Garuda - Garba Rujukan Digital

Analysis of Carbon Monoxide Exposure and Its Effect to Lung Function of Parking Officer in Basement Mal X Pekanbaru Indi Esha; Dedi Afandi; Viktor Amrifo
Jurnal Ilmu Lingkungan Vol 11, No 1 (2017): Jurnal Ilmu Lingkungan
Publisher : Program Pascasarjana Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/jil.11.1.p.25-34

A Study on the effect of carbon monoxide exposure on lung function of parking officers in basement Mall X Pekanbaru were carried out in January 2017. The research aim at describing carbon monoxide air ambient in basement Mall X Pekanbaru as well as respiratory state of parking officers and analysing carbon monoxide exposure and lung function relationship. The result showed that carbon monoxide concentration ranged from 2,8 – 11,5 ppm with average of 6,23 ppm. Apparently carbon monoxide exposure had significant correlation (r = -0,795) with lung function of parking officers in basement of the Mall X Pekanbaru. Respiration state of the parking officers account for 16,7% impaired lung function examined by spirometri. Working period more than 1 year related to that of impaired lung function. Other factors such as used of self protection device, smoking habit, medical record showed a significant correlation with lung function.

The Effects of Carbon Monoxide and Lead Exposure on Lung Function: A Meta-Analysis Yumanda, Anggie; Indi Esha
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 11 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i11.1123

Background: Carbon monoxide (CO) and lead (Pb) are ubiquitous environmental pollutants with well-established detrimental health effects. The impact of these pollutants on lung function, a critical indicator of respiratory health, has been investigated in numerous studies. However, the findings have been inconsistent, necessitating a comprehensive meta-analysis to synthesize the evidence and provide a definitive assessment. Methods: A systematic search of electronic databases (PubMed, Scopus, Web of Science) was conducted to identify relevant studies published between 2018 and 2024. Studies investigating the association between CO and Pb exposure and lung function, measured by spirometry (Forced Expiratory Volume in 1 second [FEV1] and Forced Vital Capacity [FVC]), were included. A random-effects model was used to pool the effect estimates, and heterogeneity was assessed using the I² statistic. Results: The meta-analysis included 25 studies (n = 15,432 participants). The pooled results demonstrated a significant negative association between CO exposure and both FEV1 (standardized mean difference [SMD] = -0.32, 95% confidence interval [CI] = -0.45 to -0.19, p < 0.001) and FVC (SMD = -0.27, 95% CI = -0.38 to -0.16, p < 0.001). Similarly, Pb exposure was associated with a significant reduction in FEV1 (SMD = -0.21, 95% CI = -0.30 to -0.12, p < 0.001). The heterogeneity across studies was moderate to high (I² = 50-75%). Conclusion: This meta-analysis provides compelling evidence that both CO and Pb exposure are associated with impaired lung function. These findings underscore the importance of reducing exposure to these pollutants to protect respiratory health.

Predictive Value of Circulating Pro-Fibrotic Cytokines for Progression in Idiopathic Pulmonary Fibrosis and Progressive Pulmonary Fibrosis (PPF): A Systematic Review and Meta-Analysis Yolanda Julia Perel Putri; Indi Esha; Dewi Wijaya
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 8 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i8.1368

Background: The clinical trajectory of patients with idiopathic pulmonary fibrosis (IPF) and the broader phenotype of progressive pulmonary fibrosis (PPF) is highly variable. Current prognostic models lack precision, highlighting an urgent need for reliable biomarkers. Circulating pro-fibrotic cytokines are implicated in fibrogenesis, but their individual predictive utility for disease progression remains debated. This systematic review and meta-analysis were conducted to synthesize the available evidence and quantify the predictive value of key circulating pro-fibrotic cytokines for disease progression in patients with IPF and PPF. Methods: A systematic literature search was performed in PubMed, Embase, and Scopus databases for studies published between January 1st, 2014, and December 31st, 2024. We included longitudinal cohort studies that evaluated the association between baseline circulating levels of Transforming Growth Factor-beta 1 (TGF-β1), Chemokine Ligand 18 (CCL18), or Interleukin-6 (IL-6) and a composite endpoint of disease progression (all-cause mortality, lung transplantation, or a significant decline in Forced Vital Capacity [FVC]). Hazard Ratios (HRs) and their 95% Confidence Intervals (CIs) were extracted. A random-effects model was used to pool the data. Heterogeneity was assessed using the I² statistic, and publication bias was evaluated with funnel plots and Egger’s test. Results: The search yielded 1,842 citations, from which seven studies comprising a total of 1,158 patients met the inclusion criteria. Elevated baseline levels of all three cytokines were significantly associated with an increased risk of disease progression. The pooled HR for TGF-β1 (4 studies, 650 patients) was 2.15 (95% CI: 1.55-2.98, p < 0.001), with moderate heterogeneity (I² = 55%). For CCL18 (5 studies, 812 patients), the pooled HR was 1.98 (95% CI: 1.41-2.78, p < 0.001), with substantial heterogeneity (I² = 68%). For IL-6 (3 studies, 515 patients), the pooled HR was 2.41 (95% CI: 1.78-3.26, p < 0.001), with low heterogeneity (I² = 21%). Subgroup analysis suggested a consistent predictive effect across both IPF and non-IPF PPF cohorts. Conclusion: This meta-analysis provides robust evidence that elevated circulating levels of TGF-β1, CCL18, and IL-6 are potent and independent predictors of disease progression in patients with IPF and PPF. These biomarkers hold significant promise for enhancing patient risk stratification, improving prognostic accuracy, and guiding personalized therapeutic decisions in clinical practice.

Predictive Value of Circulating Pro-Fibrotic Cytokines for Progression in Idiopathic Pulmonary Fibrosis and Progressive Pulmonary Fibrosis (PPF): A Systematic Review and Meta-Analysis Yolanda Julia Perel Putri; Indi Esha; Dewi Wijaya
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 8 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i8.1368

Background: The clinical trajectory of patients with idiopathic pulmonary fibrosis (IPF) and the broader phenotype of progressive pulmonary fibrosis (PPF) is highly variable. Current prognostic models lack precision, highlighting an urgent need for reliable biomarkers. Circulating pro-fibrotic cytokines are implicated in fibrogenesis, but their individual predictive utility for disease progression remains debated. This systematic review and meta-analysis were conducted to synthesize the available evidence and quantify the predictive value of key circulating pro-fibrotic cytokines for disease progression in patients with IPF and PPF. Methods: A systematic literature search was performed in PubMed, Embase, and Scopus databases for studies published between January 1st, 2014, and December 31st, 2024. We included longitudinal cohort studies that evaluated the association between baseline circulating levels of Transforming Growth Factor-beta 1 (TGF-β1), Chemokine Ligand 18 (CCL18), or Interleukin-6 (IL-6) and a composite endpoint of disease progression (all-cause mortality, lung transplantation, or a significant decline in Forced Vital Capacity [FVC]). Hazard Ratios (HRs) and their 95% Confidence Intervals (CIs) were extracted. A random-effects model was used to pool the data. Heterogeneity was assessed using the I² statistic, and publication bias was evaluated with funnel plots and Egger’s test. Results: The search yielded 1,842 citations, from which seven studies comprising a total of 1,158 patients met the inclusion criteria. Elevated baseline levels of all three cytokines were significantly associated with an increased risk of disease progression. The pooled HR for TGF-β1 (4 studies, 650 patients) was 2.15 (95% CI: 1.55-2.98, p < 0.001), with moderate heterogeneity (I² = 55%). For CCL18 (5 studies, 812 patients), the pooled HR was 1.98 (95% CI: 1.41-2.78, p < 0.001), with substantial heterogeneity (I² = 68%). For IL-6 (3 studies, 515 patients), the pooled HR was 2.41 (95% CI: 1.78-3.26, p < 0.001), with low heterogeneity (I² = 21%). Subgroup analysis suggested a consistent predictive effect across both IPF and non-IPF PPF cohorts. Conclusion: This meta-analysis provides robust evidence that elevated circulating levels of TGF-β1, CCL18, and IL-6 are potent and independent predictors of disease progression in patients with IPF and PPF. These biomarkers hold significant promise for enhancing patient risk stratification, improving prognostic accuracy, and guiding personalized therapeutic decisions in clinical practice.

Thoracic Ultrasound: A Narrative Literature Review Atikanur; Indi Esha
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 3 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i3.933

Ultrasonography (USG) is useful in diagnosing abnormalities in the thoracic area, such as pleural effusion, pneumothorax, consolidation, atelectasis, pulmonary edema, etc. The advantages of thoracic ultrasound are low cost, non-radiation, non-invasive, easy to carry, short examination time, and a dynamic aspect that can be seen during the examination. Thoracic ultrasound can be used to guide thoracentesis procedures, chest tube placement, and aspiration of lung abscesses. Ultrasound can be substituted as a computed tomography scan (CT-Scan) as a guide for aspiration and biopsy of the lung parenchyma, pleura, and chest wall. Portable and compact ultrasonography provides the opportunity for ultrasound examinations to become a routine part of an examination, like a stethoscope. Ultrasonography also has limitations in patients with subcutaneous emphysema, peripheral edema, and obesity. Ultrasound examination is very dependent on the experience and abilities of the operator.

Thoracic Ultrasound: A Narrative Literature Review Atikanur; Indi Esha
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 3 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i3.933

Ultrasonography (USG) is useful in diagnosing abnormalities in the thoracic area, such as pleural effusion, pneumothorax, consolidation, atelectasis, pulmonary edema, etc. The advantages of thoracic ultrasound are low cost, non-radiation, non-invasive, easy to carry, short examination time, and a dynamic aspect that can be seen during the examination. Thoracic ultrasound can be used to guide thoracentesis procedures, chest tube placement, and aspiration of lung abscesses. Ultrasound can be substituted as a computed tomography scan (CT-Scan) as a guide for aspiration and biopsy of the lung parenchyma, pleura, and chest wall. Portable and compact ultrasonography provides the opportunity for ultrasound examinations to become a routine part of an examination, like a stethoscope. Ultrasonography also has limitations in patients with subcutaneous emphysema, peripheral edema, and obesity. Ultrasound examination is very dependent on the experience and abilities of the operator.

The Effects of Carbon Monoxide and Lead Exposure on Lung Function: A Meta-Analysis Yumanda, Anggie; Indi Esha
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 11 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i11.1123

Background: Carbon monoxide (CO) and lead (Pb) are ubiquitous environmental pollutants with well-established detrimental health effects. The impact of these pollutants on lung function, a critical indicator of respiratory health, has been investigated in numerous studies. However, the findings have been inconsistent, necessitating a comprehensive meta-analysis to synthesize the evidence and provide a definitive assessment. Methods: A systematic search of electronic databases (PubMed, Scopus, Web of Science) was conducted to identify relevant studies published between 2018 and 2024. Studies investigating the association between CO and Pb exposure and lung function, measured by spirometry (Forced Expiratory Volume in 1 second [FEV1] and Forced Vital Capacity [FVC]), were included. A random-effects model was used to pool the effect estimates, and heterogeneity was assessed using the I² statistic. Results: The meta-analysis included 25 studies (n = 15,432 participants). The pooled results demonstrated a significant negative association between CO exposure and both FEV1 (standardized mean difference [SMD] = -0.32, 95% confidence interval [CI] = -0.45 to -0.19, p < 0.001) and FVC (SMD = -0.27, 95% CI = -0.38 to -0.16, p < 0.001). Similarly, Pb exposure was associated with a significant reduction in FEV1 (SMD = -0.21, 95% CI = -0.30 to -0.12, p < 0.001). The heterogeneity across studies was moderate to high (I² = 50-75%). Conclusion: This meta-analysis provides compelling evidence that both CO and Pb exposure are associated with impaired lung function. These findings underscore the importance of reducing exposure to these pollutants to protect respiratory health.

Title

Found 7 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 7 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 7 Documents
Search