score of equal to or more than 6. Frozen section reports were compared to paraffin block report based on benign, borderline, or malignant cases. Result: From 139 patients with ovarian neoplasm, only 91 patients fulfilled the inclusion and exclusion criteria. Frozen section examination revealed benign cases was 15.4%, borderline cases was 15.4%, and malignant cases was 69.2%. Based on histopathological type, clear cell cystoadenocarcinoma was the most commonly observed histotype (19.8%). The sensitivity of frozen section for benign, borderline, and malignancy cases respectively was 81.8%, 76.9%, 91.0%. The specificity of frozen section for benign, borderline, and malignancy case respectively was 93.8%, 94.8%, 91.6%. Conclusion: We found that the accuracy of intraoperative frozen section in our facility is adequate to diagnose ovarian neoplasm and can be used to assist in determining the extent of surgical management. [Indones J Obstet Gynecol 2015; 3: 161-164] Keywords: frozen section, ovarian neoplasm, paraffin block, sensitivity, specitificity
Accuracy of Intraoperative Frozen Section in Diagnosing Malignancy of Ovarian Neoplasm Utami, Tofan W; Iskandar, Jasmine; Tanamas, Gregorius; Jamtani, Mona; Nuranna, Laila; Nuryanto, Kartiwa H
Indonesian Journal of Obstetrics and Gynecology Volume. 3, No. 3, July 2015
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (86.766 KB) | DOI: 10.32771/inajog.v3i3.47

Abstract

Objective: To evaluate the accuracy of frozen section for ovarian neoplasm in our hospital. Method: A retrospective evaluation was conducted on medical records of patients with ovarian neoplasms who underwent a frozen section laparotomy between the years 2008 and 2013 at Dr. Cipto Mangunkusumo Hospital. Records with incomplete data on frozen section or paraffin block report were excluded. Criteria for frozen section laparotomy in our facility was based on a malignancy score of equal to or more than 6. Frozen section reports were compared to paraffin block report based on benign, borderline, or malignant cases. Result: From 139 patients with ovarian neoplasm, only 91 patients fulfilled the inclusion and exclusion criteria. Frozen section examination revealed benign cases was 15.4%, borderline cases was 15.4%, and malignant cases was 69.2%. Based on histopathological type, clear cell cystoadenocarcinoma was the most commonly observed histotype (19.8%). The sensitivity of frozen section for benign, borderline, and malignancy cases respectively was 81.8%, 76.9%, 91.0%. The specificity of frozen section for benign, borderline, and malignancy case respectively was 93.8%, 94.8%, 91.6%. Conclusion: We found that the accuracy of intraoperative frozen section in our facility is adequate to diagnose ovarian neoplasm and can be used to assist in determining the extent of surgical management. [Indones J Obstet Gynecol 2015; 3: 161-164] Keywords: frozen section, ovarian neoplasm, paraffin block, sensitivity, specitificity
Risk of Malignancy Index is not accurate as a Triage Tool for Ovarian Cancer Tanamas, Gregorius; Iskandar, Jasmine; Utami, Tofan W; Anggraeni, Tricia D; Nuryanto, Kartiwa H
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 1, January 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (110.17 KB) | DOI: 10.32771/inajog.v2i1.380

Abstract

Objective: To evaluate Risk of Malignancy Index (RMI) as a triage tool for ovarian cancer in Dr. Cipto Mangunkusumo Hospital. Method: This is a retrospective study conducted from January 2008-December 2012 in patients diagnosed with ovarian mass. Patients admitted for surgery due to ovarian masses were included to this study. RMI 3 score was calculated based on ultrasonography examination in Dr. Cipto Mangunkusumo Hospital, CA-125 test and menopausal status. Patients without final pathological report and incomplete data were excluded from study. Data were analysed using SPSS 20 to evaluate RMI result and final pathlogical report in benign and malignant case. Result: From 882 patients identified with ovarian masses from cancer registry, only 99 patients aged 17-70 y.o were included in this study. Most of the patients were nully-parity (28.3%), non-menopausal women (60.6%), normal body mass index (40.4%), and with stage IIIC ovarian cancer (33.3%). Ultrasonography examination showed that most of patients had solid mass and ascites (19.2%). Meanwhile, CA-125 showed that patients with <35 U/ml were 10.1% and ≥ 35 U/ml were 89.9%. Patients with RMI scores <200 (benign cases) were 19 cases (19.2%) and ≥ 200 (malignant cases) were 80 cases (80.8%). Meanwhile, patients with benign final pathological report were 23 cases (23.2%) and malignant cases were 76 cases (76.8%). There was no statistical difference in RMI between benign and malignant cases based on final pathological report. Conclusion: Our study showed that RMI was not accurate as triage tool for ovarian cancer in our hospital. Further investigation and more patients are needed to confirm this study. Keywords: CA-125, menopausal status, ovarian cancer, risk of malignancy index (RMI), ultrasonography.
Co-Authors Gregorius Tanamas Jamtani, Mona Laila Nuranna Nuryanto, Kartiwa H Tofan W Utami Tricia D Anggraeni