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All Journal Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Narra J
Said A. Khalilullah
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Biochemistry, Genetics & Molecular Biology Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

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Trends antimicrobial resistance in urinary tract infections: a research at the Dr. Zainoel Abidin Teaching Hospital, Banda Aceh, Indonesia Said A. Khalilullah; Devi Susanti; Ramadhan W. Saputra; . Nurjannah
Proceedings of The Annual International Conference, Syiah Kuala University - Life Sciences & Engineering Chapter Vol 1, No 1 (2011): Life Sciences
Publisher : Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (102.841 KB)

Abstract

The aim of this study was to identify the most common bacterial cause of urinary tract infections and the patterns of antimicrobial resistance. The study was conducted at Dr. Zainoel Abidin Teaching Hospital, Banda Aceh, Indonesia with descriptive retrospective study approach.  The data was taken from medical records. One hundred and nineteen bacterials was identified, encountered gram-negative bacteria namely Escherichia coli (31.7%), Klebsiella pneumoniae (27.7%), Acinetobacter (12.6%), Pseudomonas aeruginosa (10.1%), Enterobacter (5.1%) and Proteus mirabilis (0.8%). Meanwhile encountered gram-positive bacteria were Beta-hemolytic Streptococci (9.2%) and Staphylococcus aureus (3.4%). Observations on the sensitivity profile suggested that the pathogenic gram-negative bacteria had a high resistance against ampicilin, ciprofloxacin, cefuroxime and cefotaxime, while meropenem, chloramphenicol, gentamicin and tobramycin have a high sensitivity level. Descriptive analysis also found pathogenic gram-positive bacteria showed high resistance to ceftriaxone, clindamycin, tetracycline and cephalotin and had a high sensitivity level to meropenem, vancomycin and oxacillin. Based on these results we concluded that the most common of urinary tract infections were caused by gram-negative bacteria species Escherichia coli. Encounters a high resistance pattern to 3rd generation cephalosporin antibiotics group, this was caused by the irrational use of antibiotics and the ability of bacteria to produce beta-lactamase enzymes which results in degradation of beta-lactam ring (β-lactam). We recommended the antibiotics group of chloramphenicol, gentamicin and vancomycin to use as empirical therapy in urinary tract infections. Antibiotic treatment should be prescribed only for as long as necessary to be effective. Recurrent urinary tract infections may be managed better by self initiated therapy or prophylaxis than by continuing to treat each case emergently. We also recommend health practitioners to use antibiotics rationally to prevent the resistances.
A potential treatment for erectile dysfunction: Effect of platelet-rich plasma administration on axon and collagen regeneration in cavernous nerve injury Ismy, Jufriady; Khalilullah, Said A.; Maulana, Reza; Hidayatullah, Furqan
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.880

Abstract

Recent studies highlighted the role of platelet-rich plasma (PRP) in progenitor cell homing, migration, and nerve cell regeneration while also inhibiting fibrosis and apoptosis in cavernous nerve injury (CNI). The aim of this study was to investigate the effect of PRP administration on axon and collagen regeneration in CNI. A true experimental study using a post-test-only control group design was conducted. Twenty-five male Wistar rats (Rattus norvegicus), weighing 200–300 grams, were divided into five groups: two control groups (sham procedure and negative control), and three experimental groups receiving local PRP, intraperitoneal PRP, and a combination of local and intraperitoneal PRP. The cavernous nerve was injured with a hemostasis clamp for one minute before 200 µL of 200 PRP was injected locally, intraperitoneally, or both, depending on the group. After four weeks, the rats were euthanized, tissue segments (2 mm) from each cavernous nerve and mid-penis were collected and analyzed for collagen density, axon diameter, and number of myelinated axons. Our study found that collagen growth was slower in CNI group without PRP (sham procedure) compared to all PRP groups (local, intraperitoneal, and combination). The intraperitoneal PRP group had the highest collagen density at 5.62 µm; however, no significant difference was observed in collagen density among all groups (p=0.056). Similar axon diameter was found across the groups, with no statistically significant difference observed (p=0.856). In the number of myelinated axons, a significant difference was found among all groups with significantly more axons in local PRP and combined local and intraperitoneal PRP groups compared to others (p=0.026). In conclusion, PRP administration improved a number of myelinated axons in CNI, suggesting PRP role in CNI regeneration and the potential for an innovative approach to treating erectile dysfunction associated with CNI.
Co-Authors . Nurjannah Devi Susanti Furqan Hidayatullah Ismy, Jufriady Ramadhan W. Saputra Reza Maulana