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All Journal e-CliniC Indonesian Journal of Endocrinology Metabolism and Diabetes (InaJEMD)
Yuanita Asri Langi
Unknown Affiliation
Health Professions Medicine & Pharmacology Public Health

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GAMBARAN ELEKTROKARDIOGRAM PADA PASIEN DM TIPE 2 DI POLIKLINIK ENDOKRIN BLU RSUP PROF. DR. R. D. KANDOU MANADO Maradjabessy, Fikri H.; Rampengan, Starry; Langi, Yuanita Asri
e-CliniC Vol 3, No 1 (2015): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.3.1.2015.6745

Abstract

Abstract: There were so many theories and hypotheses association between DM type 2 and cardiovascular diseases (CVD). 5,1 million mortality due to DM (3/4 associated to CVD as DM complication). Early diagnosis of CVD on DM type 2 is crucial, such as ECG sign. The study population, derived from DM type 2 patients visited in Policlinic of Endocrine Prof. Dr. R. D. Kandou Manado hospital for 1 month (September 2014). We design a descriptive retrospective study consisting of non-randomly selected DM type 2 patients medical record with an ECG traces. We evaluated the altered ECG of DM type 2 patients. During the study, there were 53 LAH/LAE traces, coroner vascular diseases 41 traces (18 ischemic myocardium traces, 23 old myocardium infarct traces), bundle branch block (12 LAHB/LAFB, 7 RBBB complete, 3 RBBB incomplete, 1 LBBB traces), 9 LVH traces. Conclusion: there were a significant number of LAH/LAE, coroner vascular diseases and bundle branch block on DM type 2 patient ECG traces in Policlinic of Endocrine Prof. Dr. R. D. Kandou Manado hospital.Keywords: DM type 2, CVD, ECG.Abstrak: Ada begitu banyak teori dan hipotesis tentang hubungan antara DM tipe 2 dan penyakit kardiovaskular (PKV). 5,1 juta kematian akibat DM (3/4 terkait dengan PKV sebagai komplikasi dari DM). Diagnosis dini untuk PKV pada DM tipe 2 sangat penting, seperti gambaran EKG. Populasi penelitian didapatkan dari kunjungan pasien DM tipe 2 di Poliklinik Endokrin BLU RSUP Prof. Dr. R. D. Kandou Manado selama 1 bulan (September 2014). Penelitian di menggunakan desain deskriptif retrospektif terdiri dari rekam medis pasien DM tipe 2 dengan rekam EKG yang dipilih secara non-random. Kami mengevaluasi kelainan EKG pada pasien DM tipe 2. Selama penelitian, ditemukan 53 gambaran LAH/LAE, gangguan pembuluh darah koroner 41 gambaran (18 gambaran iskemik miokard, 23 gambaran infark miokard lama) , blokade cabang berkas 33 gambaran (12 gambaran LAHB / LAFB, 7 gambaran RBBB, 3 gambaran RBBB lnkomplit , 1 gambaran LBBB), dan 9 gambaran LVH. Simpulan: Ditemukan sejumlah besar gambaran EKG untuk LAH/LAE, pembuluh darah koroner, dan blokade cabang berkas pada pasien DM tipe 2 di Poliklinik Endokrin BLU RSUP Prof. Dr, R. D. Kandou Manado.Kata kunci: DM tipe 2, PKV, EKG.
Evaluating the Effect of Fenofibrate Towards the Progression of Diabetic Retinopathy: A Systematic Review Livinia Gabriela Pontoh; Karel Pandelaki; Yuanita Asri Langi; Bisuk Parningotan Sedli; Gloria Notaria Pandelaki
‎ InaJEMD - Indonesian Journal of Endocrinology Metabolic and Diabetes Vol. 2 No. 2 (2025): InaJEMD Vol. 2, No. 2
Publisher : PP PERKENI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.66266/inajemd.v2i2.70

Abstract

The rising prevalence of diabetic retinopathy (DR) among diabetic patients necessitates innovative therapeutic strategies. Fenofibrate, primarily known for its lipid-loweringeffects, has gained attention for its potential role in mitigating DR progression. This study aims to evaluate the efficacy of fenofibrate in reducing the progression of diabetic retinopathy. A comprehensive search was done on three electronic databases, including PubMed, Scopus, and ProQuest up to 3 January 2025. We included all studies that are clinical trials orobservational by design published within the last 15 years. The outcome of interest in this study is the progression or worsening of DR. All eligible studies were assessed using the Cochrane riskof bias tool 2.0 for randomized clinical trials, and the risk of bias in non-randomized studies - of interventions.Result: A total of 5 studies encompassing 2 RCT and 3 retrospective cohort studies with a totalof 250.835 patients, consisting of 101.026 (40.3%) males, with an overall mean age of 64.3 ± 9.5 years old. Based on the risk of bias assessment, all five studies fall in the low to moderate risk ofbias. Four studies show that fenofibrate significantly reduces the risk of DR progression, while one study shows no significant reduction. Two studies also indicate the efficacy of fenofibrate inreducing the development of macular edema. This study solidifies the efficacy of fenofibrate in reducing the risk of DR progression and the development of macular edema.
Co-Authors Bisuk Parningotan Sedli Fikri H. Maradjabessy Gloria Notaria Pandelaki Karel Pandelaki Livinia Gabriela Pontoh Starry Rampengan