Garuda - Garba Rujukan Digital

Achmad Fudholi

Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta

Author-ID : 3097071

Medicine & Pharmacology

Published : 2 Documents Claim Missing Document

Claim Missing Document

Articles

Optimization of piroxicam tablet formula using flowlac, avicel and compritol by Simplex Lattice Design Method Tuti Sri Suhesti; Achmad Fudholi
Indonesian Journal of Pharmacy Vol 20 No 3, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Piroksikam is non steroid anti inflammation drug (NSAID) with small dose (10-20 mg daily) with a long time (t1/2) elimination. Piroxicam formulation was expected able to yield a good (quality) tablet to physical characteristic standard. Tablet r component was consisted of Flowlac 100 (filler), Avicel PH-101 (binder) and Compritol 888 ATO (lubricant).The research was done with simplex lattice design (SLD) by using 3 component, i.e. Flowlac (A), Avicel (B), and Compritol (C). Seven formula were needed, I,e, F1 (100 % A), F2 (100 % B), F3 (100 % C), F4 (50 % A and 50 % B), F5 (50 % B and 50 % C), F6 (50 % A and 50 % C),dan F7 (33.33% A, 33.33 % B, 33.33 % C). The optimization parameters of piroxicam tablets were flow rate of the tablet mass, tablet hardness, disintegration time, piroxicam content and the dissolution (C45), on SLD model; equations, contour plots, and superimposed of contour plots were obtained, by which the optimum formula was determined.Based on superimposed contour plot optimum formula was obtained with proportion of Flowlac (89.6 %), Avicel (7.4 %) and Compritol (3 %). The result of flowability was 21.46 g/second; hardness (6.46 kg); disintegration time (6.98 minutes); drug content (10.13 mg) and dissolution C45 (7.35 mg) Interaction of Flowlac-Avicel-Compritol could influence the physical properties and the release profile of tablet. Flowlac was the most dominant factor in increasing flowability, hardness and dissolution of tablet. Compritol was the most dominant factor in increating time of disintegration tablet.Key words: optimization; piroxicam; simplex lattice design.

THE ENFLUENCE OF REPRICIPITATION METHODS PARACETAMOL CRYSTAL USING SOLVENT ETHANOL IN FABRICATION PROCESS ON PHYISICAL PROPERTIES OF TABLET Tri Yulianti; Achmad Fudholi
Indonesian Journal of Pharmacy Vol 12 No 2, 2001
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Paracetamol is the most material drug used in Indonesia. But it’s difficull in processing of the tablet because of capping tendency. The effect of paracetamol reprecipitation by using etanol solven during fabrication process to physical characteristic of tablets of has been studied, and to know the effect of paracetamol. In this studies made five formulas : paracetamol was sprayed by etanol, paracetamol was added filler then sprayed by etanol, paracetamol was added disintegrant then sprayed by elanol, granulating the paracetamol then was sprayed by etanol and paracetamol was without sprayed by etanol. Results showed that granules had been sprayed by etanol before the granulation have characteristic of flow materials was better, the friability of the granules decreased and compressibility of the granules was better. Hardness of tablets relatively increased, the friability of the tablets relative decreased and the disintegration time of tabltets increased. Generally, reprecipitation of paracetamol during the fabrication process, the physical properties of granuls and tablet were better.Key words : paracetamol, reprecipitation, physical properties of tablets

Title

Found 2 Documents
Search

Abstract

Abstract

Title Search

Found 2 Documents Search

Abstract

Abstract

Title

Found 2 Documents
Search