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All Journal Jurnal Sain Veteriner Jurnal Veteriner STI Policy and Management Journal Jurnal Kebijakan Pembangunan
Hartiningsih Hartiningsih
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Calcium and Phosphor Retention in The Panhisterectomized Rats Fed High Calcium Hartiningsih Hartiningsih
Jurnal Sain Veteriner Vol 30, No 1 (2012): JUNI
Publisher : Fakultas Kedokteran Hewan Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (497.065 KB) | DOI: 10.22146/jsv.2464

Abstract

The objectives of the research was to study the effect of panhisterectomy on calcium (Ca) and phosphor (P) retention in the female Sprague Dawley rats that were fed teri which ratio of Ca:P is 3:1 for 12 weeks. Ten female of Sprague Dawley rats, 6 weeks of age were randomly divided into two groups (control and  anhisterectomized groups) of five each. At 8 weeks of age, the rats of panhisterectomized group were panhisterectomized. At 20 weeks of age, they were placed into individual metabolic cages for balance study. The remaining of feed was collected for calcium and phosphor analyses. Every morning, from days 4 to 8 of the balance study, urine andfecal samples were also collected at the same time. The research results showed that calcium and phosphor retentions were significantly reduced (P<0.05) in panhisterectomized group compared to that of the control group. Fecal calcium excretion was a significantly higher (P<0.05), whereas fecal and urinary phosphor excretions were significantly higher (P<0.05) in the panhisterectomized group compared to that of the control group. It is concluded that panhisterectomy leads to a reduction of the calcium and phosphor retention in the Sprague Dawley rats that were fed high calcium.Keywords : panhisterectomized, calcium, phosphor retention, individual metbolic cages, Sprague Dawleyrats
Kombinasi Calcitriol dan Ethynil Ethyl Estradiol Meningkatkan Ekskresi Kalsium Urin dan Risiko Urolitiasis pada Tikus Ovariektomi Hartiningsih Hartiningsih; Ayu Dewi Puspitasari; Nurdysa Diliana Putri; Nurul Arifah; Wari Pawestri; Devita Anggraeni
Jurnal Veteriner Vol 18 No 2 (2017)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (173.684 KB) | DOI: 10.19087/jveteriner.2017.18.2.239

Abstract

The high excretion of calcium (Ca) in the urine can trigger the formation of urolith. Estrogen and calcitriol decrease urinary Ca excretion. This study aims to examine the combination of calcitriol and ethinyl ethyl estradiol against Ca urinary excretion and urolithiasis risk of ovariectomized rats. Twentyfive female Wistar rats eight weeks old were divided into five groups: i) normal control (NK); ii) ovariectomized control (OVK); iii) ovariectomized + calcitriol (OVD); iv) ovariectomized + ethinyl ethyl estradiol (OVE); and v) ovariectomized + combination calcitriol and ethinyl ethyl estradiol (OVDE). Seven weeks post-ovariectomy, each rat was put in an individual metabolic cage for the study of Ca balance. At day 4 to 7 of the study, residual feed, urine, and feces were collected daily for Ca analysis. At day 8, the rats were euthanized, the left kidney were collected for histopathological examination. The results showed that combination of calcitriol and ethinyl ethyl estradiol in OVDE rats caused Ca intake and Ca intestinal absorption significantly higher, and urinary Ca excretion tended to be higher although not significantly different compared to OVK rats. Calcium excretion in OVK rat urine was higher compared to the NK rats. The kidney histopathological changes of OVK rats were not different from the NK rats. Histopathological examination of the OVDE group kidney showed protein deposition in the capsular of Bowman’s capsule and proximal tubules, atrophy of the proximal tubules, and necrosis, respectively. It is concluded that the combination of calcitriol with ethinyl ethyl estradiol in ovariectomized rats increased urinary Ca excretion and increased the risk of urolithiasis. ABSTRAK Tingginya ekskresi kalsium (Ca) dalam urin dapat menjadi pemicu terbentuknya urolit. Estrogen dan calcitriol menurunkan ekskresi Ca urin. Penelitian ini dilakukan bertujuan untuk mengkaji kombinasi calcitriol dan ethynil ethyl estradiol terhadap ekskresi Ca dalam urin dan risiko urolitiasis tikus ovariektomi. Sebanyak 25 tikus Wistar betina umur delapan minggu, dibagi menjadi lima kelompok (kontrol normal NK, kontrol ovariektomi OVK, ovariektomi + calcitriol OVD, ovariektomi + ethynil ethyl estradiol OVE, dan ovariektomi + kombinasi calcitriol dan ethynil ethyl estradiol OVDE). Tujuh minggu pascaovariektomi, setiap tikus dimasukan kandang metabolik individu untuk studi keseimbangan Ca. Pada hari ke-4 sampai 7 studi keseimbangan Ca, setiap hari sisa pakan, urin, dan feses dikumpulkan untuk analisis Ca. Pada hari ke-8 studi keseimbangan Ca, tikus dieutanasi, ginjal kiri diambil untuk pemeriksaan histopatologi. Hasil analisis menunjukkan bahwa kombinasi calcitriol dan ethynil ethyl estradiol pada tikus OVDE menyebabkan konsumsi Ca dan absorpsi Ca intestinal nyata lebih tinggi, dan ekskresi Ca dalam urin cenderung lebih tinggi meskipun tidak berbeda nyata dibanding tikus OVK. Ekskresi Ca dalam urin tikus OVK lebih tinggi dibanding tikus NK. Gambaran histopatologi ginjal OVK terlihat tidak berbeda dengan tikus NK. Histopatologi ginjal OVDE terlihat endapan protein dalam ruang kapsuler kapsula Bowman’s dan tubulus proksimalis, tubulus proksimalis atropi, dan nekrosis. Dari hasil penelitian disimpulkan bahwa kombinasi calcitriol dengan ethynil ethyl estradiol pada tikus ovariektomi meningkatkan ekskresi Ca urin dan meningkatkan risiko urolitiasis.
Dynamics of Bioplastics Development in Indonesia Qinan Maulana Binu Soesanto; Dian Prihadyanti; Hartiningsih Hartiningsih; Trina Fizzanty
STI Policy and Management Journal Vol 1, No 2 (2016): STI Policy and Management
Publisher : Center for Science and Technology Development Studies, Indonesian Institute of Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (846.027 KB) | DOI: 10.14203/STIPM.2016.48

Abstract

Increase in consumption of conventional plastics lead to environmental problems. Therefore, some efforts are needed to overcome it, one of them by using bioplastics. However, in Indonesia, companies engaged in bioplastics sector are still rarely found. Without the readiness of the bioplastics industry in Indonesia, development of bioplastics which ends to solve environmental problems cannot be realized. Through Socio-Technical Systems (STS) approach with Multi Level Perspective framework, this Papper analyze the dynamics of the transition of bioplastics in Indonesia. The results show the presence of pressure from landscape to underdeveloped niche, regime actors would give respond by modifying path development from its innovation activities. In other words, bioplastics in Indonesia has not yet experiencing a transition to replace conventional plastics. Precisely, technology in regime level experiencing change by developing additive plastic. However, there are several things that hinder further development of the niche, which include the high price of bioplastics and implementation of regulations related with incentives and disincentives and there is no coordination and shared vision between actor in niche level.  
Potensi Wisata Religi Dan Problematika Pengembangannya Hartiningsih Hartiningsih
Jurnal Kebijakan Pembangunan Vol 14 No 2 (2019): JURNAL KEBIJAKAN PEMBANGUNAN
Publisher : Badan Riset dan Inovasi Daerah Provinsi Kalimantan Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kabupaten Hulu Sungai Utara (HSU) memiliki sejumlah objek wisata diantaranya adalah Candi Agung. Candi Agung dianggap bukan saja sebagai objek wisata sejarah dan budaya melainkan juga sebagai objek wisata religi. Kendati candi tidak mengalami perkembangan yang cukup signifikan, namun wisatawan yang berkunjung ke candi cukup banyak mencapai ribuan pengujung perminggu. Melalui penelitian ini, penulis ingin mengetahui potensi Candi Agung dan problem yang dihadapi dalam pengembangannya. Jenis penelitian deskriptif dengan pendekatan kualitatif. Teknik pengumpulan data dilakukan melalui observasi, wawancara dan dokumentasi. Hasil penelitian menggambarkan, situs-situs yang terdapat di areal candi memiliki daya tarik sekaligus potensi wisatawan mengunjungi candi, disamping karena akses yang mudah dijangkau dan sarana serta prasarana yang mmadai. Prolematika pengembangan, hasil penelitian mngindikasikan, sektor pariwisata bukan sektor yang diprioritaskan. Lembaga tidak berdiri sendiri, SDM, anggaran yang kecil, sinergitas kerjasama dengan SKPD, dan CSR lainnya belum ada. Areal candi masih kental dikuasai oleh masyarakat setemat.
Co-Authors Ayu Dewi Puspitasari Devita Anggraeni Dian Prihadyanti Nurdysa Diliana Putri Nurul Arifah Qinan Maulana Binu Soesanto TATI NURHAYATI Trina Fizzanty Wari Pawestri