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Ida Ayu Adhistania Pidada
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Daun Kelor Memperbaiki Histopatologi Hati Tikus Putih yang Mengalami Diabetes Melitus Ida Ayu Adhistania Pidada; Ni Luh Eka Setiasih; Ida Bagus Oka Winaya
Buletin Veteriner Udayana Vol. 10 No. 1 Pebruari 2018
Publisher : The Faculty of Veterinary Medicine, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (842.591 KB) | DOI: 10.24843/bulvet.2018.v10.i01.p08

Abstract

This study aims was to investigate the improvement of hepar histopathology experimental diabetic rats given moringa oleifera leaves ethanolic extract. 24 male white rats induced by a single dose STZ of 45mg/kg intraperitoneal to cause diabetes mellitus. After declared with diabetes disease, rats were divided into 6 groups consist of 1 a control group and a treatment group of 5 who were given ethanol extracts of leaves of the kelor, with a dose of 100, 200, 300, 400, and 500mg/kg, for 5 weeks. Rats then sacrificed and the hepar were taken for the histopathology preparations with Hematoxylin-Eosin staining (HE). Each preparation histopathology examined under a microscope in five visual fields at 400x magnification. The processed data is then analyzed statistically by test Non parametric Kruskal Wallis followed by Mann-Whitney test, when there is a significant difference (P<0.05). The results showed that the hepar has improved a result of the damage diabetes mellitus after given Moringa oleifera leaves ethanolic extract with a dose of 400 mg/kg.
Co-Authors Ida Bagus Oka Winaya Ni Luh Eka Setiasih