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A. A. Tia Santika Dewi
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Chemistry

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AKTIVITAS ANTIINFLAMASI EKSTRAK ETER KULIT BATANG TENGGULUN (Protium javanicum Burm) TERHADAP EDEMA PADA TIKUS WISTAR YANG DIINDUKSI DENGAN KARAGENAN A. A. Tia Santika Dewi; Ni Made Puspawati; Putu Suarya
Jurnal Kimia (Journal of Chemistry) Vol. 9, no. 1 Januari 2015
Publisher : Program Studi Kimia, FMIPA, Universitas Udayana (Program of Study in Chemistry, Faculty of Mathematics and Natural Sciences, Udayana University), Bali, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (99.839 KB) | DOI: 10.24843/JCHEM.2015.v09.i01.p03

Abstract

Stem bark of Tenggulun (Protium javanicum, Burm) has been used traditionally by Balinese people as anti-inflammatory agents. This research aimed to analyze phytochemical contents and to evaluate anti-inflammatory activity of stem bark ether extract of Tenggulun. Phytochemical study was done qualitatively using phytochemical reagents. Anti-inflammatory activity was evaluated on edema rats induced by carrageenan with given extract at doses of 125, 250, and 500 mg/kg b.w. Diclophenac sodium was used as the positive control. Phytochemical study revealed that the stem bark ether extracts consisted of alkaloids, steroids, terpenoids, and phenolic compounds.  Anti-inflammatory activity test  results showed at a dose of 125 mg/kg b.w, the extract only inhibit inflammation by 34.54%, while a dose of 250 mg/kg b.w gave inhibition of inflammation by 94.34%, and a dose of 500 mg/kg b.w can inhibit inflammation by 96.11% during 360 minutes observation. Probit analysis gave ED50 value of 103.252 mg/kg B.W.
Co-Authors Ni Made Puspawati Putu Suarya