The aim of the study is to obtain POC which is one of activator and concentrate to increase the growth of krop lettuce. This study used RAK with 2 handling factors was repeated 3 times. Factor 1 (A): activator, namely: A1 = EM4, A2 = JB3, A3 = EMOL, A4 = ISO and A5 = BK Water; factor 2 (B): POC concentration (B), namely: B1 = 5, B2 = 10, B3 = 15, B4 = 20 and B5 = 25 ml / l water. Then the variance of analyzed and if it is proven to be real, it will be completed with a BNJ Test of 5%. The results of the study: 1) The concentrate of POC which is able to give the best lettuce yield JB3 10 ml / l water (wet weight 289.82 g / plant and dry weight 11,100 g / plant). 2) The results of activator interactions and POC concentrations are able to give the best lettuce yield of JB3 10 ml / l water.