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All Journal Majalah Obat Tradisional
Robert Ikechukwu Uroko
Michael Okpara University of Agriculture Umudike, Abia State
Health Professions Medicine & Pharmacology Public Health

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Renal Protective and Lipid Profile Modulatory Effects of Ethanol Extract of Anthocleista vogelii Stem Bark (EASB) in Renal Injury Rats Induced with Carbon-tetrachloride (CCl4) Robert Ikechukwu Uroko; Nnanna Charles Chukwu; Paul Chukwuemaka Nweje-anyalowu; Chinonso Friday Aaron
Majalah Obat Tradisional Vol 26, No 3 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.69540

Abstract

The study evaluated the effects of ethanol extract of Anthocleista vogelii stem bark (EASB) on renal function indices and lipid profile in rats induced renal injury with CCl4. Following a completely randomized experimental design, 30 rats were randomly distributed into 6 groups (n = 5). Group 1 was the normal control, group 2 was the negative control while group 3 was the silymarin control. Groups 4 – 6 were CCl4 induced but treated with 100, 200, and 400 mg/kg EASB/day respectively. The study was conducted using appropriate methods. The results showed that the negative control had a significant (P<0.05) increase in the serum urea, creatinine, cholesterol, triacylglycerol (TAG), low-density lipoprotein (LDL) concentrations, and a significant reduction in the serum high-density lipoprotein (HDL) concentration relative to the normal control. Treatments with EASB lowered the serum creatinine, urea, and TAG concentrations when compared with the negative and silymarin controls respectively. The EASB at 100 mg/kg restored the serum HDL concentration to a normal level but 200 and 400 mg/kg EASB/day caused no significant (P>0.05) increase in the serum HDL concentrations relative to the negative control. The rats treated with EASB had elevated serum LDL and cholesterol concentrations in comparison with the negative and silymarin controls. Treatments with EASB prevented the tubular necrosis, degeneration, and infiltration of inflammatory leucocytes observed in the kidney histomorphology of the negative control. These findings suggest that EASB improves renal function and some lipid profile parameters but could cause dyslipidemia when taken in excess dose.
Evaluation of Antidiabetic Properties of a Polyherbal Extract (ACCBN) on Alloxan-induced Diabetic Rats Robert Ikechukwu Uroko; Amarachi Chike-Ekwughe; Paul Chukwuemeka Nweje-Anyalowu; Chinedu Aguwamba
Majalah Obat Tradisional Vol 31, No 1 (2026)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.99354

Abstract

Diabetes mellitus emanates from a dysfunctional metabolic process and it affects human population globally, and causes a decline in the quality of life and increase in mortality rate due to its complications and adverse effects of the available antidiabetic drugs, thus, there is a need for a better antidiabetic agent. This study assessed the antidiabetic properties of a polyherbal extract (ACCBN) on alloxan-induced diabetic rats to validate its antidiabetic claims in traditional medicine. The diabetic study had 6 groups including normal control, diabetic rats deprived of treatment, diabetic rats administered 5 mg/kg Glibenclamide, and diabetic rats administered 400 and 800 mg/kg ACCBN-extract accordingly and normal rats administered 800 mg/kg ACCBN-extract only. The rats were successfully made diabetic by the administration of alloxan monohydrate intraperitoneally whereas and the rats were treated with either Glibenclamide or ACCBN-extract orally for 28 consecutive days. The acute study of ACCBN-extract indicated lethal dose above 5000 mg/kg. The diabetic rats deprived of treatment showed significantly elevated acute and sub-acute blood glucose levels including significantly elevated glycated haemoglobin concentration and significant decline in the C-peptide and insulin levels relative to the normal control. Diabetic rats administered ACCBN-extract displayed a marked decline in the acute and sub-acute blood glucose levels in comparison to the diabetic rats deprived of treatment. The diabetic rats administered ACCBN-extract displayed a remarkable decline in glycated haemoglobin level and significantly elevated C-peptide and insulin concentrations compared to the diabetic rats deprived of treatment. The outcome revealed that ACCBN-extract possesses sufficient antidiabetic properties and could be effective in the management of diabetes.
Co-Authors Amarachi Chike-Ekwughe Chinedu Aguwamba Chinonso Friday Aaron Nnanna Charles Chukwu Paul Chukwuemaka Nweje-anyalowu Paul Chukwuemeka Nweje-Anyalowu