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All Journal Medicina The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Baskoro Tri Laksono
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Medicine & Pharmacology

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Dampakanemiapadafungsikognitifpasiengeriatri yangdirawatdiRumah Sakit Umum Pusat Sanglah Denpasar Laksono, Baskoro Tri; Kuswardhani, RA Tuty
Medicina Vol 47 No 3 (2016): September 2016
Publisher : Medicina

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (64.606 KB)

Abstract

Anemiamerupakanmasalahyang seringdijumpai padagolongan geriatrikdengankonsekuensi yangserius. Belumbanyak penelitian yang meneliti pengaruh anemia terhadap fungsi kognitif. Penelitianinibertujuanuntukmengetahuihubungan antaraanemiadangangguan kognitif pada pasiengeriatrik yang dirawat di RSUP Sanglah Denpasar.Penelitianinimerupakan studianalisispotong-lintang. Penelitiandilakukanpadapasiengeriatri (usia?60tahun)yangdirawat di BagianPenyakit Dalam RSUP Sanglah Denpasar. Sebanyak121pasien terdaftar dalampenelitian ini.Status anemia dan fungsi kognitif didefinisikan dengan menggunakan kriteria WHOdan mini-mental stateexamination(MMSE). Uji Chi-square atauFisher-exact digunakanuntuk menguji signifikansi antara keduanya.Risikodiperkirakan menggunakanrasioodds (RO) dan interval kepercayaan(IK) 95%. Prevalens anemia dangangguan kognitifpada pasiengeriatrikyangdirawat diRSUPSanglahadalah62,8%dan47,2%. Gangguan kognitiflebih umumterjadi di kalangan perempuan dibanding lelaki (50,88%vs 49,12%) dan pasien usia ?70 tahundibandingkan<70 tahun(63,15%vs 36,84%). Tidakditemukanhubunganyang signifikan antara anemia dangangguan kognitifpadapasiengeriatri (P=0,32).Disimpulkan bahwa tidak adahubungan antaraanemiadangangguankognitifpada pasiengeriatriyang dirawatdiRSUP Sanglah Denpasar.[MEDICINA.2016;50(3):6-9].Anemia isa common problem with serious consequences ingeriatricpatients but the impact of anemia on cognitivefunction has not been extensivelystudied.The aimof this study wasto evaluate the association between anemia andcognitive impairment in hospitalizedgeriatric patients at Sanglah Hospital Denpasar. This was a hospital-basedanalytic cross-sectional study. The data were derived from the medical records ofgeriatricpatients (age?60 years)admitted toDepartment ofInternal Medicine SanglahHospitalDenpsar. A total of 121elderly patients were enrolled.Anemic status and cognitivefunction were defined using WHO-criteria andmini-mental state examination(MMSE)questionnaires, respectively. Chi-square or Fisher-exact test wasused to test thesignificance between 2 proportions.The risk was estimated by usingoddsratio(OR) and 95%confidence interval(CI). The overall-prevalence of anemiaand cognitive impairment among hospitalized elderly patients was 62.8% and 47.2%, respectively. Cognitiveimpairment was more prevalent infemalethan male (50.88% vs. 49.12%) and inpatientswith the age>70 vs<70years(63.15% vs. 36.84%). We found no significantassociationbetween anemia and cognitive impairment ingeriatricpatient (P=0.32). It was concluded that there is no association between anemia and cognitive impairment inhospitalizedgeriatricpatientsatSanglah hospital.[MEDICINA.2016;50(3):6-9].
HBeAg and Anti HBe Status in Patients with Chronic Hepatitis B Infection Haris Widita; Stephanus Gunawan; Baskoro Tri Laksono; Wenny Astuti Achwan; I Gusti Putu Wilusanta; Ketut Mahendra; Herman S Taufiq; Soewignjo Soemohardjo
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 11, NUMBER 3, December 2010
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/1132010125-127

Abstract

Background: Data on HBeAg and anti HBe status in patients with chronic hepatitis B infection are not yet available in Indonesia. This study was done to acquire data on HBeAg and anti HBe status in patients with hepatitis B chronic infection. Method: The material of this study was sera, collected from 105 patients with chronic hepatitis B infection from June to November 2007, divided into four groups of hepatoma, liver cirrhosis, chronic hepatitis B and asymptomatic HBsAg carriers. All sera were examined for HBsAg, HbeAg, anti HBe aside from liver function examinations. The sera consisted of 23 sera of patients with hepatoma, 27 with liver cirrhosis, 12 with chronic hepatitis B, and 43 with HBsAg asymptomatic carriers. Results: From 105 samples, only 18.1% samples were in replicative phase, as shown with the positivity of HBeAg and the negativity of anti-HBe. Sera with negative HbeAg and positive anti-HBe were mainly found in liver cirrhosis (70.73%) and least in chronic hepatitis B (50.00%) Conclusion: The high frequency of HBeAg negative and anti-HBe positive in this study might indicate the possible high frequency of pre core mutation. A study using quantitative HBV DNA should be done to confirm it.   Keywords: HBeAg, anti HBe, chronic hepatitis B
Co-Authors Haris Widita Herman S Taufiq I Gusti Putu Wilusanta Ketut Mahendra R. A.T. Kuswardhani Soewignjo Soemohardjo Stephanus Gunawan Wenny Astuti Achwan