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All Journal Journal of Food and Pharmaceutical Science Integrated Lab Journal Bioveritas Journal of Biology Journal of Food and Pharmaceutical Sciences
Isma Kurniatanty
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience

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Antihypertension Activity Test oOf Red Ginger (Zingiber officinale Var. Rubrum Roscoe) Ethanol Extract by In Silico Method Risti Zahroh; Isma Kurniatanty; Jumailatus Sholihah; Esti Wahyu Widowati
Journal of Food and Pharmaceutical Sciences Vol 9, No 3 (2021): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.2694

Abstract

Hypertension or high blood pressure is a condition when there is an increase in blood pressure above the normal threshold (> 140/90 mmHg). The bioactive compounds in red ginger are dominated by the terpene group which has the ability to inhibit the action of Angiotensin Converting Enzyme (ACE-inhibitor). The interaction between ACE-inhibitory peptides can be predicted by the in silico method. The in silico method was used to predict the interaction and binding energy between bioactive compounds in red ginger ethanol extract (ligand) and ACE protein (receptor) which acts as an antihypertensive. The results of GC-MS obtained as many as 5 compounds (zingiberene, farnesene, ß -sesquiphellandrene, alpha-curcumene and trans-beta-farnesene. The docking results showed the lowest binding energy values ​​for each compound sequentially for ACE-trans beta farnesene, ACE-alpha curcumene, ACE-zingiberene, ACE-farnesene, ACE-beta sesquiphellandrene are -5.14 kcal/mol, -5.61 kcal/mol , -6.20 kcal/mol, -5.66 kcal/mol, and -6.55 kcal/mol. Based on these results, the lowest bond energy among the 5 compounds was -6.55 kcal/mol at ACE-beta sesquiphellandrene docking, so the red ginger ethanol extract can be proposed and tested further as a clinical candidate for antihypertensive drugs.
Uji Sitotoksisitas Ekstrak Metanol Alga Cokelat (Phaeophyta) Pada Lini Sel Kanker Payudara MCF - 7 Isma Kurniatanty
Integrated Lab Journal Vol. 8 No. 2 (2020)
Publisher : UIN Sunan Kalijaga Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/ilj.2020.080209

Abstract

Marine algae (brown algae) have been considered as a source of bioactive compounds as they may be used as food, material for industry and herbal medicine. The objective of this study was to determine the cytotoxic activity of methanolic extracts of brown algae on breast cancer cell lines (MCF-7 cells) as anticancer candidates. Preperation of methanolic extract of brown algae have been done by using maseration method. The dry brown algae was extracted by using methanol, filtered, then dried. Cytotoxic activity test was conducted by using MTT assay on MCF-7 cells. The result showed that methanolic extract of Turbinaria ornata, T. deccurrens and Sargassum myriocystum had cytotoxic activity on MCF-7 cells with IC50 value of 221,88, 268,34 and 250,23 μg/ ml.
Kadar Gula Darah Dan Gambaran Histopatologi Pankreas Tikus Putih (Rattus norvegicus L.) Hiperglikemia Setelah Pemberian Ekstrak Etanol Jenggot Musa (Tillandsia usneoides L.) Isma Kurniatanty; Yuniati Wadhihah
Bioveritas Journal of Biology Vol. 1 No. 01 (2022)
Publisher : Departmet of Biology, Universitas Islam Negeri Sunan Kalijaga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/bioveritas.v1i01.4152

Abstract

Diabetes mellitus is a disease characterized by hyperglycemia due to the destruction of pancreatic cells as insulin-producing cells. Natural ingredients from plants are an alternative for diabetes treatment, one of which is beard musa (Tillandsia usneoides L.). Beard musa is a plant that has bioactive compounds in the form of flavonoids that have the potential to help control blood sugar levels. This study aims to determine the effect of beard musa ethanol extract on reducing blood sugar levels and histopathological description of the pancreas of white rats (Rattus norvegicus) induced by alloxan. The study was divided into five treatment groups, namely positive control, negative control, dose I (dose of 125 mg/kg BW), dose II (dose of 250 mg/kg BW), and dose III (dose of 500 mg/kg BW). The test animals used were white rats weighing 150-300 grams which were acclimatized for 7 days. After that, the test animals were induced with alloxan for 7 days before treatment to determine the hyperglycemic effect. The treatment in each group was carried out for 14 days in which negative control was given aquadest, positive control was given glibenclamide, and doses I, II and III were given beard musa extract with 4 times of blood collection, namely days 0, 7, 14, and 21. Then the phytochemical screening was carried out with the flavonoid test and the alkaloid test. On day 21, mice were sacrificed to make histological preparations. The results showed that the three doses of beard musa ethanol extract were able to reduce blood glucose levels in hyperglycemic rats, where a dose of 250 mg/kg BW was more capable of providing a hypoglycemic (antidiabetic) effect to normal blood sugar levels in hyperglycemic white rats with successive decreases during 14 days compared to other doses. While the ethanol extract of beard musa at all doses did not affect the structure of the pancreatic cells of hyperglycemic white rats.
Antihypertension Activity Test oOf Red Ginger (Zingiber officinale Var. Rubrum Roscoe) Ethanol Extract by In Silico Method Risti Zahroh; Isma Kurniatanty; Jumailatus Sholihah; Esti Wahyu Widowati
Journal of Food and Pharmaceutical Sciences Vol 9, No 3 (2021): J.Food.Pharm.Sci
Publisher : Institute for Halal Industry and System (IHIS) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.2694

Abstract

Hypertension or high blood pressure is a condition when there is an increase in blood pressure above the normal threshold (> 140/90 mmHg). The bioactive compounds in red ginger are dominated by the terpene group which has the ability to inhibit the action of Angiotensin Converting Enzyme (ACE-inhibitor). The interaction between ACE-inhibitory peptides can be predicted by the in silico method. The in silico method was used to predict the interaction and binding energy between bioactive compounds in red ginger ethanol extract (ligand) and ACE protein (receptor) which acts as an antihypertensive. The results of GC-MS obtained as many as 5 compounds (zingiberene, farnesene, ß -sesquiphellandrene, alpha-curcumene and trans-beta-farnesene. The docking results showed the lowest binding energy values ​​for each compound sequentially for ACE-trans beta farnesene, ACE-alpha curcumene, ACE-zingiberene, ACE-farnesene, ACE-beta sesquiphellandrene are -5.14 kcal/mol, -5.61 kcal/mol , -6.20 kcal/mol, -5.66 kcal/mol, and -6.55 kcal/mol. Based on these results, the lowest bond energy among the 5 compounds was -6.55 kcal/mol at ACE-beta sesquiphellandrene docking, so the red ginger ethanol extract can be proposed and tested further as a clinical candidate for antihypertensive drugs.
Co-Authors Esti Wahyu Widowati Jumailatus Sholihah Risti Zahroh Yuniati Wadhihah