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All Journal Pharmaciana: Jurnal Kefarmasian
Wahyu Widyaningsih
Fakultas Farmasi UAD
Medicine & Pharmacology

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PENGHAMBATAN AKTIVITAS XANTHINE OXIDASE OLEH EKSTRAK ETANOL AKAR SAMBILOTO (Andrographis paniculata, Ness) SECARA IN VITRO Ulfah Septianingsih; Hari Susanti; Wahyu Widyaningsih
Pharmaciana Vol 2, No 2 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (120.217 KB) | DOI: 10.12928/pharmaciana.v2i2.665

Abstract

Sambiloto root of which contained of flavonoids used by the people fortraditional medicine. In the previous publication, an effective xanthine oxidaseinhibitory activity of flavonoids was reported. In research, in vitro xanthine oxidaseinhibitory activity of etanolic root extract of Andrographis paniculata was determinedand Allopurinol was used as a control. The etanolic extract was succesively extractedin a Soxhlet with petroleum eter. Inhibition of xanthine oxidase by etanolic extract wasmeasured the decrease of uric acid production and monitored by spectrophotometer at295 nm with xanthine as substrat. The enzyme inhibitory activity was calculated, andthen IC50 was determined. The result of analyzed with Kruskal Wallis and MannWhitney at 95% confidental level . The flavonoids of etanolic extract were separated onusing by paper chromatography and the spot changing was determined using UV 366with and without amonia.The result of the research showed that the etanolic extract ofAndrographis paniculata inhibited xanthine oxidase activity with IC50 16,54 µg/mlwhile Allopurinol 4,29 µg/ml. The etanolic extract contained flavon or flavonol.
EFEK EKSTRAK ETANOL RIMPANG TEMUGIRING (Curcuma heyneana val) TERHADAP KADAR TRIGLISERIDA Wahyu Widyaningsih
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (92.013 KB) | DOI: 10.12928/pharmaciana.v1i1.516

Abstract

The study of effect ethanolic extract Curcuma heyneana rhizoma as antihypertrigliserida examine of rats after given by dietary of high fat has been carried out. This experiment use 28 white male Wistar grooved rats with weight about 150-200 gram body weight, at about 2 -3 months old. They were divided into seven group randomly and each group 4 rats. The first group was given by standart treatment of dietary (BR II) and aquadest, the second group was given by dietary of high fatty and aquadest, the third group was given by CMC Na solution, the fourth was given by gemfibrosil in CMC Na suspension, the fifth group, the sixth group and the seventh were orally given by of ethanolic extract with dose 10g/kgBW; 20 g/kgBW; and 40 g/kgBW. Hyperlipidemia was treated with higth dietary fatty (5 gram fat cows and 10 gram egg yolk) at the second period (two weeks). The treatment of ethanolic extract Curcuma heyneana rhizoma was given after hyperlipidemia. The trigliserida content determined with GPO (Glycerol-3-Phosphate Oxidase) test. The trigliserida level in the serum analyzed on the before treatment, during the treatment and after treatment. The result of the research showed that ethanolic extract Curcuma heyneana rhizoma 2 weeks can decrease trigliserida level.
Co-Authors Hari Susanti Ulfah Septianingsih