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All Journal INDONESIAN JOURNAL OF LEGAL AND FORENSIC SCIENCES Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva
Dita Septiani
Universitas Indonesia
Chemistry Dentistry Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology

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Journal : INDONESIAN JOURNAL OF LEGAL AND FORENSIC SCIENCES

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GENOTOKSISITAS CHLOREXIDINE DITA SEPTIANI
Indonesian Journal of Legal and Forensic Sciences (IJLFS) Vol 10 No 1 (2020): Indonesian Journal of Legal and Forensic Sciences
Publisher : Penerbit, sejak 2012 : Asosiasi Ilmu Forensik Indonesia dan UPT Lab. Forensik Sain dan Kriminilogi - Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/IJLFS.2020.v10.i01.p06

Abstract

Chlorexidine is a mouthwash that is chosen by many dentists as an antiseptic and antibacterial. CHX has bactericidal properties in gram-positive and negative bacteria and fungi. Chlorhexidine causes damage to the permeability of bacterial cell membranes so that cytoplasmic fluid in bacterial cells and other cell components with lower molecular weight from inside the cell penetrates out through the cell membrane, causing the bacteria to die. Much research has been done to study the biocompatibility of composite resins, especially cytotoxicity and genotoxicity testing. Genotoxicity tests that are often done are comet tests to see DNA damage and micronuclei tests to see genome damage. CHX increases Fe-dependent lipid peroxidation by splitting oxygen bonds with iron ions in Fentonlike reactions, producing alkoxyl radicals. The ROS reaction of unsaturated lipids on cell membranes and plasma lipoproteins results in the formation of lipid peroxide (malondialdehyde) which can chemically alter proteins and bases nucleic acid. The content of chlorexidine can have genotoxic effects. Keyword: Genotoxic, Chlorexidine, comet assay, micronuclei assay
Co-Authors Afifah B. Sutjiatmo Euis Reni Yuslianti, Euis