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All Journal The International Journal of Tropical Veterinary and Biomedical Research
Bakhtiar Bakhtiar
Department of Pediatrics, Faculty of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Combination of Isoniazid and Rifampin for the Prevention of Failure of Standard Therapy for Latent Tuberculosis Infection in Children: Evidence Base Case Report Bakhtiar Bakhtiar; Hirsa Angriani
The International Journal of Tropical Veterinary and Biomedical Research Vol 6, No 1 (2021): Vol. 6 (1) May 2021
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (82.365 KB) | DOI: 10.21157/ijtvbr.v6i1.23040

Abstract

Tuberculosis (TB) control program in children is carried out with three strategies: finding and treating adult TB cases (as a source of transmission), treating latent TB infection, and administering the BCG vaccine. There is a high risk of transmission in children in close contact and living at home with adult patients. After Mycobacterium is inhaled through the respiratory tract, then the body's resistance to Mycobacterium tuberculosis occurs. Furthermore, there are two possibilities: only TB infection occurs, or the child has TB disease. We report one case: a boy, age four years, diagnosed with latent TB infection. This diagnosis is based on the findings of the 13 mm tuberculin test (positive). There is a history of contact with adult TB patients. On physical examination, no abnormalities were found. Likewise, the chest X-ray examination also found no abnormalities. Due to the diagnosis of latent TB infection, prophylaxis with Isoniazid was planned for six months. In the first month, the child still wants to take medication according to the rules. However, entering the second month, children sometimes do not want to take medication. This situation raises concerns about the possibility of therapy failure. His mother was very worried about this condition. Therefore, doctors offer to provide a combination pattern of therapy in isoniazid with rifampicin, with a span of 3 months. Standard therapy with INH alone was discontinued. This therapeutic decision was based on a study that combined INH with rifampin for three months gave better results than single prophylactic therapy with INH.
Incidence of Respiratory Distress Syndrome and Its Associated Factors among Preterm Neonates: Study from West Java Tertiary Hospital Irman Permana; Raden Tina Dewi Judistiani; Bakhtiar Bakhtiar; Ayu Alia; Tetty Yuniati; Budi Setiabudiawan
The International Journal of Tropical Veterinary and Biomedical Research Vol 7, No 1 (2022): Vol. 7 (1) May 2022
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (156.332 KB) | DOI: 10.21157/ijtvbr.v7i1.27043

Abstract

Respiratory distress syndrome (RDS) or hyaline membrane disease is the most frequent cause of respiratory failure and mortality in preterm infants. As a result, many infants are brought to a neonatal intensive care unit (NICU). There may also be other factors that affect the incidence rate of RDS as well. Our research goals are to find out the incidence rate of RDS among three preterm groups and its related factors. In a cross-sectional-descriptive analytical study, newborn data was gathered and assessed by using hospital medical records. One hundred forty-two preterm infants with gestational age ≤ 36 weeks were hospitalized in the NICU. All participants were divided into three groups: extremely preterm ( 28 weeks), very preterm (28 to 32 weeks), and moderate-to-late preterm (32 to 36 weeks). The frequency of RDS and some related factors were compared among three groups. Finally, we analyzed the relationship between variables by SPSS statistics software version 19. The level of significance was considered P 0.05. Respiratory distress syndrome was observed in 64.68% of all participants; RDS is more common in infants within 28-32 weeks of gestation (81%), while infants with 28 weeks of gestation and 33-36 weeks of gestation have lower rates (50% and 52 Our study shows a positive correlation between birthweight and RDS as well as between birthweight and gestational age. (P value: 0.001, 0.003). Infants between 28 to 32 gestational age have a higher risk of RDS. The risk of RDS also increases in low birth weight and male infants.
Incidence of Respiratory Distress Syndrome and Its Associated Factors among Preterm Neonates: Study from West Java Tertiary Hospital Irman Permana; Raden Tina Dewi Judistiani; Bakhtiar Bakhtiar; Ayu Alia; Tetty Yuniati; Budi Setiabudiawan
The International Journal of Tropical Veterinary and Biomedical Research Vol 7, No 1 (2022): Vol. 7 (1) May 2022
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v7i1.27043

Abstract

Respiratory distress syndrome (RDS) or hyaline membrane disease is the most frequent cause of respiratory failure and mortality in preterm infants. As a result, many infants are brought to a neonatal intensive care unit (NICU). There may also be other factors that affect the incidence rate of RDS as well. Our research goals are to find out the incidence rate of RDS among three preterm groups and its related factors. In a cross-sectional-descriptive analytical study, newborn data was gathered and assessed by using hospital medical records. One hundred forty-two preterm infants with gestational age ≤ 36 weeks were hospitalized in the NICU. All participants were divided into three groups: extremely preterm ( 28 weeks), very preterm (28 to 32 weeks), and moderate-to-late preterm (32 to 36 weeks). The frequency of RDS and some related factors were compared among three groups. Finally, we analyzed the relationship between variables by SPSS statistics software version 19. The level of significance was considered P 0.05. Respiratory distress syndrome was observed in 64.68% of all participants; RDS is more common in infants within 28-32 weeks of gestation (81%), while infants with 28 weeks of gestation and 33-36 weeks of gestation have lower rates (50% and 52 Our study shows a positive correlation between birthweight and RDS as well as between birthweight and gestational age. (P value: 0.001, 0.003). Infants between 28 to 32 gestational age have a higher risk of RDS. The risk of RDS also increases in low birth weight and male infants.
Co-Authors Ayu Alia Budi Setiabudiawan Hirsa Angriani Irman Permana Raden Tina Dewi Judistiani Tetty Yuniati