Article Per Year (5 Year)
p-Index From 2020 - 2025
0.659
P-Index
This Author published in this journals
All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Collaborative Medical Journal (CMJ) Klinikal Sains (Jurnal Analis Kesehatan)
Dona Liazarti
Unknown Affiliation
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
KORELASI ANION GAP CALCULATED DENGAN STRONG ION GAP DALAM EVALUASI KEADAAN ASIDOSIS METABOLIK PADA PASIEN CRITICALLY ILL Dona Liazarti; Deinike Marwan; May Valzon
JURNAL KEDOKTERAN DAN KESEHATAN Vol 7, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (243.284 KB) | DOI: 10.32539/JKK.V7I2.11290

Abstract

Asidosis metabolik merupakan gangguan asam basa paling sering pada pasien critically ill dengan penyebab umum berupa peningkatan anion yang tidak terukur. Penilaian adanya anion tidak terukur dapat dilakukan dengan tradisional (AGcalculated ) dan alternatif (SIG). Strong ion gap paling umum digunakan namun membutuhkan sejumlah besar komponen dalam perhitungannya dibandingkan dengan AGcalculated.Penelitian ini bertujuan untuk mengetahui korelasi antara AGcalculated dengan SIG dalam evaluasi keadaan asidosis metabolik pada pasien critically ill. Penelitian dilakukan terhadap 84 pasien critically ill yang dirawat di ICU RSUP Dr. M. Djamil Padang. Analisis gas darah, elektrolit, dan albumin diukur dengan metode potensiometri, amperometri dan spektrofotometri. Analisis bivariat menggunakan uji Spearman untuk mengetahui korelasi antara kadar AGcalculated dengan SIG yang dinyatakan bermakna jika nilai p < 0,05. Rerata nilai pH, pO2, pCO2, Ca ion, HCO3-, BE, Na, K, Cl, dan albumin berturut-turut adalah 7,26(0,1); 193,71(90,26); 36,62(7,77); 0,62(0,16); 17,39(4,36); -9,1(5,11); 134(6,64); 4,19(0,97); 107(5,7); dan 2,43(0,78). Nilai tengah (median) AGcalculated dan SIG adalah 18,52(3,14) dan 7,76(3,31). Uji Spearman menunjukkan korelasi AGcalculated dan SIG memberikan nilai p sebesar 0,001 (p<0,05) yang artinya terdapat hubungan yang bermakna antara AGcalculated dan SIG serta nilai r sebesar 0,997 yang berarti korelasinya sangat kuat, sehingga AGcalculated dapat digunakan untuk menentukan adanya anion yang tidak terukur sebagai penyebab asidosis metabolik di tempat dengan  fasilitas pemeriksaan yang terbatas. Kata kunci: asidosis metabolik, AGcalculated, critically ill, korelasi, SIG   
MEKANISME RESISTENSI TERHADAP ANTI MIKROBA Dona Liazarti
Collaborative Medical Journal Vol 5 No 3 (2022): September
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/cmj.v5i3.3274

Abstract

ABSTRACT Resistance to antimicrobials is the resistance of microorganisms to antimicrobials that were previously effective against infections caused by these microorganisms. Bacterial resistance to antimicrobials can occur with any drug and is a major problem in the treatment of infections in hospitals and in the community. Infections caused by resistant microorganisms often fail standard treatments, resulting in prolonged treatment period, being more expensive, and even causing death. The mechanisms of bacterial resistance to antimicrobials vary and continue to develop, including antimicrobial inactivation, inhibition of entry of antimicrobials to the target site, changes in target molecules where antimicrobials bind, increased production of target molecules and changes in enzymes that activate antimicrobials. Genetic resistance can be intrinsic or acquired. Acquired resistance mechanisms occur through gene mutations then passed down vertically or through horizontal gene transfer. Mutations can occur spontaneously or adaptively, due to substances present in the environment (mutagens) such as chemicals, radiation and ultraviolet light. The main mechanism for the spread of antimicrobial resistance is by horizontal gene transfer. Genetic material that is transferred in a mobile form is in the form of plasmids, transposons and integrons and can be transferred by various mechanisms including conjugation, transformation and transduction.
HUBUNGAN PARAMETER HEMATOLOGI DENGAN HASIL SWAB PCR PASIEN COVID-19 Dona liazarti; May Valzon
Klinikal Sains : Jurnal Analis Kesehatan Vol 11 No 2 (2023): Desember
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v11i2.3481

Abstract

The gold standard for diagnosing COVID-19 is PCR examination, but it is difficult to implement. The earliest routine laboratory examinations requested by clinicians were hematology including hemoglobin, leukocytes, platelets, ALC and NLR. This examination is inexpensive and easy to obtain. This study aims to evaluate the relationship between hematological parameters and PCR results in patients with suspected COVID-19. The study had a cross-sectional design by conducting hematological examinations on suspected Covid-19 patients undergoing PCR swabs. The study used two specimens; first, naso/oropharyngeal swab for PCR examination; second, venous blood with EDTA anticoagulant for examination of hemoglobin, leukocytes, platelets, NLR and ALC using an automated hematology equipment. Univariate analysis was performed to determine the mean and standard deviation. Independent variable data were tested by Kolmogorov-Smirnov which were then analyzed bivariately by independent t test. The mean age of the research subjects was 48.94 years. Most of the subjects who underwent PCR swab examination were women (63%) with positive PCR swab results of 88%. The mean NLR parameter was higher in patients with positive PCR than in patients with negative PCR with p value =0.025 (p<0.05). The NLR parameter was significantly higher in patients with positive PCR so that it can be used as a guideline for clinicians in the initial evaluation of patients with suspected Covid-19.
Co-Authors Deinike Marwan Valzon, May