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All Journal Pharmaciana: Jurnal Kefarmasian
Kartini Kartini
Faculty of Pharmacy University of Surabaya
Medicine & Pharmacology

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Formulation and physical stability test of oleanolic acid cream and gel Kartini Kartini; Endang Wahyu Fitriani; Laurances Tansridjata
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (384.194 KB) | DOI: 10.12928/pharmaciana.v8i1.7336

Abstract

Plantago major has been empirically used for wound healing. One of its chemical compounds, oleanolic acid, exhibited wound healing activity on hyperglycemic rats. The aims of this study were to (1) formulate oleanolic acid into topical dosage forms i.e. cream and gel; and (2) evaluate the physical stability of the products. Oleanolic acid was formulated into the dosage forms using stearic acid, isopropyl palmitate and cetyl alcohol as the cream base and carbomer as the gel base. Cream and gel were then subjected into accelerated (40±2°C/75±5% RH) and room temperature (27±2°C/73±5% RH) stability test for six weeks. Physical stability was determined using parameters of visual appearance, specific gravity, viscosity and flow properties, for both gel and cream, as well as the type of emulsion and particle size for the cream. Data analysis were performed using one-way ANOVA and paired t-test. It is concluded that gel and cream of oleanolic acid were able to maintain their visual appearance, specific gravity, viscosity and flow properties during six weeks of storage. In addition, oleanolic acid cream could also maintain its particle size and type of emulsion during testing. 
Identification of Phyllanthus niruri by FTIR spectroscopy with chemometrics Kartini Kartini; Devi Hardianti; Mochammad Arbi Hadiyat
Pharmaciana Vol 11, No 2 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (372.897 KB) | DOI: 10.12928/pharmaciana.v11i2.15954

Abstract

Phyllanthus niruri (Indonesian: meniran) is a crude drug used in scientific jamu for hyperuricemia, mild hypertension, osteoarthritis, hemorrhoids, and hypercholesterolemia. This plant contains various bioactive compounds such as flavonoids, terpenes, coumarins, lignans, tannins, saponins, alkaloids, etc. Phyllanthus niruri is a wild plant growing in the tropics and sub-tropics of Asia, America, and China. This herb grows well from the lowlands to the highlands, such as bushes, terrain, yards, roadsides, gardens, and rivers. The levels of active compounds in a plant can vary depending on many factors, such as growing location, temperature, humidity, rainfall, and others. This research aimed to evaluate and differentiate P. niruri herbs according to their geographical location using FTIR fingerprint coupled with chemometrics, Principal Component Analysis (PCA) and Cluster Analysis (CA). The results of this study showed that 14 samples of P. niruri are classified into two groups. The first group consists of P. niruri powder originating from Tawangmangu, Kediri, Surabaya, Bangkalan, Gresik, Mojokerto, Kertosono, Krian, Blitar, Nganjuk, unknown 1, unknown 2, and unknown 3, whereas the second group consists of only one sample from Pasuruan. In conclusion, FTIR fingerprint analyzed with chemometrics is adequate to differentiate the powder of P. niruri collected from different locations. FTIR fingerprints combined with chemometrics can be further considered as a method in the quality control process of P. niruri.
Formulation of functional beverages from the combination of lime, tomato, and carrot using foam-mat drying method Kartini Kartini; Alfian Hendra Krisnawan; Lisa Calista Silvanus; Tiffanny Putri Wijaya
Pharmaciana Vol 9, No 2 (2019): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (385.886 KB) | DOI: 10.12928/pharmaciana.v9i2.14134

Abstract

 Lime, tomato, and carrot are natural ingredients widely used both as food and herbal medicines particularly because these plants contain various antioxidant compounds such as vitamin C, phenolics, flavonoids, and carotenoids. Since these materials are easily damaged when exposed to high temperatures, any processing methods that involve slight quality changes in the final product are favorable. This study aimed to formulate lime, tomato, and carrot into functional beverages using foam-mat drying method. Lime juice combined with either tomato paste or carrot juice was mixed with egg white and methylcellulose as foaming agents, then whipped using a mixer for 10 minutes to form a stable foam. The foam was placed in a stainless tray, flattened, and dried in an oven at 60°C for 5 hours. Once dried, the mass was scraped using a spatula, and the resultant dry powder was then evaluated for its physical characteristics and antioxidant activities using nitrite oxide (NO) method. The produced dry mass of lime, lime-tomato (1:1), and lime-carrot (1:1) had organoleptic characteristics, water content, sugar content, and food additives content in accordance with the Indonesian National Standard (SNI). Also, with the IC50 values of 4248, 4931, and 4218 µg/ml, the lime juice and its combination with tomatoes (1:1) and carrots (1:1) can be formulated into functional powder drinks that comply with the SNI quality requirements. Lime-carrot is a better combination than lime-tomato.
Co-Authors Devi Hardianti Endang Wahyu Fitriani Krisnawan, Alfian Hendra Laurances Tansridjata Lisa Calista Silvanus Mochammad Arbi Hadiyat Tiffanny Putri Wijaya