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All Journal Journal of Sustainable Transformation Jurnal Penelitian Hasil Hutan
Umul Karimah
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PENAMBATAN MOLEKUL SIANIDIN Ipomoea batatas L. SEBAGAI INHIBITOR HUMAN EPIDERMAL RECEPTOR 2 (HER-2) PADA KANKER PAYUDARA Ayubbi, Muhammad Reza Pahlevy Al; Melati, Rika; Karimah, Umul
Journal of Sustainable Transformation Vol. 1 No. 2 (2023)
Publisher : Universitas Nahdlatul Ulama Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59310/jst.v1i2.14

Abstract

HER-2 (Human Epidermal Receptor 2) is a receptor on the cell surface that affects cell proliferation, this receptor support controls healthy cell growth,divide and repair cells when they are damaged. When HER-2 had overexpressed will not controlled cancer cell division. Overexpressed HER-2 could inhibited with cyanidine compound flavonoid derivatives from Ipomoea batatas L. (purple sweet potato). This study aim to measured potential of Ipomoea batatas L. cyanidin compounds in inhibited overexpressed HER-2 using computational chemistry methods specifically is molecular docking. Stages of molecular docking receptor HER-2 is ligand set up with drew structure cyanidine with Marvin Sketch then optimized by Autodock Tools and Discovery Studio, lapatinib as a comparison ligand downloaded on PubChem website. HER-2 (3PP0) prepared with downloaded on Protein Data Bank website then optimized by Autodock Tools. Molecular Docking validated with docked protein target with native ligand by PyMOL to secured RMSD (root mean square deviation). Protein Targeted HER-2 docked with test ligand cyanidine, lapatinib, and native ligand by Autodock VINA, analysed energy bond and amino acid residue interactions by LigPlot+. Cyanidine had potency inhibitor of receptor HER-2 overexpressed from docked is had bound energy -7.1 ccal/mol up to -8.6 ccal/mol wich is also had amino acid residue interactions Met 801 equal to native ligand
PENGUKURAN KADAR FLAVONOID TOTAL EKSTRAK ETANOL & FRAKSI ETIL ASETAT DAUN JERUK PURUT (Citrus hystrix DC) DENGAN METODE SPEKTROFOTOMETRI UV-VIS Rizky Saputra, Dewa; Melati, Rika; Karimah, Umul
Journal of Sustainable Transformation Vol. 2 No. 01 (2023)
Publisher : Universitas Nahdlatul Ulama Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59310/jst.v2i01.26

Abstract

This study measured the total flavonoid content of 70% ethanol extract and the ethyl acetate fraction of kaffir lime leaves (Citrus hystrix DC). The purpose of this study was to measure the total flavonoid content of the 70% ethanol extract and the ethyl acetate fraction of kaffir lime leaves (Citrus hystrix DC). Extraction of the chemical content of kaffir lime leaves (Citrus hystrix DC) was carried out by maceration and remaceration extraction processes using ethanol and to measure the metabolite compounds. flavonoids in total and separate other metabolites by a fractionation process,). Measurement of total flavonoid content of ethanol extract and ethyl acetate fraction by UV-Vis spectrophotometry. The results showed that the total flavonoid content of kaffir lime leaves (Citrus DChystrix DC) from the ethanol extract contained a total flavonoid content of 14,380 mgQE/g and the ethyl acetate fraction contained a total flavonoid content of 44,287 mgQE/g.
PHYSICAL AND CHEMICAL PROPERTIES OF LOCAL HONEY FROM EAST KALIMANTAN Umul Karimah; Rika Melati; Ayu Anita Sari Ratna Saputri
Jurnal Penelitian Hasil Hutan Vol. 38 No. 2 (2020): Jurnal Penelitian Hasil Hutan
Publisher : BRIN Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20886/jphh.2020.38.2.119-128

Abstract

Most of the local honey production in East Kalimantan is managed traditionally, thus honeyquality, particularly its physical and chemical properties, are unknown. However, the honey analysisSURYLGHVDFRPSUHKHQVLYHFRPSRVLWLRQSUR¿OHDQGSRWHQWLDOO\JLYHVKLQWVWRLPSURYHWKHTXDOLW\RIlocal honey from East Kalimantan. This research aimed to analyse the properties of two local honeyfrom East Kalimantan. The methods used in this study were gravimetric, volumetric, spectroscopy,spectrophotometry, and chromatography. Honey A was produced by Apis cerana whereas Apis dorsataproduced honey B. The color intensities were 560±5.66 and 947.5±27.58 mAu for honey A and B,respectively. Honey A and B a had moisture content of 22.7 and 25.8% w/w, respectively. Otherproximate analysis parameters were also reported. Fructose and glucose content for honey A were30.65±2.35% w/w and 30.08±0.58% w/w, while honey B gave different pattern with fructose at28.06±1.04 and higher glucose instead at 32.74±1.13% w/w. Reducing sugar and total sugar forboth samples were higher than 60% w/w while sucrose in honey A and B were 2.8 and 1.4% w/wrespectively, thus indicating no adulteration. Vitamin C content measurement showed negligibleresult with total phenolic content of honey A was lower than honey B. Honey B had higher Na,Ca, Fe and Zn than those of honey A. This study reported thorough chemical composition of localKRQH\V IURP (DVW .DOLPDQWDQ LQ ZKLFK VRPH FRXOG KDYH VLJQL¿FDQW QXWULWLRQDO YDOXH +RZHYHUquality improvement particularly on moisture and reducing sugar content is necessary to meetIndonesian National Standard 8664:2018.
Co-Authors Ayu Anita Sari Ratna Saputri Ayubbi, Muhammad Reza Pahlevy Al Rika Melati Rizky Saputra, Dewa