Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal E-Jurnal Medika Udayana Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research
Made Agus Dwianthara Sueta
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
HUBUNGAN ANTARA KADAR CARCINOEMBRYONIC ANTIGEN (CEA) DAN STADIUM KANKER KOLOREKTAL DI RSUP SANGLAH TAHUN 2016-2017 I Gusti Ngurah Putu Neo Yunatsi Barata; Made Agus Dwianthara Sueta; Made Suka Adnyana
E-Jurnal Medika Udayana Vol 7 No 12 (2018): Vol 7 No 12 (2018): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (164.031 KB)

Abstract

Kanker kolorektal menduduki urutan keganasan ke-empat terbanyak di dunia dan penyebab kematian kedua terbanyak (terlepas dari gender) di dunia. Umumnya perkembangan kanker kolorektal merupakan interaksi antara faktor lingkungan dan faktor genetik. Mayoritas penderita kanker kolorektal tidak bergejala, sehingga penting dilakukan skrining. Skrining yang biasa dikerjakan adalah pengecekan kadar CEA. Penelitian ini bertujuan untuk mengetahui hubungan antara kadar CEA dan stadium kanker kolorektal di RSUP Sanglah Denpasar tahun 2016-2017. Penelitian ini merupakan penelitian cross-sectional analitik dengan sampel yang digunakan adalah pasien kanker kolorektal di RSUP Sanglah Denpasar tahun 2016-2017 yang memenuhi kriteria inklusi dan eksklusi berjumlah 60 orang rekam medis yang berisi kadar CEA dan stadium kanker kolorektal. Dari hasil analisis korelasi didapat hubungan antara kadar CEA dan stadium kanker kolorektal sebesar 0,459. Analisis kemaknaan dengan uji spearman menunjukkan bahwa nilai p = 0,00. Dimana dari hasil analasis tersebut menunjukkan adanya hubungan positif antara kadar CEA dan stadium kanker kolorektal yang menyimpulkan bahwa semakin tinggi kadar CEA semakin berat stadium kanker kolorektal. Kata Kunci: Kadar CEA, Kanker Kolorektal, Stadium
Severity Matters: The Differential Impact of Mild versus Severe Portal Hypertension on Post-Hepatectomy Liver Failure — A Systematic Review and Meta-Analysis Aflis; Ketut Wahyu Ananda Putra; Made Agus Dwianthara Sueta
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1575

Abstract

Background: Post-hepatectomy liver failure (PHLF) remains the principal cause of mortality following liver resection for malignancies, particularly in the context of hepatocellular carcinoma (HCC) and cirrhosis. While portal hypertension (PH) has traditionally been viewed as a monolithic contraindication to surgery, emerging evidence suggests that the risk it confers is heterogeneous. This study investigates the hypothesis that the risk of PHLF is strictly severity-dependent. Methods: A systematic review and meta-analysis were conducted on observational studies involving patients undergoing hepatectomy for liver malignancies. Search strategies targeted studies stratifying outcomes by PH severity (mild vs. severe). Primary outcomes were the incidence of PHLF defined by ISGLS criteria. Data were synthesized using random-effects models to calculate pooled odds ratios (OR). Results: Ten studies comprising 4,978 patients were included. The overall presence of PH significantly increased PHLF risk (Pooled OR 3.12; 95% CI: 2.15–4.53; p<0.001). However, stratification revealed a profound divergence: Severe PH (defined as HVPG ≥10 mmHg or clinically significant varices) was associated with a drastic risk escalation (OR 5.86; 95% CI: 2.19–15.65), whereas Mild PH showed a significantly lower risk profile (OR 2.45; 95% CI: 1.10–5.40). Sensitivity analyses confirmed that non-invasive surrogates for PH performed comparably to invasive hemodynamic monitoring in predicting failure. Conclusion: The risk of PHLF is not binary but graded. Severe portal hypertension represents a prohibitive risk state characterized by hemodynamic intolerance to parenchymal reduction. Conversely, mild portal hypertension constitutes a distinct, manageable clinical entity where liver resection remains safe under optimized conditions. Surgical candidacy should be determined by severity grading rather than the mere presence of portal hypertension.
Severity Matters: The Differential Impact of Mild versus Severe Portal Hypertension on Post-Hepatectomy Liver Failure — A Systematic Review and Meta-Analysis Aflis; Ketut Wahyu Ananda Putra; Made Agus Dwianthara Sueta
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 5 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i5.1575

Abstract

Background: Post-hepatectomy liver failure (PHLF) remains the principal cause of mortality following liver resection for malignancies, particularly in the context of hepatocellular carcinoma (HCC) and cirrhosis. While portal hypertension (PH) has traditionally been viewed as a monolithic contraindication to surgery, emerging evidence suggests that the risk it confers is heterogeneous. This study investigates the hypothesis that the risk of PHLF is strictly severity-dependent. Methods: A systematic review and meta-analysis were conducted on observational studies involving patients undergoing hepatectomy for liver malignancies. Search strategies targeted studies stratifying outcomes by PH severity (mild vs. severe). Primary outcomes were the incidence of PHLF defined by ISGLS criteria. Data were synthesized using random-effects models to calculate pooled odds ratios (OR). Results: Ten studies comprising 4,978 patients were included. The overall presence of PH significantly increased PHLF risk (Pooled OR 3.12; 95% CI: 2.15–4.53; p<0.001). However, stratification revealed a profound divergence: Severe PH (defined as HVPG ≥10 mmHg or clinically significant varices) was associated with a drastic risk escalation (OR 5.86; 95% CI: 2.19–15.65), whereas Mild PH showed a significantly lower risk profile (OR 2.45; 95% CI: 1.10–5.40). Sensitivity analyses confirmed that non-invasive surrogates for PH performed comparably to invasive hemodynamic monitoring in predicting failure. Conclusion: The risk of PHLF is not binary but graded. Severe portal hypertension represents a prohibitive risk state characterized by hemodynamic intolerance to parenchymal reduction. Conversely, mild portal hypertension constitutes a distinct, manageable clinical entity where liver resection remains safe under optimized conditions. Surgical candidacy should be determined by severity grading rather than the mere presence of portal hypertension.
Co-Authors Aflis I Gusti Ngurah Putu Neo Yunatsi Barata Ketut Wahyu Ananda Putra Made Suka Adnyana