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H Hartono
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Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Health Professions Industrial & Manufacturing Engineering Nursing Public Health

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Perencanaan Kebutuhan Tenaga Kerja pada Perusahaan Jasa Penyeberangan Ujung-Kamal H Hartono
Jurnal Teknik Industri Vol. 9 No. 2 (2008): Agustus
Publisher : Department Industrial Engineering, University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/JTIUMM.Vol9.No2.95-101

Abstract

Employees is the most important need and the first priority corporation. Employees determines the successfully to achieve corporation aims. That’s why to planning employees need we have to doing accurately and precisely. This intended to adapt employees need at this present and future with work load, avoiding allowances, and all works can be optimally covered. This research was doing on crossing company PT. Dharma lautan Utama to analyze of employees need on porter department, vehicle arranger department, and entertainment department. Work load analyze is used to porter department and vehicle arranger department. For entertainment department is used urgently analyze with questionnaire method. From the analyze is got that amount of porter employees and vehicle arranger employees who company hire are over than work load. This circumstances make many allowances and many employees work not optimally. Beside that, there is company policy that’s not appropriate on equipping live singer facility. This facility is wasting because passengers are dislike. If company decrease the amount of employees, (hire employees as need) and changing live singer facility with substitution facility that passengers like (TV and Music), company will be able to minimized operational fare as Rp54.969.000. per month.
STUDI AKTIVITAS HEPATOPROTEKTIF FRAKSI ETIL ASETAT KENIKIR (COSMOS CAUDATUS) PADA TIKUS YANG DIINDUKSI PARASETAMOL KAJIAN STRESS OSIDATIF (LIPID PEROSIDASE) Agil Novianto; H Hartono
Jurnal Kesehatan Kusuma Husada Vol. 7 No. 1, Januari 2016
Publisher : Universitas Kusuma Husada Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (236.927 KB)

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ABSTRAKHati memainkan peran penting dalam metabolisme dan ekskresi. Parasetamol dosis tinggi dapat membuat gagal hati akut (ALF) dan nekrosis di hepar dari penanda enzim serta meningkatkan parameter oksidatif stres untuk peroksidasi lipid. Tujuan penelitian untuk mengetahui efektivitas etyl asetat fraksi kenikir pada tikus yang diinduksi oleh parasetamol. Desain penelitian aktivitas hepatoprotektif menggunakan hewan uji yang terbagi enam kelompok. Kelompok I (normal) diberi asupan aquades, kelompok II (kontrol negatif) diberi CMC 1 %, kelompok III (kontrol positif) diberi kurkuminoid 100mg/kg BB dalam CMC 1 %, kelompok IV-VI (kelompok perlakuan) diberi fraksi etil asetat kenikir dengan dosis 281,25 mg/kg BB, 562,5 mg/kg BB, dan 1.125 mg/kg BB. Perlakuan sediaan uji selama 7 hari, pada hari ke-7, 30 menit setelah pemberian sampel uji dilanjutkan dengan induksi parasetamol dosis 2,5 g/kg BB secara peroral. Setelah 48 jam induksi, selanjutnya dilakukan pembedahan hewan uji untuk pengambilan sampel liver. Sampel jaringan liver digunakan untuk analisis parameter stres oksidatif yaitu lipid peroxidation (LPO). Fraksi etil asetat kenikir dosis 1125 mg/kg BB mampu menghambat terjadinya lipid peroksidasi secara signifikan yaitu memberikan efek optimal hepatoprotektif dan indikasi penurunan peroksidasi lipid (p <0,05). Mekanisme hepatoprotektor fraksi etil asetat kenikir didasarkan atas kemampuan sebagai antioksidan (in vitro dan in vivo) sehingga terjadinya kerusakan liver (nekrosis) dapat diminimalisir.Kata kunci: etylaccetate kenikir fraksi, hepatoprotektif, peroksidasi lipid, parasetamol ABSTRACT The liver plays an important role in the metabolism and excretion. High doses of paracetamol could create acute liver failure (ALF) to show necrosis at high liverby of marker enzymes and increases oxidative stress parameters for example lipid peroxidation. The aim of research to determine the effectiveness etyl acetate fraction of marigolds in rats induced by paractamol. The study design hepatoprotective activity using test animals were divided into six groups. Group I (normal) fed a diet of distilled water, group II (negative control) were given CMC 1%, group III (positive control) were given kurkuminoid 100mg / kg in CMC 1%, group IV-VI (the treatment group) were given a fraction of ethyl acetate kenikir with a dose of 281.25 mg / kg, 562.5 mg / kg, and 1,125 mg / kg. Test preparation treatment for 7 days, on the 7th day, 30 minutes after administration of the test sample followed by induction of paracetamol dose of 2.5 g / kg is orally. After 48 hours of induction, then performed surgery for sampling test animal liver. Liver tissue samples used for the analysis of oxidative stress parameters, namely lipid peroxidation (LPO). Ethyl acetate fraction kenikir dose 1125 mg / kg is capable of preventing the occurrence of lipid peroxidation significantly optimal effect hepatoprotective indicated by a decrease lipid peroxidation (p<0.05). Hepatoprotective mechanism kenikir ethyl acetate fraction is based on the ability of antioxidants (in vitro and in vivo) so that the occurrence of liver damage (necrosis) can be minimized.Keywords: etylaccetate fractions of kenikir, hepatoprotective, lipid peroxidation, paracetamol
Co-Authors Agil Novianto