Article Per Year (5 Year)
p-Index From 2021 - 2026
0
P-Index
This Author published in this journals
All Journal Jurnal Kimia (Journal of Chemistry)
K. D. Adnyani
Program Studi Farmasi Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Udayana
Chemistry

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
OPTIMASI METODE EKSTRAKSI KUERSETIN DARI DAUN KELOR (Moringa oleifera L.) N. P. L. Laksmiani; I W. A. Widiantara; K. D. Adnyani; A. B. S. Pawarrangan
Jurnal Kimia (Journal of Chemistry) Vol.14 No.1 Januari 2020
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (596.65 KB) | DOI: 10.24843/JCHEM.2020.v14.i01.p04

Abstract

Moringa plants is very abundant in Indonesia. Moringa leaves are a source of polyphenol compounds, namely flavonoids. One of the main flavonoids found in Moringa leaves is quercetin. To be able to increase the concentration of quercetin from moringa plants, extraction is necessary. This study aims to determine the most optimal extraction method in extracting quercetin from Moringa leaves. Optimization of quersein extraction methods from Moringa leaves was carried out using maceration, soxhletation, and reflux methods. The solvent used was methanol acidified with 1,2 N HCl. Determination of the concentration of quercetin in the extract used a validated TLC-densitometry method. The highest rendement obtained from the maceration extraction method was 24.08 % w/w. Extraction by reflux and sochletation methods yielded rendement of 23.44 % w/w and 10.12 % w/w respectively. Qualitative analysis of quercetin in the extract was carried out by comparing its Rf value with the standard quercetin which is 0,4. The quercetin level of the extract from maceration extraction was the highest, which was 24.45 % w/w. Extraction using the soxhletation method obtained quercetin as much as 20.95 % w/w. Keywords: quercetin, Moringa oleifera leaves, extraction method, optimization
AKTIVITAS DARI KUERSETIN SEBAGAI AGEN PENCERAH KULIT SECARA IN SILICO K. D. Adnyani; L. W. E. Lestari; H. Prabowo; P. A. I. A. Siaka; N. P. L. Laksmiani
Jurnal Kimia (Journal of Chemistry) Vol.13 No.2 Juli 2019
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (329.92 KB) | DOI: 10.24843/JCHEM.2019.v13.i02.p14

Abstract

Increasing melanogenesis process causes excessive melanin synthesis resulting in darkening of the skin color. The melanogenesis process requires mealnogenesis enzymes, one of which is tyrosinase-related protein 1. One of the flavonoid compounds that has the potential as a skin lightening agent is quercetin. The antioxidant activity of quercetin plays a very important role in antimelanogenesis. This study aims to determine the affinity and molecular mechanism of quercetin on the target protein tyrosinase-related protein 1 using in silico molecular docking method. Molecular docking is carried out through stages including optimization of the structure of quercetin compounds, preparation of the target protein tyrosinase-related protein 1, validation of the molecular docking method, and docking of quercetin on the tyrosinase-related protein 1. Docking of quercetin with tyrosinase-related protein 1 produces binding energy values of -7.81 kcal/mol, while docking of native ligand with tyrosinase-related protein 1 produces binding energy values of -5.39 kcal/mol. Quercetin has a strong affinity for tyrosinase-related protein 1 which is indicated by the binding energy from the docking results. Quercetin has activity as a skin whitening agent with in silico test with molecular mechanisms through inhibition of the activity of tyrosinase-related protein 1 enzyme. Keywords: skin whitening agent, in silico, quercetin, tyrosinase-related protein 1
Co-Authors A. B. S. Pawarrangan H. Prabowo I W. A. Widiantara L. W. E. Lestari Ni Putu Linda Laksmiani P. A. I. A. Siaka