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UJI TOKSISITAS SUBKRONIS EKSTRAK ETANOL DAUN TUMBUHAN SALA (Cynometra ramiflora Linn.) DENGAN PARAMETER KIMIA URIN DAN HISTOPATOLOGI ORGAN GINJAL PADA TIKUS GALUR WISTAR Haryoto -; Andi Suhendi; Eka Prasnaparamita W; Tanti Azizah Sujono; Muhtadi -
PROSIDING SEMINAR NASIONAL & INTERNASIONAL 2015: Prosiding Bidang MIPA dan Kesehatan The 2nd University Research Colloquium
Publisher : Universitas Muhammadiyah Semarang

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Abstract

Tumbuhan Sala (Cynometra ramiflorra Linn.) merupakan salah satu tumbuhan mangrove, yang memiliki beberapa manfaat antara lain antioksidan, antihiperglikemia, dan antiinflamasi. Uji toksisitas subkronis digunakan untuk mengetahui toksisitas suatu senyawa yang dilakukan selama 90 hari. Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan ekstrak etanol daun Sala terhadap parameter kimia urin dan histopatologi ginjal. Penelitian ini merupakan penelitian eksperimental dengan rancangan Post Test Controlled Group Design, yaitu melihat perubahan yang terjadi pada tikus setelah diberi perlakuan. Sampel penelitian terdiri dari 20 ekor tikus putih jantan yang dibagi 4 kelompok dosis perlakuan. Kelompok pertama merupakan kelompok kontrol yang diberi CMC-Na (Sodium Carboxy Methyl Cellulose), kelompok kedua, ketiga, dan keempat diberi ekstrak etanol daun Sala dengan dosis 500, 1000, dan 1500 mg/kgBB. Parameter yang diamati yaitu kimia urin dan histopatologi ginjal. Parameter kimia urin dievaluasi menggunakan urin tampungan pagi hari pada hari ke-0, 45, dan 90 menggunakan reagen strip. Hasil parameter kimia urin tikus untuk kelompok kontrol dan perlakuan selama 90 hari memberikan pengaruh pada parameter protein, glukosa, keton, bilirubin, urobilinogen terhadap fungsi ginjal, namun tidak mempengaruhi pH dan nitrit. Hasil histopatologi menunjukkan terjadinya peradangan pada ginjal tikus yang diberi ekstrak etanol daun Sala dengan dosis 1000 dan 1500 mg/kgBB.Kata kunci: Cynometra ramiflora Linn., toksisitas subkronis, kimia urin
UJI TOKSISITAS AKUT DARI EKSTRAK KULIT BUAH RAMBUTAN (Nepheliumlappaceum L.) YANG BERPOTENSI SEBAGAI OBAT HERBAL ANTIDIABETES Muhtadi -; Haryoto -; Tanti Azizah Sujono; Andi Suhendi
PROSIDING SEMINAR NASIONAL & INTERNASIONAL 2015: Prosiding Bidang MIPA dan Kesehatan The 2nd University Research Colloquium
Publisher : Universitas Muhammadiyah Semarang

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The acutetoxicitytestinghave been conducted inthe male and female ratsSD strain oframbutan (Nepheliumlappaceum L.)fruitpeel extract. The testing had been doneby providingwitha doserankedasfollows: the firstdose; 0mg/kgBW, doseII; 400mg/kgBW, doseIII; 1,400mg/kgBW, IVdoses; 4,900mg/kgBW, and thedosage ofV; 17,150mg/ kgBW for 14days. Thenit had been observedclinical symptomsthat happened, changed in body weightperweekanddefect on vital organs, namely: the liver, kidneys, stomach, intestines, spleen, heartandlungs. Theresults ofthis study was concludedthat thehighest doseof up to17,150mg/kgBW ofthe extract, safety andproved to be not toxic to thefemaleandmaleratsSDstrain.Keywords : The acutetoxicitytesting; rambutanfruitpeel extract; thefemaleandmaleratsSDstrain.
INTRODUKSI TEKNOLOGI TEPAT GUNA UNTUK PERBAIKAN PROSES PRODUKSI DAN PENGEMBANGAN USAHA JAMU HERBAL DI CV. ARBA’IN JAYA MANDIRI SURAKARTA Muhtadi -; Andi Suhendi; Agus Triyono; Agus Ulinuha
PROSIDING SEMINAR NASIONAL & INTERNASIONAL 2015: Prosiding Bidang Teknik dan Rekayasa The 2nd University Research Colloquium
Publisher : Universitas Muhammadiyah Semarang

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Abstract

IPTEKDA LIPI XVIII activities in 2015 was intended to improve the quality and capacity of production in SMEs CV. Arba'in Jaya Mandiri Surakarta, through the introduction of some technology included medicinal herb powder mixer machines, mixer machines for honey, and semi-manual capsule filling. While in the second phase, will be introduced vacuum evaporator machine and application software for the development marketing online of herbal medicinal and honey products Arba'in. The results had been achieved in the first phase of IPTEKDA LIPI 2015, ie an increased in productivity and efficiency of production procesing as well as improving the quality of herbal medicine production. The mixing process of herbal ingredients were more efficient with the capacity of mixing up to 25 kg / process, from only 3-5 kg / process before. The process of mixing herbs-based honey, had showed a more homogeneous mixing and faster. Through the introduction and applications of technology production procesing, it was hoped will provide multifier effect for SMEs, employment, supplier partners and the communities.Keywords : SMEs CV. Arba'in Jaya Mandiri Surakarta, the introduction of efficient technology, production process improvement, business development of herbal medicine
Co-Authors Agus Triyono Agus Ulinuha Andi Suhendi Eka Prasnaparamita W Haryoto - Tanti Azizah Sujono