Garuda - Garba Rujukan Digital

T. Z. Jacoeb

Unknown Affiliation

Author-ID : 290843

Health Professions Medicine & Pharmacology Public Health

Published : 3 Documents Claim Missing Document

Claim Missing Document

Articles

Cytosolic estrogen and progesterone receptor content in the endometriotic tissues and endometrium in women with and without endometriosis Jacoeb, T. Z.; Nuruliza, C.; Chaniago, N.
Medical Journal of Indonesia Vol 14, No 3 (2005): July-September
Publisher : Faculty of Medicine Universitas Indonesia

In order to have a profile of cytosolic estrogen and progesterone receptors in either endometriotic tissue or endometrium in patients with and without endometriosis a cross-sectional study was performed involving 43 infertile women. They consisted of 31 (72.09%) endometriosis and 12 (27.91%) non-endometriosis cases; their average age was 32 Â± 4 years and 32 Â± 3 years respectively, with the average length of menstrual cycle 31 Â± 8 days and 29 Â± 1 days respectively. The endometriotic tissue was obtained by excision during operative laparoscopy procedure, while the endometrium was obtained by biopsy following hysteroscopy procedure. These procedures were conducted within the periovulatory period (on Day 13-18 of the cycle). The sex steroid receptor content in the cytosol was measured quantitatively using enzyme-immunoassay method, and calculated as sex steroid receptor/cytosol protein (fmol/ml cytosol). It was found that the average cytosolic estrogen receptor concentration in the respective tissues were 512.99 fmol/ml in the endometriotic ovary compared with 2369.17 in normal ovary and 632.18 fmol/ml in the endometriotic peritoneum compared with 9607.61 fmol/ml in normal peritoneum; while 99.28 fmol/ml and 608.33 fmol/ml in the endometrium of women with endometriosis and those without endometriosis respectively. The average cytosolic progesterone receptor concentration found in the respective tissues were 50.64 fmol/ml in the endometriotic ovary compared with 6469.42 fmol/ml in normal ovary and 1631.40 fmol/ml in endometriotic peritoneum compared with 12466.99 in normal peritoneum, while 21.26 fmol/ml and 599.61fmol/ml in the endometrium of women with endometriosis and those without endometriosis respectively. There is no significant difference in the receptor concentration between each tissue according to its topographic origin. However, this result may assume that the responsivity on hormonal treatment in endometriosis cases will depend on the cytosolic sex steroid receptor content in the sick tissues, and the peritoneal lesions will possibly give better response than those in other sites. A further clinical trial is necessary. (Med J Indones 2005; 14: 133-41)Keywords: Estrogen, progesteron, receptor, cytosol, endometriosis, endometrium, infertile

Management of adenomyosis in infertile women: comparison between laparotomic resection and administration of aromatase inhibitor (Experience in 55 cases) Rajuddin, Rajuddin; Jacoeb, T. Z.
Medical Journal of Indonesia Vol 15, No 1 (2006): January-March
Publisher : Faculty of Medicine Universitas Indonesia

The objective of this study was to observe the results of adenomyosis mangement with resection and administration of aromatase inhibitor. Cases of ademyosis in infertile women were collected for three years (January 1999 to December 2001) and the diagnoses were confirmed using transvaginal USG. Cases were grouped into two groups, i.e. group 1 (undergoing laparotomic resection) and group 2 (receiving treatment with aromatase inhibitor of anastrozole). Both groups were evaluated for changes in clinical symptoms, rate of successful pregnancy, and postoperative recurrency rate. During three years as many as 1619 infertility cases were managed, and among which 66 (4.07%) cases of adenomyosis were diagnosed with transvaginal USG. As many as 55 cases were analyzed, i.e., 32 cases underwent resection and 23 cases received aromatase inhibitor. Of 32 cases of surgical resection, the histopathological results showed 30 (93.75%) cases of adenomyosis and 2 (6.25%) cases of uterus myoma. In the group undergoing resection three cases (9.4%) were successfully pregnant, i.e., two cases had live birth, one case ended up with 6-week abortion. Moreover, 25 (78.1%) cases were not pregnant and 4 (12.5%) cases had recurrency, while 24 (75.35%) cases experienced disappearance of symptoms yet not pregnant. On the other hand, of 23 cases in the group receiving aromatase inhibitor 2 (8.6%) cases were able to be pregnant, one case had live birth and another case ended up with abortion, while 14 (59.1%) cases had disappearance of symptoms yet not pregnant. During three months of treatment with aromatase inhibitor, a reduction in the lesion size between 7.31 mm3 and 25.90 mm3 were observed with CI 95% (p < 0.001). In conclusion, treatment with aromatase inihibitor did not heal lesions, but only reduced the size of adenomyosis lesions. On the other hand, resection could heal lesions, yet recurrency of disease may occur (12.5%) after one postoperative year. (Med J Indones 2006; 15:18-23) Keywords: adenomyosis, resection, aromatase inhibitor, anastrozole

Penanganan Adenomiosis dengan Reseksi Laparotomik pada Perempuan Infertil (Pengalaman pada 32 kasus) RAJUDDIN, RAJUDDIN; JACOEB, T. Z.
Indonesian Journal of Obstetrics and Gynecology Volume. 32, No. 1, January 2008
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (34.463 KB)

Tujuan: Untuk melihat hasil tatalaksana pengobatan adenomiosis dengan reseksi. Rancangan/rumusan data: Kajian retrospektif deskriptif. Tempat: Klinik Fertilitas dan Menoandropause SamMarie Jakarta. Bahan dan cara kerja: Dikumpulkan kasus adenomiosis pada perempuan infertil selama tiga tahun (Januari 1999 sampai Desember 2001) yang diagnosis ditegakkan dengan USG transvaginal. Kasus dilakukan reseksi secara laparotomi dan dilakukan pemeriksaan Patologi anatomi sebagai diagnosis pasti adenomiosis uteri. Dan pascareseksi dinilai perubahan gejala klinis, angka keberhasilan hamil dan laju kekambuhan. Hasil: Selama 3 tahun ditangani 1619 kasus infertilitas dan terdapat 66 (4,07%) kasus adenomiosis yang didiagnosis dengan USG trasvaginal. Sebanyak 32 kasus dilakukan tindakan operasi reseksi dengan hasil histopatologi menunjukkan 30 (93,75%) kasus adenomiosis dan 2 (6,25%) kasus mioma uteri. Yang berhasil hamil adalah 3 (9,4%) kasus yaitu dua kasus melahirkan hidup, satu kasus berakhir dengan abortus 6 minggu. Dan 25 (78,1%) kasus tidak hamil dan 4 (12,5%) kasus terjadi kekambuhan penyakit. Hilang gejala tapi tidak hamil 24 (75,35%) kasus. Kesimpulan: Pengobatan adenomiosis dengan reseksi dapat menyembuhkan lesi dan dapat terjadi kehamilan. Kekambuhan penyakit dapat terjadi setelah satu tahun pascareseksi. [Maj Obstet Ginekol Indones 2008; 32-1: 22-5] Kata kunci: adenomiosis, reseksi, infertil

Title

Found 3 Documents
Search

Abstract

Abstract

Abstract

Title Search

Found 3 Documents Search

Abstract

Abstract

Abstract

Title

Found 3 Documents
Search