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All Journal Majalah Obat Tradisional JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA JPSriwijaya FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Abdi Insani
Elsa Fitria Apriani
Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Sriwijaya University, South Sumatra, Indonesia
Agriculture, Biological Sciences & Forestry Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Public Health Other

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Hair Growth Promoting Activity of Green Tea Leaves (Camellia sinensis l.) Ethanolic Extract Vini Noviani; Shelly Thauresia; Elsa Fitria Apriani; Partomuan Simanjuntak
Majalah Obat Tradisional Vol 24, No 2 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.44053

Abstract

Hair loss and baldness is one of the abnormalities in the hair that often occurs in both men and women. Many cosmetic products from natural to synthetic materials have been developed to overcome these problems, yet, synthetics product is potential to give side effects, such as local irritation. In this study, green tea (Camellia sinensis L.) leaves were used as active substances. The aim of this study was to attest the hair growth promoting activity of n-hexane, water, and ethyl acetate fractions from ethanolic extract of green tea leaves. Green tea leaves contain flavonoids which can help promoting hair growth. To obtain the compound, green tea leaves were made into ethanolic extract. The extract was obtained by maceration using 70% ethanol then partitioned using n-hexane, ethyl acetate, and water, to obtain the n-hexane, ethyl acetate, and water fractions. Ethyl acetate and water fractions have been shown to contain flavonoids, so it could continue the hair growth promoting activities with concentrations of 1% and 4%. Hair growth promoting activity was performed on rabbits. The results showed that 4% of water fraction containing flavonoids had the best hair growth promoting activity.
Formulation and Evaluation of Water Fraction Hair tonic Containing Flavonoids from Ethanolic Extract of Green Tea Leaves (Camellia sinensis L.) Elsa Fitria Apriani; Adik Ahmadi; Vini Noviani
Majalah Obat Tradisional Vol 26, No 2 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.53665

Abstract

Hair growth tonics containing herbal and synthetic ingredients have been developed to overcome hair loss and baldness. Advanced technological developments made many Indonesians prefer to use herbal products compared to synthetic products due to their fewer side effects. Green tea leaves (Camellia sinensis L.) is a plant believed to increase hair growth rates due to its flavonoid compounds. The purpose of this study is to formulate hair tonic from water fraction ethanolic extract green tea leaves, to look at the activity of hair growth-promoting, and also to look at physical stability, irritation tests, and microbial contamination.  The positive control used is 2% Minoxidil. The hair growth activity test was carried out by applying a hair tonic to rabbits. Hair growth measurement data were statistically tested by the ANOVA test. The formulated green tea leaves tonic met the physical properties test. The tonic produces similar growth activities with the positive control (significance difference (p> 0.05)). In addition, the tonic does not have a skin irritation effect on rabbit skin and is free from bacteria.
Development of Nanoparticles Pegagan Leaves Ethanolic Extract (centella asiatica (L.) Urban) using Variation Concentration of Poly-Lactic-CO-Glycolic Acid (PLGA) Polymer Elsa Fitria Apriani; Mardiyanto Mardiyanto; Rika Destiana
Majalah Obat Tradisional Vol 27, No 1 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.73513

Abstract

Pegagan is a plant that plays an important role in health because of its secondary metabolite. However, many secondary metabolites tend to be unstable when exposed to UV light and oxygen such as flavonoid and terpenoid. The purpose of this study was to formulate the ethanolic extract of pegagan leaves into nanoparticle preparations to increase the stability of the extract. Nanoparticle preparations were made using the emulsion solvent evaporation method using Poly-Lactic-Co-Glycolic Acid (PLGA) and polyvinyl alcohol (PVA). PLGA acts as a polymer that will coat the extract and PVA as a stabilizer. Variations in the concentration of PLGA used were 50 mg, 75 mg, and 100 mg, while the concentration of PVA used was 40 mg and the extract concentration was 158 mg. Determination of the best formula is done by looking at the results of the percent encapsulation efficiency obtained from the three formulas, namely 93.68%, 85.35%, and 88.76%, respectively. Based on these results, formula 1 was determined as the best formula. The particle size obtained in the best formula was 288.1667±3.4195 nm, the polydispersity index (PDI) was 0.371±0.0045 and the zeta potential value was -10.6333±0.1154. A physical stability test (cycling test method) of the best formula found a decrease in pH of 0.54 and no organoleptic changes or precipitate formed.
PEMANFAATAN APPLE CIDER VINEGAR SEBAGAI ANTISEPTIK ALTERNATIF UNTUK PEMBUATAN HAND SANITIZIER DALAM PENERAPAN PERILAKU HYGIENE PADA MASA PANDEMI COVID-19 DI DESA PULAU SEMAMBU INDRALAYA Adik Ahmadi; Elsa Fitria Apriani; Fidel Harmanda Prima; Akhyar Dyni Zakyah
Jurnal Pengabdian Sriwijaya Vol 9, No 1 (2021)
Publisher : Lembaga Pengabdian pada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37061/jps.v9i1.13185

Abstract

Pandemi Covid-19 saat ini terus mengalami peningkatan kasus. Salah satu cara untuk memutus mata rantai penyebaran Covid-19 adalah menerapkan perilaku bersih dan hygiene melalui pemanfaatan handsanitizer. Handsanitizer saat ini lebih banyak digunakan dan disukai untuk membersihkan tangan karena praktis dalam penggunaan dan penyimpanan. Ada banyak bahan alami yang bisa kita manfaatkan dalam pembuatan handsanitizer salah satunya cuka apel. Cuka apel telah lama diketahui berkhasiat sebagai antiseptik dan meningkatkan daya tahan tubuh. Bahan ini mudah didapatkan dan bisa menjadi bahan alternatif sebagai antiseptik alami terutama pada masyarakat pedesaan yang tidak banyak menggunakan handsanitizer. Sasaran pelaksanaan kegiatan ini adalah masyarakat desa Pulau Semambu, Indralaya, Kabupaten Ogan Ilir, Sumatra Selatan yang berada dekat dengan Universitas Sriwijaya sehingga sangat cocok diberikan penyuluhan. Kegiatan ini dilaksanakan dalam bentuk penyuluhan secara langsung diikuti diskusi terkait preparasi produk dan diakhiri dengan evaluasi di akhir kegiatan. Diharapkan dengan adanya kegiatan ini bisa meningkatkan pemahaman dan pengetahuan masyarakat tentang sediaan handsanitizer dan penerapan perilaku bersih dan hygiene pada masa normal baru di lingkungan masyarakat sekitar.
Formulation and Characterization of Transfersomal Containing Breadfruit Leaves (Artocarpus altilis (Park.) Fsb.) Ethanolic Extract Elsa Fitria Apriani; Fitrya Fitrya; Hannan Hanifah
FITOFARMAKA: Jurnal Ilmiah Farmasi Vol 12, No 2 (2022): FITOFARMAKA: Jurnal Ilmiah Farmasi
Publisher : Universitas Pakuan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33751/jf.v12i2.4736

Abstract

Breadfruit (Artocarpus altilis (Park.) Fsb.) leaves have anti-tyrosinase activity due to their flavonoid content. Anti-tyrosinase penetration is deep because the tyrosinase process occurs in the stratum basale. This study aimed to formulate and characterize the transfersomal containing breadfruit (Artocarpus altilis (Park.) Fsb.) leaves ethanolic extract with varying concentrations of Tween 80 and Phospholipon 90G. Breadfruit leaves were extracted using 96% ethanol and quantitative measures of flavonoid content. Breadfruit leaves extract was then formulated into transfersomes using the thin layer hydration method with a concentration ratio of Tween 80 and Phospholipon 90G, respectively, of 5:95; 10:90; 15:85; 20:80; and 25:75. The resulting transfersomes were then characterized by the value of entrapment efficiency (EE), polydispersity index, particle size, and zeta potential to determine the best formula. The %EE result for the 5th formula were 95.13%; 95.42%; 92.78%; 90.48%; and 87.58. The polydispersity result respectively were 0.232; 0.427; 0.236; 0.425; and 0.292. The particle sizes were 276.13 nm, 290.70nm, 222.13nm, 320.80nm, and 280.90 nm. Meanwhile, the zeta potential values respectively were -15.1; -18.2 mV; -20.5 mV; -36.9 mV; and -16.7mV. The concentrations of 20% Tween 80 and 80% Phospholipon 90G were chosen as the best formulas based on the results of their characterization. The best formula also showed a spherical morphology and was most stable with the lowest reduction of entrapment efficiency of 1.7416±0.2033%.
Viability and Antibacterial Activity of Bifidobacterium bifidum in Fermented Robusta Coffee for Diarrhea Treatment Miksusanti; Elsa Fitria Apriani; Dimas Nur Hidayat
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 9 No. 3 (2022): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v9i32022.305-313

Abstract

Background: Diarrhea can be treated with probiotic bacteria such as Bifidobacterium bifidum, which decreases the intestinal environment's pH to become acidic so that pathogenic bacteria cannot thrive. Objective: To make fermented coffee that can increase the number of probiotic bacteria Bifidobacterium bifidum and has antidiarrheal activity against pathogenic bacteria Escherichia coli. Methods: Robusta coffee (20.25% and 19.75%) was fermented using Saccharomyces cerevisiae, and then the probiotic bacteria Bifidobacterium bifidum was added. Unfermented coffee was compared with the same concentration (20.25% and 19.75%) to obtain four formulas. Organoleptic panelists tested all formulas to determine the best formula for fermented and non-fermented coffee. The number of Bifidobacterium bifidum and antibacterial activity was calculated on the optimum formulation using the Total Plate Count and Disc Diffusion Method. Result: The optimum formula obtained at fermented and unfermented coffee concentration was 20,25%. The number of probiotic bacteria Bifidobacterium bifidum growing in fermented and non-fermented coffee was 7.3 x 108 ± 32.4 and 3.1 x 108 ± 30.7 (p < 0.05). The diameter of the inhibition zone of the best fermented and non-fermented coffee was 11.5 ± 0.5 mm and 8.5 ± 0.5 mm, respectively (p < 0.05). Conclusion: Fermented coffee can increase the growth of the probiotic bacteria Bifidobacterium bifidum and has strong antibacterial activity against Escherichia coli bacteria.
PENDAMPINGAN PEMBUATAN TRAVELLING PAPER SOAP UNTUK MENINGKATKAN SANITASI ENDEMIK COVID-19 PADA MASYARAKAT DI DESA TANJUNG PERING SUMATERA SELATAN Elsa Fitria Apriani; Dwi Hardestyariki; Adik Ahmadi; Viva Starlista
Jurnal Abdi Insani Vol 10 No 1 (2023): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v10i1.812

Abstract

The decline in COVID-19 cases in Indonesia indicates that the pandemic status is starting to transition towards endemic. Endemic to COVID-19 does not mean that the COVID-19 virus has completely disappeared, so people still need to maintain a healthy lifestyle, one of which is maintaining sanitation. The use of soap is considered impractical so it is necessary to innovate sanitary products in the form of traveling paper soap in the form of paper soap which is easy to carry anywhere. The purpose of this service is to provide assistance in making mobile paper soap to improve sanitation endemic to COVID-19 and to help improve the skills and economy of the community in Tanjung Pering Village, South Sumatra. The community service method used in this activity is in the form of practice, counseling, technical guidance and assistance. The service was carried out in approximately 2 months for PKK mothers in Tanjung Pering Village, South Sumatra. Prior to the assistance, an introduction was given regarding the importance of washing hands with soap during this endemic period of COVID-19. Many PKK mothers do not understand the importance of using soap and prefer to use hand sanitizers which they feel are practical to carry anywhere. The manufacturing process is simple so that in the future PKK mothers can apply it themselves at home and it can become a platform for new businesses to develop. In addition, the traveling paper soap product that has been made can be used to tackle the problem of COVID-19 transmission during this endemic period. PKK mothers' understanding of the importance of using soap has increased after this service and PKK mothers have gained skills in making Traveling Paper Soap products.
In Vitro Release Ability of Nanoparticles Poly-Lactic-Co-Glycolic-Acid (PLGA) Gel Containing Pegagan Leaves Ethanolic Extract (Centella asiatica L.) Mardiyanto; Elsa Fitria Apriani; Pandu Kalingga Jati
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 10 No. 1 (2023): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v10i12023.103-110

Abstract

Background: Pegagan (Centella asiatica L.) leaves are proven to contain high concentrations of flavonoid compounds as antioxidants. Flavonoids are unstable compounds due to environmental influences such as light, humidity, pH, and oxygen. The stability of pegagan extract was proven to be improved by making the extract into nanoparticle preparations. Objective: This study aims to formulate nanoparticles of pegagan into gel preparations and determine their release ability with the Franz diffusion test using a cellophane membrane compared to pegagan gel not formulated into nanoparticles. Methods: Nanoparticles were made using poly-lactic-co-glycolic acid polymers and then formulated into gels with various concentrations of Carbopol 934, namely 1, 1.5 and 2%. The gel nanoparticles were then subjected to the characterization of the preparation, stability test and release test of the preparation. Results: A concentration of 1% Carbopol 934 provides the best evaluation of gel preparations where the gel produced was homogeneous, pH was around 6.2, viscosity was 3417.12 cPs, spreadability was 5.1 cm, and adhesion was 209.33 seconds. The stability test showed no significant organoleptic and pH changes (p>0.05). The release kinetics model occurs at zero order. F1 has a higher reaction kinetics constant (k) than the other formulations, so drug release occurs faster. Conclusion: The best formula of pegagan (F1) nanoparticle gel was proven to have good physical stability and release ability.
Co-Authors Adik Ahmadi Adik Ahmadi Adik Ahmadi Akhyar Dyni Zakyah Dimas Nur Hidayat Dwi Hardestyariki Fidel Harmanda Prima Fitrya Fitrya Hannan Hanifah Mardiyanto Mardiyanto Mardiyanto Miksusanti Miksusanti Pandu Kalingga Jati Partomuan Simanjuntak Rika Destiana Shelly Thauresia Vini Noviani Vini Noviani Viva Starlista