Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal Indonesian Journal of Cancer Chemoprevention Berita Kedokteran Masyarakat
Ari Probandari
Department of Public Health, Faculty of Medicine, Universitas Sebelas Maret
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Nursing Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Molecular Therapeutic Potency of Metformin by Targeting p53-Related Molecules in Mutant p53 Colon Cancer Cell Line Dyah R. Budiani; Melani R. Mahanani; Yohanes C. Wibowo; Ari Probandari; Diding H. Prasetyo; Ambar Mudigdo
Indonesian Journal of Cancer Chemoprevention Vol 7, No 1 (2016)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev7iss1pp17-24

Abstract

Colon cancer is a malignancy in gastrointestinal tract. It causes high mortality rate in global cancer population. However, chemotherapy as its first option therapy is still controversial due to its effectiveness and its adverse effects. Finding supportive and alternative drugs to cure cancer is one of focus in cancer research. A drug which also has anticancer effects is metformin. Metformin is a biguanide antidiabetic which show its potential anticancer benefit in metabolic-related cancers including colon cancer. To investigate anticancer potency of metformin in targeting p53-related molecules. Metformin treatment were divided into 4 groups by 0, 5, 10 and 20 mM concentrations and incubated in 37o C and 5 % CO2 condition for 48 hours. Immunohistochemistry were conducted to asses level of expression of Bax, p21, cyclin D1 and E2F1, respectively. Level of expression were measured by H-SCORE using percentage and intensity calculation. Comparisons of H-SCORE between groups were performed by ANOVA for parametrical data and Kruskal-Wallis for non-parametrical data. Growth inhibition were observed after metformin treatment. Metformin increases Bax expression significantly at all concentrations. p21 expression was also increased after metformin treatment but is not statistically significant. Subsequently, metformin decreases cyclin D1 expression at 10 and 20 mM concentration thus decreased E2F1 expression at 5 and 10 mM concentration. These data suggest that metformin may have potential therapeutic effects in mutant p53 colon cancer cell line by targeting p53-related molecules.Keywords: Colon cancer; p53; Biguanide; Metformin; p53-mutant cell line
Covid-19 risk factors and health protocol compliance among mall employees and officers in Yogyakarta Yunita Kemala Dewi; Ari Probandari
Berita Kedokteran Masyarakat (BKM) Vol 37, No 1 (2021)
Publisher : Fakultas Kedokteran Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (220.213 KB) | DOI: 10.22146/bkm.59065

Abstract

Purpose: This study aimed to analyze risk factors, compliance with health protocols, and the COVID-19 screening test among mall employees at Yogyakarta city, Indonesia.Methods: We analyzed secondary data from a cross-sectional study in Yogyakarta City from May-August 2020. The population was all employees at all malls in Yogyakarta City who participated in the screening rapid test zero survey conducted by the Yogyakarta City Government. Results: Bivariate analysis showed a significant relationship between ensuring proper mask install (OR = 6.33, p = 0.023, 95% CI = 1.03-38.81), applying a minimum distance of > 1 meter when outside home (OR = 27.34, p = 0.001, 95% CI = 3.01-248.32) and applying a minimum distance of > 1 meter when at work (OR = 22.25, p = 0.003, 95% CI = 2,45-201.65) with the reactive COVID-19 results. Multivariate analysis showed the most dominant variable associated with the reactive rapid test results is not keeping a minimum distance of > 1 meter when outside the house with a value of (OR=11.91, p=0.047, 95% CI = 1.03-137.37). Conclusion: The risk factor for Covid-19 for employees and mall staff is physical distancing > 1 meter when outside the house.  The city administration should keep working with mall managers to tighten health protocols in malls and other public areas to prevent Covid-19 transmission.
Co-Authors Ambar Mudigdo Diding H. Prasetyo Dyah R. Budiani Melani R. Mahanani Yohanes C. Wibowo Yunita Kemala Dewi