Sutanto Maduseno
Division of Gastroentero-hepatology, Department of Internal Medicine Faculty of Medicine, University of Gadjah Mada/Dr. Sardjito General Hospital, Jogjakarta

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Reactivation and Flare of Chronic Hepatitis B: Natural History, Diagnosis, Therapy and Prevention Cahyono, Suharjo Broto; Neneng Rasari, Neneng Rasari; Bayupurnama, Putut; Maduseno, Sutanto; Nurdjanah, Siti
Acta Interna The Journal of Internal Medicine Vol 4, No 1 (2014): Acta Interna The Journal Of Internal Medicine
Publisher : Acta Interna The Journal of Internal Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (221.941 KB)

Abstract

ABSTRACTAlmost 30% of the world population has been exposed to hepatitis B virus (HBV) and 400 millionof these are chronically infected. 20–30% of HBsAg carriers may develop reactivation or fl are (acuteexacerbation) of chronic hepatitis B with elevation of biochemical levels, high serum HBV DNA level with orwithout sero-coversion to HBeAg. In countries with intermediate or high endemicity for HBV, compoundedin use cytotoxic or immunosuppressive therapy for the treatment of a wide variety of clinical disease,reactivation or fl are may be the fi rst presentation of HBV infection. Sometime it is diffi cult to differentiatebetween acute hepatitis B and reactivation (fl are). Accurate diagnosis in these cases is very important fordeciding whether to start treatment or not, because acute hepatitis B does not require treatment, whilereactivation or fl are may take benefi t from it. Effort to early detect, to treat and to prevent the reactivationor fl are of chronic hepatitis B is very crucial to reduce morbidity and mortality.Keywords: Reactivation, fl are (acute exacerbation) of chronic hepatitis B, acute hepatitis B, nucleos(t)ideanalogues
Association Between Irregular Eating Behavior, High Fat Intake, and Dyspepsia Syndrome of Male Adolescents at Selected Senior High School in Yogyakarta Nugraha, Adityansyah Irendra; Maduseno, Sutanto; Ratnasari, Neneng
Acta Interna The Journal of Internal Medicine Vol 11, No 1 (2021): Acta Interna The Journal of Internal Medicine
Publisher : Faculty of Medicine Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/actainterna.94632

Abstract

Background. Dyspepsia syndrome is a group of symptoms consisting of epigastric discomfort, nausea, vomiting, bloating, early satiety, abdominal fullness, and belching. Dyspepsia syndrome is common in male adolescents. The causes of dyspepsia are multifactorial, one of the most common is diet and lifestyle changes. Objective. The aim of this study is to determine the association between irregular eating behavior, high fat intake, and dyspepsia syndrome of male adolescents in Yogyakarta senior high school.Methods. A cross-sectional study was performed among 255 male adolescents aged 15-19 years in Yogyakarta senior high school. The data were obtained using Gastrointestinal Symptoms (GIS) questionnaire, irregular eating behavior questionnaire, and Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ). Nominal variables were analyzed statistically by chi-square test and logistic regression test, numerical variables were analyzed by Mann-Whitney test and linear regression test. Result.  Dyspepsia syndrome is positive in 54.9% of the subject. Seventy-four percent of subjects with irregular eating behavior had dyspepsia, p<0.001, OR 3.58 (CI 95%, 2.05-6.26). Seventy-five percent of subjects with high fat intake had dyspepsia, p= 0.005, OR 2.86 (CI 95%, 1.33-6.15). The median GIS score of the high fat and normal fat intake group are two to one (p=0.005). Median GIS scores of irregular and regular eating behavior groups are two to zero (p<0.001). The coefficient of determination (R2) from multivariate analysis is 0.065.Conclusion. There is a significant association between eating irregularities and high fat consumption patterns with the incidence of dyspepsia syndrome in male adolescents in Yogyakarta high school.