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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Ilmu Kefarmasian Indonesia
Karina Citra Rani
University of Surabaya
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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The effects of croscarmellose sodium concentration on the physicochemical characteristics of orodispersible tablets of atenolol Nani Parfati; Karina Citra Rani
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (2039.681 KB) | DOI: 10.12928/pharmaciana.v8i1.7619

Abstract

Hypertension is the most common cardiovascular diseases suffered by geriatric patients. Their physiological changes make the administration of conventional tablets less effective, especially regarding compliance. One approach to overcome this problem is the development of orodispersible tablets, which soften easily and disintegrate quickly in the oral cavity. Atenolol is a class of β-blocker functioning as an anti-hypertensive drug that has been extensively used in hypertension therapy, and it has the potential to being developed as orodispersible tablets. A faster disintegration of orodispersible tablets will facilitate an earlier onset of dissolution. The addition of superdisintegrants can reduce the disintegration time of these tablets. Croscarmellose sodium is a superdisintegrant that can decrease the disintegration time to less than three minutes. This study aimed to optimize the formula of orodispersible tablets of atenolol using different concentrations of croscarmellose sodium, namely 10% (formula 1) and 20% (formula 2). The physicochemical characteristics of the tablets were evaluated to determine the best formula. The evaluation included a comparison to the control formula (0% of croscarmellose sodium). The results showed that formula 1 (10% of croscarmellose sodium) produced orodispersible tablets with the best physicochemical characteristics regarding tablet hardness, friability, in vitro dispersion time, and disintegration time. Formula 1 (%Q30 minutes= 98.31%) also met the standard of the dissolution of atenolol tablets set by the Farmakope Indonesia, i.e., the percent of dissolved drug in 30 minutes has to be higher than 85%. The drug dissolution efficiency of formula 1 was twice higher than that of the control formula.
Formulasi Granul Sereal Daun Kelor dengan Variasi Jenis Pengikat dan Konsentrasi Xanthan Gum Karina Citra Rani; Nani Parfati; Endang Wahyu Fitriani; Dina Novita Sari; Hilmiyatul Islamia; Tiara Yuni Wulansari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1000

Abstract

Moringa leaves contain macronutrients and micronutrients, potential to be developed into cereal products in the form of granules using the wet granulation method. The type of binder and the concentration of the suspending agent are the main factors that affect the physical characteristics and proximate content of cereals. In this research, 6 formulas of cereal granules were optimized with various types of binders (arrowroot flour, sorghum flour, cornstarch) and variations in the concentration of xanthan gum (0.5% and 1.0%). This study aims to obtain a granule formula of Moringa leaf cereal that meets the requirements of physical, chemical, proximate, and heavy metal characteristics. The results of the evaluation of the granule characteristics showed that all Moringa leaf cereal formulas had good flow characteristics. The results of the evaluation of cereal characteristics after reconstitution showed that cereal granules dispersed quickly (12.58–16.45 seconds), viscosity 73.75 -245 cps, pseudoplastic flow characteristics, and met the pH requirements of food products (5.00-6.00). The results of proximate analysis and metal content showed that all cereal formulas met the SNI requirements for cereal milk (SNI 01-4270-1996) in terms of protein, carbohydrate, ash, lead (Pb), and copper (Cu) content parameters. The most optimal cereal formula is formula 2 because it shows physical characteristics, fat content, carbohydrates, protein, and heavy metals that meet the requirements, as well as crude fiber content (0.76%) which is closest to the requirements (0.7%).
Co-Authors Dina Novita Sari Endang Wahyu Fitriani Hilmiyatul Islamia Nani Parfati Nani Parfati Tiara Yuni Wulansari