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Purwanto Purwanto
Fakultas Kedokteran Gigi Universitas Jember
Health Professions Library & Information Science

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Daya Hambat Ekstrak Minyak Atsiri Kulit Buah Jeruk Siam (Citrus nobilis L.) terhadap Pertumbuhan Candida albicans Oksalani Cahaya Rana; Ayu Mashartini Prihanti; Purwanto Purwanto
Pustaka Kesehatan Vol 9 No 3 (2021): Volume 9 No.3, 2021
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v9i3.17425

Abstract

The high prevalence of oral candidiasis needs special attention. Candida albicans (C. albicans) play a critical role in the progression of deeper oral candidiasis. An effective and safe strategy to control C. albicans activity was needed. The essential oil from siam orange peel has been shown to have antifungal properties. This study aimed to determine the optimal concentration of the essential oils of siam orange peel to inhibit the growth of C. albicans. This is experimental laboratory research with a posttest-only control group design. The water stream was used to get essential oil extract from siam orange peel and made in several concentrations 25%, 50%, 75%, and 100%. The disk diffusion method was applied to determine the inhibition of essential oil extract of siam orange peel to the C. albicans. Nystatin and DMSO 10% plus tween 80 0,5% were used as positive and negative control groups. The results found that the essential oil extract of siam orange peel concentration of 50% and above showed an inhibitory effect on the growth of C. albicans with the most optimal is 75%. The essential oil extract of Siam Orange Peel would be useful as a therapeutic agent to control oral candidiasis.
Daya Hambat Ekstrak Kulit Semangka (Citrullus lanatus) Terhadap Pertumbuhan Candida albicans Nindya Nur Maghfiroh; Ayu Mashartini Prihanti; Purwanto Purwanto
Pustaka Kesehatan Vol 9 No 1 (2021): Volume 9 No.1, 2021
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v9i1.10825

Abstract

Candida albicans is normal flora found in the oral mucosa in healthy individuals but has opportunistic pathogenic properties. The change in the oral cavity's environmental conditions can cause C. albicans to turn into a pathogen and cause oral candidiasis. Antifungal drugs that are common used for the treatment of oral candidiasis are topical nystatin preparations. Nystatin is an antifungal drug from the polyene group produced by Streptomyces noursei, which is thought to be very effective in treating diseases caused by C. albicans with a success rate 79.6 - 87.5%. The previous study showed that watermelon peel extract contains active compounds of alkaloids, flavonoids, tannins, and saponins. The active compound is known to have antifungal activity. The study aimed to determine the ability of watermelon peel extract to inhibit the growth of C. albicans. The type of research conducted is experimental laboratories using the post-test only control group design. The observations in this study about the inhibitory power of watermelon rind extract (Citrullus lanatus) on the growth of C. albicans showed that there were inhibitory zones of watermelon skin extract on the growth of C. albicans.
Daya Antibakteri Infusa Kulit Manggis (Garcinia mangostana L) terhadap Streptococcus mutans (Antibacterial of Mangosteen peel infuse (Garcinia mangostana L ) Against Streptococcus mutans) Muhamad Martin Widayat; Purwanto Purwanto; Amandia Dewi Permana Shita
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

One of the main causes of dental caries is Streptococcus mutans. Some sourcesmentioned in the mangosteen peel contains flavonoids, saponins and tannins whichhave antibacterial activity. The purpose of this research was to determine theantibacterial activity of mangosteen peel infuse against S.mutans, the most effectiveinhibition and minimum inhibition. The sample was divided into 10 groups: negativecontrol (K), positive control (K +), and the treatment group of infusa mangosteen rindwith concentration of 100%, 50%, 25%, 12.5%, 6.25%, 3.13%, 1.56% and 0.78%.Negative control group only containing BHI-B. Positive control group containing BHI-B,S.mutans and Tetracycline hydrochloride. The treatment groups containing BHI-B, S.mutans and different concentration of each group. S.mutans colonies was counted usinga colony counter. Data were analyzed with the Kruskal Wallis test followed by Mann-Whitney test. Results of this research showed that infuse mangosteen rind was effectiveas an antibacterial. The most effective concentration which can inhibit S.mutans colonieswas 100% and the minimum concentration was 0.78%.Keywords: Mangosteen peel infuse, antibacteria, Streptococcus mutans, Tetracycline
Co-Authors Amandia Dewi Permana Shita Ayu Mashartini Prihanti Muhamad Martin Widayat Nindya Nur Maghfiroh Oksalani Cahaya Rana