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Supardjan Amir Margono
National Laboratory of Molecule Faculty of Pharmacy, Gadjah Mada University, Yogyakarta Indonesia
Medicine & Pharmacology

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Synthesis of potassium pentagamavunonat-0 using potassium hydroxyde and solvent tertrahydrofuranethanol Supardjan Amir Margono; Ester Yani Verawati
Indonesian Journal of Pharmacy Vol 16 No 4, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.129 KB) | DOI: 10.14499/indonesianjpharm0iss0pp239-245

Abstract

Pentagamavunon-0 (PGV-0) (2,5-bis(4’-hydroxy-3’-methoxy benzy-lidene) cyclopentanone) is a curcumin analogue. To improve its bioavailability it has been succesfully synthesized the Na-salt of this compound. However, sodium may disturb the electrolyte liquid-balance in the body which in turn hypertension. Therefore, the synthesis of potassium pentagamavunonat-0 is attempted. Synthesis has been done using potassium hydroxide as a potassium source, in tetrahydrofuran-ethanol solvent, with molar variations. The result is dipotassium pentagamavunonate-0 (elucidated with IR, 1H-NMR, 13C-NMR and MS spectra), which is more soluble in water and has better stability at high pHs. Molar variations did not show correlation with its yield. The yields are more than 100 %, may be caused by water crystals that contaminate the compound. Key words : pentagamavunon-0, dikalium pentagamavunonat-0, synthesis
Co-Authors Ester Yani Verawati