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All Journal BALI MEDICAL JOURNAL (BMJ) Medicina INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES E-Jurnal Medika Udayana Jurnal Ilmiah Bimbingan Konseling Undiksha Indonesian Journal of Cardiology Jurnal Ilmiah Pendidikan dan Pembelajaran ISM (Intisari Sains Medis) : Jurnal Kedokteran JOURNAL LA MEDIHEALTICO
I Wayan Wita
Faculty Of Medicine Udayana University, Denpasar, Bali-Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : BALI MEDICAL JOURNAL (BMJ)

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Gaharu Leaf Water Extract Reduce MDA and 8-OHdG Levels and Increase Activities SOD and Catalase in Wistar Rats Provided Maximum Physical Activity Parwata, I Made Oka Adi; Manuaba, Ida Bagus Putra; Sutirtayasa, I Wayan Putu; Wita, I Wayan
BALI MEDICAL JOURNAL Vol 5 No 3 (2016)
Publisher : BALI MEDICAL JOURNAL

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Abstract

Background: Oxidative stress occurs due to an imbalance of the number of free radicals by the number of endogenous antioxidant produced by the body i.e. Superoxide Dismutase (SOD), Gluthathione Peroxidase (GPx), and Catalase. The imbalance between the number of free radicals and antioxida nts can be overcome with the end ogenous antioxidant intake that exogenous oxidative stress can be reduced. O ne of exogenous antioxidants is natural Gaharu leaf water extract. Objective: This research focus on the effect of Gaharu leaf water extract in reducing MDA and 8- OHdG and increase the activity of SOD and Catalase. Methods: This study was an experimental with post only controls group design. Experiment was divided into 5 groups of w istar rats, each consisting of 5 animals, i.e. negative control group without extract [K (-)], treatment 1 treated 50 mg/ kg BW/day of the extract (T1), treatment 2 treated 10 0 mg/ kg BW/day of the extract (T2), treatment 3 treated 200 mg/ kg BW/day of the extract (T3), and positive control group [K (+)] treated with vitamin Cat a dose 50 mg/ kg BW/day. All groups treated for 10 weeks. Every day, before treatment, each group was given a maximum swimming activity for 1.5 hours for 10 weeks. ELISA was used to measure MDA, 8-OHdG, SOD , and C atalase activities . Result: The research results showed that treatment of extract of leaves of Gaharu with an higher dose from 50 mg/kg BW up to 200 mg/ kg BW significantly decline (p
Co-Authors A.A.G. Sudewa Anak Agung Ayu Dwi Adelia Yasmin Anak Agung Ayu Mirah Adi Anwar Santosa Cahya Ningrum, Ni Komang Sri Adelia Dewa Bagus Sanjaya Dwijo Anargha Sindhughosa Franky Simarmata I Gde Raka Widiana I Gede Margunayasa I Gusti Agung Dewi Sarihati I Ketut Suastika I Made Bakta I Made Candiasa I Made Oka Adi Parwata I Made Putra Swi Antara I NYOMAN MANTIK ASTAWA I Putu Gede Budiana, I Putu Gede I Wayan Putu Sutirta Yasa Ida Bagus Aditya Nugraha Ida Bagus Putra Manuaba Kamardi, Stanly Luh Nyoman Ananda Mahayati M.Pd. Dra. Made Sulastri . Made Diska Radisti Diputra Ni Ketut Suarni Pangestu, Ni Luh Diah Wahyuning Prana Jagannatha, Gusti Ngurah Prof. Dr. I Ketut Dharsana,M.Pd . R. A.T. Kuswardhani Sri Wahjuni Suastika, Luh Oliva Saraswati Surya Pradnyana, I Wayan Agus Suryaningsih, Ni Putu Elsinthia Swi Antara, I Made Putra Wiryawan, I Nyoman Yasmin, A.A. Ayu Dwi Adelia Yudha Dewangga, Made Satria