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All Journal Jurnal Kedokteran Diponegoro Journal of Biomedicine and Translational Research Majalah Obat Tradisional Jurnal Kebidanan Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Yuli Trisetiyono
Department Of Obstetrics And Gynecology, Diponegoro University, Indonesia, Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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The Differences of Malondialdehyde Serum Level, Expression of Tumor Necrosis Factor Alpha and Vascular Endothelial Growth Factor, and the Area of Endometriotic Implants in Administration of Kebar Grass Extract (Biophytum petersianum) and Green Tea Extract (Camelia sinensis) to Mice Yuli Trisetiyono; Noor Pramono; Syarief Thaufik Hidayat; Widjiati Widjiati
Majalah Obat Tradisional Vol 24, No 3 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.45237

Abstract

The pathological pathway of endometriosis remains unclear and involves complex etiologies. Increased oxidative stress is understood to be related to this disease. Oxidative stress produces reactive oxygen species, causes inflammation that is characterized by recruiting lymphocytes and phagocyte activation, produces cytokines that induce oxidation enzyme, and supports epithelium growth. Oxidative stress conjointly will increase angiogenesis and promotes the proliferation of endometriosis tissue within the peritoneal cavity. Kebar grass and green tea contain high antioxidants, are expected to extend antioxidant defense leading to reduced oxidative stress, inflammation, angiogenesis, and reduced endometriosis tissue implants. The objective is to analyze the consequences of Kebar grass and green tea extract to MDA serum level, TNF-α, and VEGF expression, and the area of the endometriotic implants in the mice models.  The study was an experiment designed. It has been conducted within the Department of Obstetrics Gynecology, Faculty of Medicine Diponegoro University and Faculty of Veterinary Medicine Airlangga University. Twenty-one mice were divided into three groups, i.e., the first group of mouse models was given Kebar extract 3 mg/day; the second group was assigned green tea extract 1.1 mg/day; therefore the third group was a control group contains the untreated endometriosis mice. Each treatment was given for fourteen days. MDA serum level was measured by specto-photometric examination, the area of the endometriotic implants was measured by computer tracing technique, whereas TNF-α and VEGF expression of endometriotic implants were measured by IHC using Rammele Scale Index (ImmunoReactive Score). The MDA serum levels of the groups treated with Kebar grass extract and green tea extract were significantly lower than the control group (0.09±0.022 mmol, 0.07±0.019 mmol, and 0.30±0.062 mmol, respectively; p=0.001). TNF-α expression of the groups supplied with each treatment also lower than the control groups (2.43±1.521, 3.66±1.422, and 7.26±2.898, respectively; p=0.002). However, VEGF expression was not significantly different between Kebar grass extract group, green tea group, and the control (4.34±2.402, 4.57±1.998, 7.40±3.495, respectively; p=0.089). Finally, the area of the endometriotic implants of the mice models administered with all treatment was smaller than the control group (0.01±0.025 mm2, 8.76±18.776 mm2, and 34.80±13.079 mm2, respectively; p=0.003). Conclusion: Kebar grass extract, as well as green tea extract administration to endometriosis model mice, resulted in lower MDA serum level and TNF-α expression, smaller the area of endometriotic implants compared, but not resulted in a significant difference of VEGF expression.
Correlation of Weight Gain during Pregnancy and Onset of Lactation Yuli Trisetiyono; Ursheila Haekmatiar
JURNAL KEBIDANAN Vol 9, No 2 (2019): Oktober 2019
Publisher : Politeknik Kesehatan Kementerian Kesehatan Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jkb.v9i2.4909

Abstract

Pregnancy is associated with weight gain. An increase beyond the recommendation of the Institute of Medicine (IOM), has consequences for pregnancy, childbirth, even postpartum. One result of postpartum is a delayed onset of lactation. This study aimed to evaluate the relationship between weight gain during pregnancy and the onset of fluency lactation. The design was observational analytic with a cross-sectional approach which was carried out on postpartum mothers conducted in six primary health centers in the area of Semarang City. The researchers recorded data from the antenatal care book and a questionnaire on the first postpartum visit. The data  was analyzed bivariately using Chi-square test. From 89 subjects, 41 people (46%) experienced under-recommendation weight gain during pregnancy, 32 people (36%) according to recommendations, and 16 people (18%) above recommendations. The onset of fluent lactation since the first 24 hours was found in 28 people (31.5%), 41 people (46.1%) start from day 1-7, and 20 people (22.5%) never went fluently until one week postpartum were. Chi-square test showed that the results were not significant (p=0.215). There was no significant relationship between weight gain during pregnancy and the onset of fluency lactation.
Why Infertility Patients Came Late to Infertility Clinics (Study at Kariadi General Hospital) Rahma Khusnul Khotimah; Besari Adi Pramono; Suharto Suharto; Yuli Trisetiyono
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 6 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i6.30190

Abstract

Background: Infertility is an inability of a spouse to get pregnant within twelve months seeking pregnancy without using any contraception. The duration of infertility affects the chance to get pregnant.Objective: To identify the factors causing infertility patient came late to Polyclinic Merpati RSUP Dr. KariadiMethods: This study was an observational descriptive with a cross-sectional design. The data were obtained from medical records and questionnaires. Twenty-six respondents were infertility patients who met the inclusion and exclusion criteria and came to Polyclinic Merpati RSUP Dr. Kariadi in September 2020.Results: The number of infertility patients in September 2020 was 76 patients, 72,4% of them came to Polyclinic Merpati late. Most people came after being referred from the previous doctors. Three factors causing infertility patients came late were economic factors, a social factor, and another difficulty.Conclusion: Factors causing the late coming of infertility patients were economic factors, a social factor, and another difficulty
The Effect of Zumba on Dysmenorrhea in Students of the Faculty of Medicine, Diponegoro University Humairoh Mutha'alimah; Marijo Marijo; Yuli Trisetiyono; Putri Sekar Wiyati
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 3 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i3.29949

Abstract

Background: Dysmenorrhea is the most common symptom of most menstrual complaints, and has a greater risk of causing disease than any other gynecological complaints. Dysmenorrhea can be accompanied by other symptoms such as sweating, tachycardia, nausea, vomiting, headache, diarrhea and tremors. Dysmenorrhea causes activity limitations which can affect productivity and quality of life of a woman.Objectives: Determine the effects of Zumba on primary dysmenorrhea among female students of the  Faculty of Medicine, Diponegoro University.Method: This study used an analytic observational study with a pretest-middletest-posttest design. A participants of 49 students were divided into 2 groups. The control group (K) was not given the Zumba intervention. Treatment group (P) was given 8-week intervention program with two 60’ sessions per week of Zumba. Data were collected before, during, and after Zumba intervention using a self-administrated dysmenorrhea questionnaire and VAS pain scale.Result: Based on the VAS pain scale and dysmenorrhea questionnaire, the mean value of the control group and treatment group was K: 2,02; 1,92; 2,06; P: 1,98; 1,98; 2,04. Statistical analysis using Friedman tests showed statistically not significant differences (p > 0,05).Conclusion: Zumba exercise did not have a significant difference in reducing dysmenorrhea pain levels.Keyword: Zumba exercise, exercise, primary dysmenorrhea, menstrual pain
Antioxidant Herbs Supplementation Inhibits Endometriosis Extension in Mice Yuli Trisetiyono; Widjiati Widjiati; Syarief Thaufik Hidayat; Noor Pramono
Journal of Biomedicine and Translational Research Vol 5, No 2 (2019): December 2019
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v5i2.4716

Abstract

Background: Increased oxidative stress causes inflammation and increases angiogenesis. It presumed to promote the proliferation of endometriosis tissue. Kebar grass (Biophytum petersianum) and other herbs such as green tea and Cucumis melo, which contain high antioxidants, are expected to decrease oxidative stress, inflammation, angiogenesis, and reduced endometriosis implants.Objective: To investigate the effects of Kebar grass, green tea, and Cucumis melo to malondialdehyde serum, tumor necrosis factor alpha, and vascular endothelial growth factor expression, and the area of the endometriotic implants.Methods: Twenty-eight mice were divided into four groups, i.e., the first group of endometriosis mice was given Kebar grass extract; the second group was assigned green tea extract, the third group was given the combination of Cucumis melo extract–gliadin, and the last containing the untreated endometriosis mice as the control. Each treatment was given for 14 days. The data of MDA serum level, the area of the endometriotic implants, TNF-α, and VEGF expression were collected and analyzed.Results: The MDA serum levels of the groups treated with Kebar grass extract, green tea extract, and Cucumis melo extract – gliadin were significantly lower (p=0.001) than the control group. TNF-α expression of the groups provided with each treatment also lower than the control groups (p=0.002). However, only the administration of the Cucumis melo extract–gliadin resulted in lower VEGF expression compare with the control (p=0.017). Finally, the area of the endometriotic implants of the mice models administered with each treatment was smaller than the control group (p=0.003).Conclusion: Kebar grass as well as green tea and Cucumis melo–gliadin inhibits endometriotic implants extension by decreasing MDA serum and TNF-α expression.
The Suppression Effect of Kebar Extract on Endometriosis Lesion MDA and TNF -a Independent to VEGF A Study in Endometriosis Mice Mode: Efek Supresi Ekstrak Kebar terhadap Lesi Endometriosis, MDA dan TNF-a, tidak Bergantung pada VEGF: Studi pada Model Tikus Endometriosis Yuli Trisetiyono; Noor Pramono; Syarief T. Hidayat; Widjiati Widjiati
Indonesian Journal of Obstetrics and Gynecology Volume 8 No. 1 January 2020
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (620.248 KB) | DOI: 10.32771/inajog.v8i1.1070

Abstract

Background: The pathogenesis of endometriosis remains unclear, and involves multifactorial etiologies. The increase in oxidative stress is known to be associated with this disease. Oxidative stress increases angiogenesis and supports the proliferation of endometriosis tissue in the peritoneal cavity. Kebar grass, a medicinal plant, is expected to increase antioxidant defense resulting in decreased oxidative stress, inflammation, angiogenesis, and reduced endometrial tissue implants. Objective: To investigate the effects of Kebar grass extract administration to MDA serum levels, TNF-a and VEGF expression, and the extension of the endometriotic lesions in mice model. Methods: This study was experimentally designed. It was conducted in the Department of Obstetrics Gynecology, Faculty of Medicine Diponegoro, University and Faculty of Veterinary Medicine, Airlangga University. Twenty-one mice were divided into three groups: the first group is control of 7 untreated endometriosis mice model, the second group consisted of 7 mice injected with leuprolide acetate 1mg/kgBB single dose, and the last group consisted of 7 mice fed with Kebar grass extract 3mg/day for 14 days. MDA serum level was measured by spectrophotometry, TNF-a and VEGF expression by IHC using Rammele Scale Index (ImmunoReactive Score), whereas the extension of the endometriotic lesions was measured using computerize tracing. Results: Both Kebar grass extract and leuprolide acetate administration significantly decrease MDA serum levels in endometriosis mice model, compare with the control group, (0.09±0.02 nmol, 0.11±0.07 nmol, and 0.30±0.06 nmol, respectively; p=0.001). TNF-α expression of the group treated with Kebar grass extract was lower than leuprolide acetate and control group (2.43±1.521 %, 4.86±0.458 %, and 7.26±2.898 %, respectively; p=0.002). However, there was no significant difference in VEGF expression among study groups (4.34±2.40 %, 5.11±1.95 %, and 7.40±3.49 % respectively; p=0.116). Finally, the extension of the endometriotic lesions of the mouse models administered with Kebar grass extract and leuprolide acetate was smaller than the control group (0 mm2, 4.54±7.75 mm2, and 34.80±13.09 mm2 respectively; p=0.005). Conclusion: Kebar grass extract has the effect of decreasing MDA serum levels and reducing TNF-α expression, resulted in smaller endometriotic lesions in mice, even though it does not affect VEGF expression. Keywords: malondialdehyde, tumour necrosis factor alpha, vascular endothelial growth factor, endometriotic lesion, kebar grass extract, endometriosis mouse
Co-Authors Besari Adi Pramono Humairoh Mutha'alimah Marijo Marijo Noor Pramono Noor Pramono Noor Pramono Putri Sekar Wiyati Rahma Khusnul Khotimah Suharto Suharto Syarief T. Hidayat Syarief Thaufik Hidayat Ursheila Haekmatiar Widjiati Widjiati Widjiati Widjiati