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All Journal E-Jurnal Medika Udayana Eureka Herba Indonesia
Karina Chandra
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Health Professions Medicine & Pharmacology

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PREVALENSI DAN KARAKTERISTIK PITYRIASIS VERSICOLOR DI RSUP SANGLAH DENPASAR PERIODE JANUARI 2017 – DESEMBER 2017 Karina Chandra; NLP. Ratih Vibriyanti Karna; A.A.G.P. Wiraguna
E-Jurnal Medika Udayana Vol 8 No 12 (2019): Vol 8 No 12 (2019): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (349.169 KB)

Abstract

Pityriasis versicolor (PV) merupakan infeksi jamur yang hampir selalu ditemukan di seluruh dunia dan banyak sekali dijumpai di daerah tropis dengan kelembaban tinggi, Indonesia satu diantaranya. Penelitian dilakukan dengan tujuan mengetahui berapa prevalensi serta bagaimana karakteristik Pityriasis versicolor di RSUP Sanglah Denpasar periode dari Januari tahun 2017 – Desember tahun 2017. Penelitian ini adalah cross sectional deskriptif menggunakan metode total sampling. Sumber data adalah 36 rekam medis pasien Pityriasis versicolor periode Januari 2017 – Desember 2017. Hasil penelitian menunjukkan bahwa total jumlah pasien poli kulit dan kelamin di RSUP Sanglah Denpasar periode Januari 2017 – Desember 2017 adalah 3185 orang, dimana 36 orang (1,13%) merupakan pasien Pityriasis versicolor. Dari 36 orang pasien Pityriasis versicolor ditemukan umumnya pada kelompok umur 11-20 tahun sejumlah 14 orang (38,8%), terbanyak pada jenis kelamin laki-laki sejumlah 22 orang (61,1%) dan paling banyak dijumpai pada pasien dengan profesi sebagai pelajar sejumlah 11 orang (30,6%). Lesi hipopigmentasi paling banyak ditemukan sejumlah 29 orang (80,6%) dengan lokasi lesi pada daerah badan sejumlah 17 orang (47,2%). Sebagian besar pasien tidak ada riwayat keluarga dengan Pityriasis versicolor sejumlah 33 orang (91,7%). Pasien sebagian besar memiliki riwayat pengolesan minyak sejumlah 25 orang (69,4%), memiliki riwayat penggunaan obat imunosupresan (steroid) sejumlah 24 orang (66,7%) dan sebagian besar tidak ada riwayat diabetes melitus sejumlah 30 orang (83,3%). Kata kunci: Prevalensi Penderita, Karakteristik Penderita, Pityriasis versicolor
Modulation of the Cognition-Sleep Nexus in Subjective Cognitive Decline: A 12-Week, Randomized, Double-Blind, Placebo-Controlled Trial of a Standardized Cordyceps militaris Extract Vita Amanda; Daphne Marshall; Zahra Amir; Husin Sastranagara; Danniel Hilman Maulana; Karina Chandra; Fachrudin Sani
Eureka Herba Indonesia Vol. 6 No. 2 (2025): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v6i2.130

Abstract

Subjective cognitive decline (SCD) and sleep disturbance form a vicious cycle, accelerating neurodegeneration. Cordyceps militaris (CM), a traditional medicinal fungus rich in nucleosides, possesses potent neuroprotective and adenosinergic (sleep-promoting) properties. We investigated the efficacy of a standardized CM extract on this cognition-sleep nexus in adults with SCD. This 12-week, single-center, randomized, double-blind, placebo-controlled, parallel-group trial was conducted in Palembang, Indonesia. We randomized 120 adults (aged 45-65) with SCD to receive 300 mg/day of a standardized CM mycelial extract (3% cordycepin) or a matching placebo. The primary outcome was the change from baseline in the Montreal Cognitive Assessment-Indonesian (MoCA-INA) score. Key secondary outcomes (Bonferroni-corrected) were the Pittsburgh Sleep Quality Index (PSQI), Rey Auditory Verbal Learning Test (RAVLT) Delayed Recall, and polysomnography (PSG)-derived Sleep Efficiency (SE). Analyses were performed on the Intention-to-Treat (ITT) population (N=120) using a Linear Mixed-Effects Model (LMM). The LMM analysis revealed a significant group-by-time interaction for the primary outcome, MoCA-INA (Adjusted Mean Difference [AMD]: +1.95 [95% CI: 1.10, 2.80], p < 0.001). The CM group also showed significant improvements in all three key secondary outcomes: PSQI (AMD: -2.90 [95% CI: -3.81, -1.99], p < 0.001), RAVLT Delayed Recall (AMD: +2.15 [95% CI: 1.30, 3.00], p < 0.001), and Sleep Efficiency (AMD: +5.8% [95% CI: 3.1, 8.5], p < 0.001). After FDR correction, significant benefits were also seen for processing speed, %REM sleep, and serum BDNF and hs-CRP. The intervention was well-tolerated. In conclusion, twelve weeks of supplementation with a standardized C. militaris extract significantly improved cognitive function, episodic memory, and both subjective and objective sleep in adults with SCD. These benefits were associated with enhanced neuroplasticity and reduced systemic inflammation, supporting its potential as a multi-target, disease-modifying intervention for this at-risk population.
Co-Authors A.A.G.P. Wiraguna Danniel Hilman Maulana Daphne Marshall Fachrudin Sani Husin Sastranagara Ni Luh Putu Ratih Vibriyanti Karna Vita Amanda Zahra Amir