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All Journal PROSIDING SEMINAR NASIONAL Indonesian Journal of Cancer
Budiono -
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Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Public Health

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KONTAMINASI SEL DARAH MERAH PADA SISA LARUTAN ANESTESI DALAM CARTRIDGE PASCA INJEKSI ANESTESI LOKAL MENGGUNAKAN SYRINGE INTRALIGAMEN X Moh. Danil Ahsan Murdiputra; Budiono -; Hayyu Failasufa
PROSIDING SEMINAR NASIONAL & INTERNASIONAL 2017: Prosiding Seminar Nasional Publikasi Hasil-Hasil Penelitian dan Pengabdian Masyarakat
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (390.431 KB)

Abstract

Background: Local anesthetic is often used in the dental practice as a pain management to the patient before the surgery procedure. Theories about blood pressure and fluid shows that blood pressure in the vessels can deliver a reverse pressure on the anesthetic solution and it allows blood contamination.Blood as a disease carriers, can deliver blood-borne diseases like HIV, Hepatitis B, malaria, and other infectious disease. The aim of this research is to study red blood cells contamination on the residual anesthetic solution inside the cartridge after local anesthetic injection using X intra-ligament syringe. Methods: Cartridge containing lidocaine hydrochloride 2% and epinephrine 1:80.000 is the material used in this research. Ten cartridges were given to the dentists. The residual anesthetic solution that have been used will be observed in the laboratory. The residual anesthetic solution were observed using Urinalysis Reagent Strips (Urine). This observational analytic research use a cross sectional design and the sampling methods was accidental sampling. Point-biserial correlation were used for data analyze. Results: 33 samples had been obtained from the dentists. The results was 23 samples (69,7%) revealed red blood cells contamination and ten samples (30,3%) didn't reveal red blood cells contamination. There was a close relationship between red blood cells contamination on the residual anesthetic solution (r = - 0,572) and a significant relationship between red blood cells contamination on the residual anesthetic solution with P-value 0,001 (P < 0,01; H0 was rejected). Conclusion: This research conclude that there was red blood cells contamination on the residual anesthetic solution in the cartridge using X intra-ligament syringe. Keywords: red blood cells contamination, residual anesthetic solution, intra-ligament syringe.
Profil Ekspresi Caspase-3 pada Kanker Ovarium Tipe Epitel I Nyoman Gede Budiana; Suhatno -; Faroek Hoesin; Budiono -
Indonesian Journal of Cancer Vol 7, No 3 (2013): Jul - Sep 2013
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (611.688 KB) | DOI: 10.33371/ijoc.v7i3.283

Abstract

Penelitian ini bertujuan mengetahui profil ekspresi caspase-3 pada kanker ovarium tipe epitel. Rancangan penelitian ini adalah cross-sectional deskriptif. Sampel penelitian adalah pasien kanker ovarium di RSUD Dr. Sutomo, Surabaya, yang jaringan tumor ovariumnya telah diparafinisasi di Laboratorium Patologi Anatomi FK Universitas Airlangga Surabaya. Kriteria inklusi adalah blok parafin telah diperiksa secara histopatologi sehingga telah terdiagnosis pasti kanker ovarium tipe epitel dan catatan medis pasien bisa ditemukan serta terisi lengkap. Kriteria eksklusi adalah pasien pernah menjalani kemoterapi atau radiasi sebelum pembedahan dan blok parafin rusak sehingga tidak dapat digunakan. Ekspresi caspase-3 diperiksa secara imunohistokimia.Dari 42 subjek penelitian, didapatkan ekspresi caspase-3 positif sebanyak 47,6% dan ekspresi caspase-3 negatif sebanyak 52,4%. Ditemukan subjek penelitian dengan derajat diferensiasi sel baik lebih banyak mempunyai ekspresi caspase-3 positif dibandingkan dengan derajat diferensiasi sel sedang dan jelek (p=0,017). Subjek penelitian dengan stadium dini lebih banyak mempunyai ekspresi caspase-3 positif (p<0,001). Demikian juga subjek penelitian dengan residu tumor ? 1 cm lebih banyak mempunyai ekspresi caspase-3 positif (p=0,029).Kesimpulan: Terdapat perbedaan yang bermakna secara statistik ekspresi caspase-3 pada berbagai derajat diferensiasi sel, stadium, dan residu tumor pasca operasi primer pada kanker ovarium tipe epitel.Kata kunci: caspase-3, derajat diferensiasi sel, stadium, residu tumor
Co-Authors Failasufa, Hayyu Faroek Hoesin I Nyoman Gede Budiana Moh. Danil Ahsan Murdiputra SUHATNO -