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All Journal Acta Interna : The Journal of Internal Medicine PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia)
Lutfan Budi Purnomo
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Health Professions Materials Science & Nanotechnology Medicine & Pharmacology

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The Difference Plasma Levels of Endotelin-1 in Type 2 Diabetes Mellitus Women with and without Hypertension Enita Rahmawati Kurniatmaja; Hemi Sinorita; Lutfan Budi Purnomo
Acta Interna The Journal of Internal Medicine Vol 5, No 1 (2015): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (208.249 KB) | DOI: 10.22146/acta interna.22356

Abstract

Background. Diabetes and hypertension are related to each other and have a strong pre-disposition on the incidence of atherosclerosis. The incidence of hypertension 2 times greater in patients with DM than non DM. Endothelial dysfunction underlies these events. Endothelial markers, endothelin-1 is known to affect blood pressure.Aim. The aim of this study is to determine the difference plasma levels of endothelin-1 in type 2 diabetes mellitus in women with and without hypertension.Methods. The cross sectional design was conducted on women with type 2 diabetes mellitus with and without hypertension at metabolic and endocrinology clinic, Dr. Sardjito General Hospital Yogyakarta from July 2010 until the sample met the criterias. Subjects were divided into two groups, type 2 DM woman with hypertension groups and without hypertension. ELISA sandwich’s method was used to measure plasma levels of endothelin-1. Characteristics of the study are presented in the form of mean Kurniaatmaja et al.Results. In this research, the plasma levels of endothelin-1 in in type 2 diabetes mellitus in women with hypertension (n=32) and without hypertension (n=32) respectively 19.17±7.53 ng/ml and 13.75±6.19 ng/dl, and this difference was stastistically signifi cant with p= 0.003 CI 95% -8.87 to -1.97.Conclusion. Plasma levels of endothelin-1 in type 2 diabetes woman with hypertension higher than without hypertension. 
PATIENT CHARACTERISTICS FACTORS ON THE QUALITY OF LIFE TYPE 2 DIABETES MELLITUS PATIENTS WITH INSULIN-BASED THERAPY Lolita Lolita; Trimurti Andayani; Lutfan Budi Purnomo
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 10 No. 02 Desember 2013
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pji.v10i2.802

Abstract

ABSTRACT Type 2 Diabetes mellitus is a chronic disease that can not be cured completely, will affect Health Related Quality Of Life (HRQOL). The purpose of this study was to determine the QOL of type 2 DM patients based on patient’s characteristic factors (age, gender, educational status) at Endocrinology Clinic Dr. Sardjito Hospital Yogyakarta. This study is a cross sectional study with descriptive method. Data are taken concurrently by interview and from medical records of patients who visited the Endocrinology Clinic Dr. Sardjito Hospital between July 2012 until March 2013. The inclusion criteria of patients include patients who visit during the study, no constraint in the language and not having a nervous breakdown, and willing to participate the study. The quality of life was measured by Diabetes Quality of Life Clinical Trial Quessionnaire (DQLCTQ). There are several statistical analysis used in this study. Mann Whitney for QOL analysis based on gender, educational status. Kruskall Wallis for QOL analysis based on patient’s age. The results of 137 patients known that gender (p value= 0,000) and education status (p value = 0,000) was significantly influence the average value of quality of life. Whereas, the patient’s age (p value = 0,530) was not significantly affect the average value of quality of life. Keywords: patients characteristics factors, quality of life, type 2 diabetes mellitus
Co-Authors Enita Rahmawati Kurniatmaja Hemi Sinorita Lolita Lolita Trimurti Andayani