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All Journal Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Majalah Kedokteran Gigi Indonesia Journal of General Procedural Dermatology and Venereology Indonesia
Flandiana Yogianti
Department Of Dermatology And Venereology, Faculty Of Medicine, Universitas Gadjah Mada/ Dr. Sardjito General Hospital, Yogyakarta, Indonesia
Dentistry Immunology & microbiology Medicine & Pharmacology Neuroscience

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Effect of collagen-chitosan hydrogel formula combined with platelet-rich plasma (A study of ph, viscocity, and swelling test) Tutut Prabantari Anindyajati; Sri Pramestri Lastianny; Flandiana Yogianti; Kwartarini Murdiastuti
Majalah Kedokteran Gigi Indonesia Vol 6, No 3 (2020): December
Publisher : Faculty of Dentistry, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/majkedgiind.44391

Abstract

Platelet-rich plasma (PRP) contains growth factors that speed up a healing process. The liquid form of PRP is difficult to be applied, so it needs material as a carrier of collagen. Collagen can be used as carrier materials and capable to activate growth factors and increase the concentration of the PRP to become a gel. Collagen often losses its shape and size due to degradation when exposed to body fluids. In the selection of materials, collagen can synthesize with chitosan. Collagen-chitosan hydrogel has potential as scaffold. Many formulations for proper hydrogel applied in the oral cavity need to pay more attention to several conditions, such as a neutral pH, high viscosity and ideal swelling. The aims of this study was to examine the influence of various formulations of collagenchitosan hydrogel PRPagainst pH, viscosity, and swelling. The study samples consisted of 25 collagen-chitosanhydrogel formulations. The samples were divided into five groups: 100/0; 75/25; 50/50; 25/75; 0/100. The first stage of the test was pH, viscosity and swelling measurement of the collagen-chitosan hydrogel to determine which ones matched the criteria. Collagen-chitosan hydrogel formulations were added with PRP with a ratio of 1:1. The second stage was to measure the pH, viscosity, and swelling measurement to see the results of the physical parameters of the hydrogel after mixed with PRP. The observation data were analyzed by t-test for pH and viscosity, while twoway ANOVA and post hoc LSD for swelling test. The results showed that collagen-chitosan hydrogel formulations of 25/75 and 0/100 met the criteria of pH, viscosity, and swelling. The pH of both groups showed no significant difference (p>0.05), but the viscosity and swelling variables showed significant difference (p<0.05). To conclude, collagen-chitosan hydrogel formulations mixed with PRP had no effect on pH, but had an effect on viscosity and swelling test. The collagen-chitosan hydrogel formulations mixed with PRP which matched the criteria were 25/75 and 0/100.
Transplantation of melanocyte stem cells in vitiliginous skin Yohanes Widodo Wirohadidjojo; Flandiana Yogianti
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 47, No 4 (2015)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1453.378 KB) | DOI: 10.19106/JMedSci004704201503

Abstract

Depigmentation in vitiligo occurs as a result of progressive loss of functioning epidermal melanocytes, and currently various modalities have been developed to re-functioning these cells. However, in area with poor melanocytes reservoir, such as old-persistent lesions or lesions on bony prominence, the modalities are hardly to achieve repigmentation. Since spontaneous repigmentation of vitiliginous skins begin mostly in follicular areas, reactivation of melanocyte precursors along the outer root sheath of hair follicle is expected to have better on this pigmentation. Melanocyte precursor came from melanocyte stem cells that originally located on bulge area of hair follicles. The latest surgical intervention in vitiligo is transplantation of melanocyte stem cells. Clinical experiments indicated that the transplantation can be performed either by transplantation of extracted follicular units or single cell suspension harvested from this area. By single cell suspension treatment, a 50 cm2 of vitiliginous skin can be handled by 15 autologous hair follicular units. These procedures are easy and can be performed by any dermatologist especially who has been trained in dermatologic surgery as well as in cellular based therapies.
Extensive superficial dermatomycosis caused by Cladophialophora sp., a deep mycosis pathogen: A case report Limantara, Nikko Vanda; Siswati, Agnes Sri; Yogianti, Flandiana
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 9, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Superficial dermatomycosis, predominantly caused by dermatophytes, affects approximately 20–25% of the global population. However, non-dermatophytic fungi, such as Cladophialophora species (sp.), can also cause similar cutaneous infections. Although less common, these organisms are particularly concerning in immunocompromised individuals. Case Illustration: A 66-year-old immunocompromised male presented with widespread pruritic and erythematous patches, initially misdiagnosed as tinea corporis. Despite receiving standard antifungal therapy, his condition persisted. Further investigation through fungal culture identified Cladophialophora sp., which was resistant to common antifungal agents such as fluconazole, itraconazole, and ketoconazole. However, the fungus was sensitive to terbinafine, which has been successfully used to treat extensive superficial dermatomycosis. Discussion: This case highlights the ability of non-dermatophytic fungi, especially Cladophialophora sp., to cause extensive superficial dermatomycosis, especially in immunocompromised patients. The patient’s compromised immune system likely contributed to the extensive nature of the lesions. In this case, antifungal resistance may have been exacerbated by prior unsupervised self-medication and environmental exposure. Conclusion: We report an immunocompromised patient with inadequate prior antifungal treatment who developed extensive superficial dermatomycosis caused by Cladophialophora sp., a deep mycosis pathogen resistant to multiple azoles, highlighting the role of host immunity and inappropriate unsupervised therapy in disease severity and antifungal resistance.
Co-Authors Agnes Sri Siswati Kwartarini Murdiastuti Limantara, Nikko Vanda Sri Pramestri Lastianny, Sri Pramestri Tutut Prabantari Anindyajati Yohanes Widodo Wirohadidjojo