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All Journal Majalah Obat Tradisional
Wahyu Widyaningsih
Faculty of Pharmacy, Universitas Ahmad Dahlan
Health Professions Medicine & Pharmacology Public Health

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EFEK ANTIANGIOGENESI EKSTRAK ETANOL GANGGANG HIJAU (Spirogyra sp.) BERDASARKAN EKSPRESI COX-2 PADA SEL T47D Wahyu Widyaningsih; Nina Salamah; Hari Susanti; Dwi Fitriani
Majalah Obat Tradisional Vol 19, No 3 (2014)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (974.752 KB) | DOI: 10.22146/tradmedj.8229

Abstract

Cancer is a group of diseases that arise when a cell or group of cells that regulate out of control growth. Green algae (Spirogyra sp.) is one of the medicinal plants used in traditional medicine for the treatment of cancer. Green algae (Spirogyra sp.) has active substances such as melatonin. Melatonin which is a compound that has been examined by researchers world as anticancer drugs and antioxidants. This study aims to determine the effect of ethanol extract of green algae (Spirogyra sp.) on the expression of COX - 2 in T47D cells. Green algae was extracted using a Soxhlet apparatus with 96 % ethanol. This study used three groups: control cells , ethanol extract of green algae concentrations 247.668 ug / mL and 123.834 mg / mL. To ensure the expression of caspase-3 and Bcl-2, test was conducted using indirect immunocytochemistry. Observations were carried out using a light microscope to see and count the percent expression of COX - 2. The results obtained showed significant difference, decreased expression of COX - 2 in each group. It can be concluded that the ethanol extract of green algae (Spirogyra sp.) decreased COX - 2 expression in T47D cells.
Co-Authors Desyandri Desyandri Dwi Fitriani Hari Susanti