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Kosasih .
PT. Indofarma
Medicine & Pharmacology

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Journal : INDONESIAN JOURNAL OF PHARMACY

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Phosphorylation of pregelatinized maranta starch (Maranta arundinaceae L.) as theophyllin tablet matrix controlled release Effionora Anwar; Dina Yusmarlina; Hasan Rahmat; Kosasih .
Indonesian Journal of Pharmacy Vol 17 No 1, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (207.687 KB) | DOI: 10.14499/indonesianjpharm0iss0pp37-44

Abstract

The present study was carried out to investigate the effect concentration level of pregelatinized and pregelatinized marantha starch phosphate as matrix polymer on the drug release profile. Pregelatinization starch was made by heating suspension of marantha starch with drum dryer. Phosphorylation of pregelatinized maranta starch was prepared by reacting pregelatinized marantha starch with Na2HPO4 and NaHPO4 (2:3). The modified starch product was used as matrices for tablet controlled release separately by direction compression process. Theophyllin was used as a model drug hydrophobic. The dissolution test was carried out separately in 0,1 N HCl (pH 1,8) and in phosphate buffer (pH 7,2), both for 8 hours by using paddle method.The result showed that there was no significant difference (P< 0,05) among the drug release profile from different level concentration of polymeric matrices. The drug release rate was found to be governed by the type and concentration level of polymer in matrix system, polymeric concentration (25%) in matrix, the slower release rate of the drug. Release profile showed a tendency to follow zero-order kinetics from all matrix tablets, and the drug release may be controlled by combination of diffusion and erosion delivery system.Key words: pregelatinized maranta starch phosphate, controlled release, polymeric matrices.
Influence of mechanical and thermal energy on rifampicin Sundani N. Soewandhi; Kosasih .; Rachmat Mauludin; Irvan Khaeruddin
Indonesian Journal of Pharmacy Vol 18 No 3, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (282.244 KB) | DOI: 10.14499/indonesianjpharm0iss0pp124-132

Abstract

The same raw material has opportunity to show different physical properties if it is produced by different industries. For such reason, rifampicin was chosen as a raw materials model, thats obtaining from five resource countries and were obtained from five different suppliers, each coded A, B, C, D and E. Each raw material was handled under tribomechanic and thermal treatment. Mechanical treatment was carried out by using grinding mill at 100 rpm for 30 minutes. Thermal treatment was carried out by oven at 105oC for 2 hours. Transformation occured, was identified by differential scanning calorymetry (DSC), X-ray powder diffraction and dissolution rate. The intrinsic dissolution rate was determined in 900 mL HCl 0,1N oxygen free, using basket and calculated through simultaneously determination method using uv spectrophotometry at λabs.maks. 475 nm. Thermograms of five milled raw material showed endothermic curve at 58oC without obviously melting curve.Thermogram of heated raw material did not show endothermic curve except its melting at 188oC-192oC. Crystallinity indices of the raw materials decreased from C, E, B, A to D. The milled raw materials were mixture of rifampicin II (2%) and amorphous (98%). A and D were mixture of rifampicin form II and fines (amorph). The other samples were only rifampicin form II. All of the raw materials showed different dissolution rates. Rifampicin B,C and D had sameness dissolution rate, whether milled or heated.Key words: Rifampicin II, rifampicin amorphous, DSC, powder X-ray diffraction, dissolution rate
Co-Authors Dina Yusmarlina Effionora Anwar Hasan Rahmat Irvan Khaeruddin Rachmat Mauludin Sundani N. Soewandhi