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All Journal BALI MEDICAL JOURNAL (BMJ) Medicina INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES E-Jurnal Medika Udayana Jurnal Ilmiah Bimbingan Konseling Undiksha Indonesian Journal of Cardiology Jurnal Ilmiah Pendidikan dan Pembelajaran ISM (Intisari Sains Medis) : Jurnal Kedokteran JOURNAL LA MEDIHEALTICO
I Wayan Wita
Faculty Of Medicine Udayana University, Denpasar, Bali-Indonesia
Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Journal : INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES

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ORAL INTAKE OF SARDINELLA LONGICEPS OIL THE DECREASE OF TNF-? AND IL-6 LEVELS IN ATHEROSCLEROTIC WISTAR RAT Wahjuni, S.; Sudewa, A.A.G.; Wita, I Wayan; Astawa, I.N. Mantik
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 5, No. 2 Mei 2011
Publisher : Udayana University

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Abstract

Lifestyle changes to consumption of variegated instant food may be associated several heath hazards, such as obesity, dyslipidemia, and atheroschlerosis. This study was conducted to investigate the effects of orally administered Sardinella longiceps oil as an anti inflammatory agent on the serum levels of TNF-? and IL-6 considered as biomarkers for atherosclerosis.The study design is an true experimental with randomized pretest and posttest control group design, using 50 Wistar rat equaly divided into 5 groups, i.e. placebo control group 0% and 4 treatment groups each treated daily with 10%, 15 %, 20 % and 25 % fish oil respectively for 6 weeks. Before the treatment was started, all rats were orally fed daily with a high cholesterol diet for 13 weeks to induce atherosclerosis. Our study showed that the intake of 20% fish oil had resulted in the significantly greatest decrease of 45,63 % in the TNF-? serum levels,from 28.62 ± 1.25 to 15.56 ± 7.20 ?g/mL and similar significant decrease 15,42% in of IL-6 serum levels from 134.64 ± 1.98 to 113.87 ± 4.30 ?g/mL. The overall results of our study seemed to imply than in the Wistar rats, oral intake of Sardfinella longiceps oils signifacantly decreased serum levels of TNF-? and IL-6 probably through their anti-inflamatory effects. Futher research to determin the magnitude of effects sardinella longiceps oils on the serum levels TNF-? and IL-6 human.
RISKS FOR PERIPHERAL ARTERIAL DISEASE IN THE ELDERLY WITH TYPE 2 DIABETES MELLITUS : Their Correlation with High Sensitivity C-reactive Protein and Ankle-Brachial Index Ayu Tuty Kuswardhani, Raden; Wita, Wayan; Bakta, Made; Santosa, Anwar
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 3, No. 2 Juli 2009
Publisher : Udayana University

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The Indonesian elderly population has been projected to increase up to about four-fold inthree decades (1990-2020). As a consequence of this population trend, the increased prevalence ofdegenerative diseases would be inevitable; this would include the prevalence of peripheral arterialdisease.This study aims to identify the correlation of diverse risk factors, either traditional or nontraditional,with the ankle-brachial index scores, and the correlation of novel non-traditional riskfactor, e.i. high sensitive C-reactive protein with the prevalence of perioheral arterial disease in theelderly, age 60-80 years old, with type 2 diabetes mellitus.Among the 146 elderly patients with type 2 diabetes mellitus, and based on measurement ofthe ABI score, approximately 30.9% of them had PAD. Some traditional and non-traditional riskfactors having a significant correlation with the ankle-brachial index score, were age (r = -0.396, p <0.001 for right ABI; r = -0.509, p < 0.001 for left ABI), supine systolic blood pressure (r= -0.268, p =0.012 for right ABI; r = -0.267, p = 0.013 for left ABI), 2-hour post-prandial blood glucose (r= -0.252, p = 0.018 for right ABI), and hsCRP (r = -0.280, p = 0.011 for right ABI; r = -0.402, p <0.001 for left ABI); whereas other risk factors like obesity based on waist circumference and BMI,non-supine systolic blood pressure, fasting blood glucose, HbA1C, duration of diabetes, plasma lipidsdid not show statistically significant different odd ratios. After linear regression test for risk factorshaving significant correlations with ABI, age and hsCRP were found to influence the ABI scores.Based on a case-control study, risk factors which, to some extent, had statistically significant valuesas risk factors, include older age (? 70 years old; OR = 7.737 [CI = 2.515-23.805]; p < 0.001),relatively high supine diastolic blood pressure (? 90 mmHg; OR = 6.882 [CI = 0.789-60.060]; p =0.048), and high concentration of hsCRP (> 3 mg/L; OR = 4.420 [CI = 1.287-15.181]; p = 0.013).Among these statistically significant risk factors, after logistic regression test analysis, only the age ofthe patient appeared to have significant influence on the prevalence of PAD.In conclusion, this study demonstrates a negative correlation between hsCRP and ABI score;and high levels of hsCRP appeared to be a risk factor for PAD. The age of the patient, however,appeared to be the strongest risk factor for PAD.
Co-Authors A.A.G. Sudewa Anak Agung Ayu Dwi Adelia Yasmin Anak Agung Ayu Mirah Adi Anwar Santosa Cahya Ningrum, Ni Komang Sri Adelia Dewa Bagus Sanjaya Dwijo Anargha Sindhughosa Franky Simarmata I Gde Raka Widiana I Gede Margunayasa I Gusti Agung Dewi Sarihati I Ketut Suastika I Made Bakta I Made Candiasa I Made Oka Adi Parwata I Made Putra Swi Antara I NYOMAN MANTIK ASTAWA I Putu Gede Budiana, I Putu Gede I Wayan Putu Sutirta Yasa Ida Bagus Aditya Nugraha Ida Bagus Putra Manuaba Kamardi, Stanly Luh Nyoman Ananda Mahayati M.Pd. Dra. Made Sulastri . Made Diska Radisti Diputra Ni Ketut Suarni Pangestu, Ni Luh Diah Wahyuning Prana Jagannatha, Gusti Ngurah Prof. Dr. I Ketut Dharsana,M.Pd . R. A.T. Kuswardhani Sri Wahjuni Suastika, Luh Oliva Saraswati Surya Pradnyana, I Wayan Agus Suryaningsih, Ni Putu Elsinthia Swi Antara, I Made Putra Wiryawan, I Nyoman Yasmin, A.A. Ayu Dwi Adelia Yudha Dewangga, Made Satria