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Pudjono .
Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta
Medicine & Pharmacology

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Synthesis of 2,5-dibenzilidin cyclopentanone from benzaldehyde and cyclopentanone by solvent variation Pudjono .; Supardjan .; Tri Irawati
Indonesian Journal of Pharmacy Vol 17 No 1, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (212.603 KB) | DOI: 10.14499/indonesianjpharm0iss0pp45-49

Abstract

The 2,5-dibenzilidine cyclopentanone is a Pentagamavunon-0 analogues (PGV-0) that showed an antiproliferative activity on raji, myeloma and Hella cells. This compound can be synthesized by condensation reaction of a keton and an aldehide by using acid or base as catalyst. The synthesis was carried by reacting cyclopentanone (10 mmol), benzaldehide (20 mmol) and potassium hydroxide 30% (20 mmol) at 5oC, followed by neutralize the reaction product with hydrochloride acid and the compound was obtained by crystalization on CCl4. It showed that rendemen in organic solven: [methanol (96.3 %), ethanol (73.2 %) and isopropanol (67.7%)]. The purity of the product was determined by using melting point and TLC methods . Structural elucidation was carried out by spectroscopic method ( UV-VIS, IR, H1-NMR and MS spectra). It could be concluded that the compound is 2,5-dibenzilidincyclopentanone.Key words: 2,5-dibenzilidincyclopentanone, catalyst, solven.
Co-Authors Supardjan . Tri Irawati