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All Journal E-Jurnal Medika Udayana
Dewa Nyoman Krisna Arijaya
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Health Professions Medicine & Pharmacology

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CLOZAPINE ON PARANOID SCHIZOPHRENIA WITH OBESITY: A CASE REPORT Dewa Nyoman Krisna Arijaya
E-Jurnal Medika Udayana vol 3 no 4 (2014):e-jurnal medika udayana
Publisher : Universitas Udayana

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Abstract

Treatments   of   schizophrenia   using   atypical   antipsychotics   provide   remission   of symptoms and side effects differ between individuals. The use of the method by findingthe right medication often has an impact on patient adherence to treatment. In the caseof  a  female  patient  aged  26  years  was  diagnosed  with  paranoid  schizophrenia  andclozapine  treatment  using  2x25  mg  for  6  months.  Schizophrenic   symptoms  hadsubsided  and  the  patient  can  work,  but  the  treatment  was  stopped  by  the  parents.Treatment was discontinued because of patient body weight increased to 80 kg frominitial weight 65 kg. Clozapine increases the weight by several mechanisms.  Geneticand environmental influences susceptibility to gain weight. Weight gain can also causea large enough increase in obesity-related comorbidities and health risks such as type IIdiabetes mellitus, hypertension, hear t  disease and cancer.  Subsequent  treatment  bechanged  using  atypical  antipsychotics  risperidone  at  a  dose  equivalent.  Given alsoeducate and maintain compliance with treatment.
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