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Sri Mulyani M.
Faculty of Pharmacy Universitas Gadjah Mada Yogyakarta
Medicine & Pharmacology

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ACUTE TOXICITY OF NEW COMPOUNDS 12,13-DIHIDRO--AMYRIN-20,30-en-3-ACETAT ; 12-13-DIHIDRO--AMYRIN-20,30-en-3-ol AND -SITOSTAN-20,30-en-3-ol TO Artemia – Salina Leach Sri Mulyani M.
Indonesian Journal of Pharmacy Vol 12 No 4, 2001
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (180.87 KB) | DOI: 10.14499/indonesianjpharm0iss0pp211-217

Abstract

Acute toxicity assay of new compound from nature resources is very important to be carried out. This research was to perform an acute toxicity assays of new compound from Eupatorium inulifolium H.B.K. Acute toxicity assays was carried out using Brine Shrimp Bioassay method. The result showed that two compounds, 12,13-dihydro--amyrin-20,30-en-3-ol and -sitostan-20,21-en-3-ol displayed toxicity (LC50 < 1000 g/ml), and LC50 of 12,13-dihydro--amyrin-20,30-en-3-acetate was exceeding 1000 g/ml.Key words: 12,13-dihydro--amyrin-20,30-en-3-ol, 12,13-dihydro--amyrin-20,30-en-3-acetate, -sitostan-20,21-en-3-ol, toxicity assay, Artemia salina Leach.
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