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HMS. Chandra Kusuma
Laboratorium Ilmu Kesehatan Anak Fakultas KedokteranUniversitas Brawijaya / RSU dr. Saiful Anwar Malang
Medicine & Pharmacology

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Journal : Jurnal Kedokteran Brawijaya

 1 
HUBUNGAN ANTARA DERAJAT OBSTRUKSI SERANGAN AKUT ASMA DENGAN KADAR IgE, IFN- DAN IL-4 TOTAL SERUM Kusuma, HMS. Chandra; Kalim, Kusworini Handono; Riawan, Wibi; Muid, Masdar
Jurnal Kedokteran Brawijaya Vol 20, No 2 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (119.883 KB) | DOI: 10.21776/ub.jkb.2004.020.02.4

Abstract

ABSTRACT Acute bronchial asthma is a common medical emergency the world over. There now exists compelling evidence of a role for Th2-Th1 paradigm in the pathogenesis of asthma in children. We hypothesized that childhood asthma is associated with the activation of  Th2-Th1 lymphocytes whose products regulate at least in part, the expression of IgE, IFN-γ and IL-4 and thereby disease severity. Our aims, therefore were to compare the level of total IgE, total IL-4 and total IFN-γ in serum from asthmatic and non asthmatic control children matched for age and sex, and to attempt to correlate the IgE, IL-4, and IFN-γ total level of serum in the asthmatics children with disease severity. Fifty one children with acute asthma exacerbation were compare with thirty one no asthmatics normal children matched for age and sex. The level of IgE, IL-4, and IFN-γ were measured using Elisa. Asthma severity was assessed by a symptom score and spirometri. The level of IgE and Il-4 in the serum of the asthma were elevated as compared to the non asthmatic normal controls, whereas the IFN-γ was decreased. There was a significant correlation between elevated levels of IgE and IL-4 with the acute asthma exacerbation severity, whereas the decreased level of IFN-γ was not. Conclusions. The increased levels of IgE , IL-4 and the ratio of  IL-4/IFN-γ play a crucial role in the acute asthma exacerbation severity.
PREDIKTOR ASMA PADA USIA 7 TAHUN SETELAH MENDERITA BRONKIOLITIS AKUT KARENA RESPIRATORY SYNCYTIAL VIRUS: SUATU STUDI PROSPEKTIF Kusuma, HMS. Chandra
Jurnal Kedokteran Brawijaya Vol 22, No 3 (2006)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (108.815 KB) | DOI: 10.21776/ub.jkb.2006.022.03.7

Abstract

Infants are at increased risk of developing asthma  after RSV (Respiratory Syncytial Virus) acute bronchiolitis. The hypothesis that cytokine production is related to the development of asthma after RSV bronchiolitis. The diagnosis of RSV bronchiolitis was verified using the Abbott test pack RSV, a rapid enzyme immuno assay for direct detection of viral antigen in nasopharyngeal secretion. Changes in FEV1 (Forced Expiratory Volume in 1 second) were determined using spirometri, IL-4 and IFN-γlevels were determined using the enzyme-linked immunosorbant assay (ELISA) method. In this study, 62 children hospitalized for RSV bronchiolitis were followed prospectively, 55 (88.7%) childrencompleted the study and 41 children (74.5%) had asthma at 7 years of age. RSV bronchiolitis children were more frequent among boys (boy /girl ratio: 2). Episodes of wheezing more than 8 had specifity and sensitivity of 100% respectivelly,might be the very useful predictor for asthma. The cut off level over 40.84 pg/ml for IL-4, below 14.12 pg/ml for IFN-γ, IL-4 / IFN-γratio over 3 and episodes of wheezing over 8 may be used to predict asthma after RCV bronchiolitis.
HUBUNGAN ANTARA DERAJAT OBSTRUKSI SALURAN NAFAS SERANGAN AKUT ASMA DENGAN JUMLAH SEL-SEL INFLAMASI DARAH TEPI Kusuma, HMS. Chandra; Kalim, Kusworini Handono; Muid, Masdar
Jurnal Kedokteran Brawijaya Vol 20, No 3 (2004)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (449.483 KB) | DOI: 10.21776/ub.jkb.2004.020.03.5

Abstract

There now exists compelling evidence of a role for  cell-mediated immunity in the pathogenesis of asthma, but little information is available as to what extent this process participates in the disease severity. The hypothesized of this reseach that the severity of acute asthma exacerbation in children is associatedwith the activation of T-lymphocytes whose products regulate, at least in part, the mobilization and recruitment of eosinophyls and thereby disease severity. The aims of this research, therefore, were to compare the peripheral blood T-lymphocytes from acute asthmaticand no asthmatic normal control children matched for age and sex, and to attempt to correlate the percentages of T-lymphocytes in the asthmatic with the numbers of peripheral  blood eosinophyls and with disease severity. Fifty one children with acute asthma exacerbation were compared with thirty one no asthmatic, normal children matched for age and sex. Peripheral blood CD4+ and  CD8+ T-lymphocytes was measured using immuno histochemical staining. Peripheral blood eosinophils were measured using anautomated laser cytometer. Asthma exacerbation severity was assessed by a symptom score and spirometri. The absolute numbers  of eosinophils and CD4+ T-lymphocytes of the asthmatic were elevated as compared to the non-asthmatic normal control, whereas the numbers of CD8+ T-lymphocyte decreased significantly.
Co-Authors Kusworini Handono Kalim Masdar Muid Wibi Riawan