Article Per Year (5 Year)
p-Index From 2021 - 2026
0
P-Index
This Author published in this journals
All Journal INDONESIAN JOURNAL OF PHARMACY
Sugiharti .
Nuclear Materials and Radiometric Technology Center, BATAN Bandung
Medicine & Pharmacology

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Biological evaluation of 99mTc-ethambutol for early detection of tuberculosis infection in animal model Rizky Juwita; Sugiharti .; Yana Sumpena; Maula Eka; Sriyani Nanny Kartini
Indonesian Journal of Pharmacy Vol 20 No 2, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (301.631 KB) | DOI: 10.14499/indonesianjpharm0iss0pp55-61

Abstract

Tuberculosis (TB) is the single most infectious disease, killing millions of people globally. Conventional modalities for TB detection many times the disease is diagnosed at delayed stage and can not use for deep seated infection. Therefore, research and development of 99mTc ethambutol to detect and locate TB at an early stage in any anatomical site have been conducted in PTNBRBATAN Bandung. The result of biological evaluation of 99mTc-ethambutol which studied in rat and mice are as follow, biodistribution study showed accumulation of 99mTc-ethambutol in thigh with infected TB at 4 hours post injection via vein with ratio 2.90 target/non target. Blood clearence studies exhibited 44.96 % of 99mTc-ethambutol remain in the blood within 5 minutes of 99mTc-ethambutol administration. Renal clearance study exhibited of 79.52 % 99mTc-ethambutol excreted from the urine after 24 hours. The images were acquired with a Gamma-camera at different time intervals 1.2 3 and 4 hours showed localization of the 99mTc-ethambutol in infected TB animal model. This study showed that 99mTc-ethambutol is a promises radiopharmaceutical to detect TB infection rapidly and has accuracy with high sensitivity and specificity.Key words : radiopharmaceutical, 99mTc-ethambutol, imaging, Mycobacterium tuberculosis.
Co-Authors Maula Eka Rizky Juwita Sriyani Nanny Kartini Yana Sumpena