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All Journal International Journal of Public Health Science (IJPHS) Journal of the Medical Sciences (Berkala Ilmu Kedokteran) INDONESIAN JOURNAL OF PHARMACY Journal of Community Empowerment for Health
Hakim, Mohamad Saifudin
Department Of Microbiology, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada
Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

 1 
Current understanding of the origin, molecular biology and continuing evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Mohamad Saifudin Hakim; Luthvia Annisa; Endah Supriyati; Edwin W. Daniwijaya; Rakhmat A. Wibowo; Eggi Arguni; Titik Nuryastuti
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 52, No 3 (2020): Special Issue: COVID-19
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (740.09 KB) | DOI: 10.19106/JMedSciSI005203202005

Abstract

Recent outbreaks of human coronaviruses, officially named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have put health authorities worldwide on a high alert. Firstly emerged in the city of Wuhan, China, SARS-CoV-2 infection is rapidly escalating into a global pandemic. It is first thought as the result of a zoonotic transmission event, similar to the previous epidemic of coronaviruses. However, a continuously increasing number of confirmed cases indicates that the virus gains capacity of efficient human-to-human transmission. Soon after the pandemic is arising, many efforts are focused on identifying the origin of SARS-CoV-2 infection in the human population. Current evidence suggests that the virus is probably derived from bat or pangolin coronaviruses as the natural host. Whether intermediate host(s) exist in the transmission cascade from bat or pangolin to humans is, to a great extent, elusive. This information is essential as the basis for infection prevention and control measures. In this review, we discuss our recent understanding of SARS-CoV-2 biology, highlighting its origin and molecular evolution.
Early hydroxychloroquine and azithromycin as combined therapy for COVID-19: a case series Siswanto Siswanto; Oktaviarum S. Utama; Agit S. Adisetiadi; Maria E. Pranasakti; Mohamad Saifudin Hakim
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 52, No 3 (2020): Special Issue: COVID-19
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (335.738 KB) | DOI: 10.19106/JMedSciSI005203202016

Abstract

Coronavirus disease 2019 (COVID-19) is a worldwide outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The World Health Organization (WHO) has declared it as a public health emergency of international concern (PHEIC) and eventually a pandemic. Many clinical trials have been conducted to investigate potential and effective therapies for COVID-19. Here we reported the outcome of three COVID-19 cases treated early with the combination of hydroxychloroquine and azithromycin. Early treatments of suspected or confirmed positive COVID-19 cases with this combination therapy is to avoid disease progressions into a more severe and irreversible state. In these cases, clinical, radiological, and laboratory features were followed up. No complications were observed. The COVID-19 patients treated with this early combination therapy showed good clinical and virological responses.
Co-Authors Agit S. Adisetiadi Edwin W. Daniwijaya Eggi Arguni Fitra Duhita Iryna Dzyublyk Luthvia Annisa Maria E. Pranasakti Maryia Leleka Mumtihana Muchlis Mumtihana Muchlis Oktaviarum S. Utama Rakhmat Ari Wibowo Rita Dian Pratiwi Rita Dian Pratiwi Serhii Soloviov Siswanto Siswanto Supriyati Titik Nuryastuti Viktor Trokhymchuk Yati Soenarto