Article Per Year (5 Year)
p-Index From 2020 - 2025
0
P-Index
This Author published in this journals
All Journal JURNAL BIOMEDIK
Ronny Karundeng
Fakultas Kedokteran Universitas Sam Ratulangi Manado
Biochemistry, Genetics & Molecular Biology Health Professions

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
PERAN MELANOKORTIN PADA MELANOSIT Mamoto, Natalia; Kalangi, Sonny; Karundeng, Ronny
Jurnal Biomedik : JBM Vol 1, No 1 (2009): JURNAL BIOMEDIK : JBM
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.1.1.2009.805

Abstract

Abstract: Melanocyte, an important component of the skin pigmentation system, has the ability to produce and distribute melanin. This skin pigmentation system consists of melanocytes, melanosomes, tyrosinase enzymes, and the melanogenesis process. The biochemical process of the skin pigmentation (melanogenesis) is very complex, and produces eumelanin and pheomelanin pigments, both are tyrosine derivates. Melanocortins are found in the forms of a-MSH, b-MSH, g-MSH, and ACTH. Melanocortins play some important roles in certain physiologic responses of human beings, such as: the skin pigmentation, adrenal function, sexual function, analgesia, temperature controle, cardiovascular controle, inflammatory process, energy homeostasis, endocrine secretion, diet-intake controle, and autonomic function.  In general, the responses are proceeded by binding of melanocortins to their receptors. Key words: melanocyte, melanin, melanocortin, melanogenesis.     Abstrak: Melanosit merupakan komponen penting dalam sistem pigmentasi kulit melalui kemampuannya dalam menghasilkan dan mendistribusikan melanin. Sistem pigmentasi kulit melibatkan melanosit, melanosom, melanin, enzim tirosinase dan proses melanogenesis. Proses biokimia pigmentasi kulit (melanogenesis) bersifat sangat kompleks. Proses melanogenesis ini menghasilkan pigmen eumelanin dan feomelanin. Baik eumelanin maupun feomelanin keduanya adalah derivat tirosin melalui beberapa tahapan. Melanokortin terdiri atas a-MSH, b-MSH, g-MSH dan ACTH. Melanokortin terlibat dalam pengaturan respon fisiologi manusia, yaitu pigmentasi kulit, fungsi adrenal, fungsi seksual, analgesia, kontrol temperatur, kontrol kardiovaskuler, inflamasi, homeostasis energi, sekresi endokrin, mengontrol asupan makanan, dan fungsi otonom. Secara umum respon ini diawali dengan pengikatan melanokortin dengan reseptornya. Kata kunci: melanosit, melanin, melanokortin, melanogenesis.
JARINGAN LEMAK PUTIH DAN JARINGAN LEMAK COKLAT Aspek histofisiologi Karundeng, Ronny; Wangko, Sunny; Kalangi, Sonny J. R.
Jurnal Biomedik : JBM Vol 6, No 3 (2014): JURNAL BIOMEDIK : JBM Suplemen
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.6.3.2014.6328

Abstract

Abstract: There are two types of adipose tissues, white adipose tissue and brown adipose tissue. White adipose tissue is distributed in subcutaneous tissues meanwhile brown adipose tissue is located in certain parts of the body, neck and interscapulaar regions, in fetus and infants. Cells of adipose tissue are named adipocytes. The adipocyte of white adipose tissue contains one lipid locus (unilocular), meanwhile the adipocyte of brown adipose tissue contains many small lipid inclusions (multilocular). In adults, all adipose tissues show similar histological features-unilocular. Albeit, in certain conditions, adipocytes of brown adipose tissues can reverse to their former features, multilocular. Each type of these adipose tissue has its own characteristic in hitological and functional aspects.Keywords: white adipose tissue, brown adipose tissue, histological characteristics, functionAbstrak: Terdapat dua jenis jaringan lemak yaitu jaringan lemak putih dan jaringan lemak coklat. Jaringan lemak putih tersebar pada jaringan subkutan sedangkan jaringan lemak coklat banyak terdapat di daerah leher dan interskapular pada fetus dan bayi. Sel jaringan lemak disebut adiposit. Pada usia dewasa, semua jaringan lemak terlihat sebagai lemak unilokuler tetapi pada kondisi tertentu jaringan lemak coklat dapat kembali ke struktur semula, yaitu multilokular. Kedua jenis jaringan lemak memiliki kekhususan sendiri baik dari aspek histologik maupun fungsional.Kata kunci: jaringan lemak putih, jaringan lemak coklat, gambaran histologik, fungsi
KOMPONEN SEL JARINGAN IKAT Wangko, Sunny; Karundeng, Ronny
JURNAL BIOMEDIK : JBM Vol 6, No 3 (2014): JURNAL BIOMEDIK : JBM Suplemen
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/jbm.6.3.2014.6327

Abstract

Abstract: Connective tissue is distributed in all parts of the body and its main function is to connect cells and tissues. Most of the embryonic connective tissues are derived from embryonal messenchymal tissues. There are a variety of connective tissues which are compatible with their functions and locations. The general difference of all connective tissues is the arrangement and composition of intercellular matrix. Connective tissues are composed of two major components: cells and intercellular matrices. Connective tissue cells, fixed cells or wandering cells, have their special functions which support each other to maintain the optimal histophysiology of the connective tissue.Keywords: connective tissues, cells, histophysiologyAbstrak: Jaringan ikat tersebar luas di seluruh bagian tubuh dengan fungsi utama untuk menghubungkan berbagai komponen sel atau jaringan. Hampir seluruh jaringan ikat embriologik berasal dari jaringan mesensimal embrional. Terdapat berbagai jenis jaringan ikat yang sesuai dengan fungsi dan lokasinya. Perbedaan utama dari berjenis-jenis jaringan ikat tersebut berdasarkan susunan dan komposisi matriks intersel. Jaringan ikat terdiri dari dua komponen dasar utama yaitu sel dan matriks intersel. Sel-sel jaringan ikat baik yang tetap maupun yang bebas mempunyai fungsi khusus masing-masing yang saling melengkapi untuk mempertahankan keutuhan histofisiologi jaringan ikat.Kata kunci: jaringan ikat, sel, histofisiologi
Co-Authors Natalia Mamoto Sonny J. R. Kalangi Sonny Kalangi Sunny Wangko