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All Journal INDONESIAN JOURNAL OF PHARMACY
Mallik Arunabha
Bansal College of Pharmacy, Bhopal, M.P, India 462021
Medicine & Pharmacology

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EVALUATION OF IMMUNOMODULATORY ACTIVITY OF SESBANIA GRANDIFLORA FLOWERS EXTRACT IN MICE Mallik Arunabha; Nayak Satish
Indonesian Journal of Pharmacy Vol 25 No 4, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (838.207 KB) | DOI: 10.14499/indonesianjpharm25iss4pp277

Abstract

The aim of the present study was to investigate the immunomodulatory activity of Sesbania grandiflora on cellular and humoral immunity. Oral administration of the methanolic extract (200 and 400mg/kg) of S. grandiflora flowers, in mice, dose-dependently significantly enhanced the production of circulating antibody titre in mice in response to SRBC. It significantly potentiated the delayed-type hypersensitivity reaction induced by sheep red blood cells (SRBC). Good response was also found towards phagocytosis in carbon clearance assay and prevented myelosuppression in cyclophosphamide drug. Aqueous extract at 250mg/kg dose level failed to show immunomodulatory activity but 500mg/kg of aqueous extract potentiated the activity  however less significantly compared with both dose of methanolic extract. The results obtained in this study indicate that methanolic extract (400mg/kg) of S. grandiflora possesses potential immunomodulatory activity. 
Co-Authors Nayak Satish