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All Journal E-Jurnal Medika Udayana Indonesian Journal of Rheumatology
Made Dyah Vismita Indramila Duarsa
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Health Professions Medicine & Pharmacology

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HIPERTENSI SEBAGAI FAKTOR RISIKO NYERI NEUROPATI DIABETIK PADA PASIEN DIABETES MELLITUS TIPE II DI RSUP SANGLAH DENPASAR Made Dyah Vismita Indramila Duarsa; I Komang Arimbawa; Ida Ayu Sri Indrayani
E-Jurnal Medika Udayana Vol 8 No 10 (2019): Vol 8 No 10 (2019): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (297.111 KB)

Abstract

Neuropati diabetik (ND) adalah komplikasi mikrovaskular yang paling sering terjadi pada pasien Diabetes Mellitus (DM) tipe 2. ND sebagian besar akan menimbulkan komplikasi lanjutan yaitu nyeri neuropati diabetik (NND) yang secara signifikan menurunkan kualitas hidup pasien DM. Hipertensi disebutkan sebagai salah satu faktor yang signifikan mempercepat terjadinya NND pada pasien DM. Tujuan penelitian ini adalah menentukan faktor risiko sebelum penatalaksanaan sehingga dapat meningkatkan outcome pada pasien. Penelitian ini menggunakan metode kasus kontrol dengan teknik pengambilan sampel consecutive sampling. Analisis data dilakukan dalam dua tahapan: (1) statistik deskriptif terkait karakteristik dasar subjek penelitian; (2) statistik analitik untuk menghitung Odds Ratio (OR) antara kelompok kasus dan kontrol. Dari 56 sampel yang diperiksa didapatkan hasil dari 2 tahapan analisis: (1) Statistik deskriptif terkait dengan hipertensi pada kelompok kasus, kontrol adalah 21 orang (75,00%),11 orang (39,30%); (2) Statistik analitik antara hipertensi dan kejadian NND OR=4,636 IK 95%, p =0,007 (p <0,05) artinya hipertensi memiliki hubungan bermakna dengan angka kejadian NND. Faktor perancu pada penelitian ini ; obesitas, dislipidemia, dan DM tidak terkontrol menunjukkan hasil p tidak bermakna terhadap kejadian NND (p>0,05). Hipertensi adalah faktor risiko independen terhadap angka kejadian NND. Kata Kunci : Nyeri Neuropati Diabetik, Diabetes Mellitus, Hipertensi
Risk Factor Associated with Carotid Intima-Media Thickness inPatients with Systemic Lupus Erythematosus Made Dyah Vismita Indramila Duarsa
Indonesian Journal of Rheumatology Vol. 17 No. 1 (2025): IJR VOL 17 No 1
Publisher : Indonesian Rheumatology Associantion

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v17i1.15

Abstract

Background: Cardiovascular complications, including atherosclerosis, arethe highest causes of mortality in systemic lupus erythematosus (SLE)patients. The carotid artery intima-media thickness (cIMT) can effectivelyindicate the condition of atherosclerosis in patients. This study wasconducted to determine the associated risk factors for cIMT in patientswith SLE. Methods: This research was conducted as a cross-sectionalstudy at Prof. I.G.N.G. Ngoerah Hospital, Denpasar. From January 2023to June 2023, all SLE patients aged 18-55 for men and 18-65 for women,without infections, cancer, asthma, stage 5 chronic kidney disease, stroke,coronary heart disease, peripheral artery disease, or smoking history, wereincluded. Measurement of cIMT was performed using Dopplerultrasonography. Statistical analysis was conducted using descriptivestatistics and Fisher exact test to assess the association between variables.Results: 52 patients (51 women and 1 man) met the inclusion criteria wereincluded. The mean age was 33.67 ± 10.51 years, the duration of SLE bythe time of diagnose was 50.37 ± 40.39 months, and the disease activityscored by MEX SLEDAI was 2.58 ± 3.24. Moreover, the bivariate analysisshowed a significant association between hypertension and cIMT in SLEpatients (p = 0.001) with an Odd Ratio (OR) of 28.77. The age at diagnosiswas also found to be significantly associated independently with cIMT (p =0.003, OR = 14.93). This is associated with dysregulation of lectin -likeoxidized-LDL (ox-LDL) receptor-1 (LOX-1), leading to an increased risk ofatherosclerotic plaque formation. Conclusion: There is a notableassociation between the occurrence of hypertension and age at diagnosisto the elevated cIMT in SLE patients. 
Co-Authors I Komang Arimbawa Ida Ayu Sri Indrayani