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All Journal UNEJ e-Proceeding Grouper: Jurnal Ilmiah Perikanan
Yora Utami
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Immunology & microbiology Veterinary

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Arcangelisia flava LEAVES ETHANOLIC EXTRACT SUPPRESSES CANCER CELL LINES VIA NON APOPTOTIC PATHWAY Endah Puspitasari; Dian Agung Pangaribowo; Yora Utami; Ika Yanuar Isparnaning
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Arcangelisia flava is a potential candidate to bedeveloped as cancer chemoprevention agent. A.flava was proven to exhibit antioxidant and cytotoxicactivity against MCF-7 breast cancer cell line. Theseability were suggested to be related to its alkaloidcontent: berberine, palmatine, and jatrorrhizine(Keawpradub et al., 2005). Although this plant isstated as a rarely found species (Koran Jakarta,2012), we could find it abudantly in Meru BetiriNational Park, Jember.Our previous studies showed that A. flava leavesincrease the immune system in doxorubicin-treatedrats (Puspitasari et al., 2014b) with no signs oftoxicity based on sub chronic toxicity assay(Puspitasari et al., 2014a). The A. flava leavesethanolic extract (EEAfL) had been proven to havecytotoxic activity on HeLa, MCF-7, and WiDr cancercell lines with the IC50 value of 467 + 70; 136 + 17;and 213 + 79 μg/ml, respectively. The activity wasselective on MCF-7 and WiDr, but not likely on HeLacell line (Puspitasari et al., 2015).OBJECTIVESThis study was conducted to determine whether thecytotoxic activity of EEAfL was occur via apoptotic ornecrotic pathway using flowcytometry annexin VFITCmethod. The concentration used for the assaywere concentration approx. the IC50 and the IC75based on previous study (Puspitasari et al., 2015).
Identification of the Use of Noni Leaf Extract (Morinda Citrifolia) in Blood Observations in Gouramy Fish (Osphronemus Gouramy) Infected with Aeromonas Hydrophila Yora Utami; Nurkholifah Dwi Rahayu; Fajar Rudy Hartono
Grouper Vol. 15 No. 2 (2024): Grouper : Jurnal Ilmiah Perikanan
Publisher : Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/grouper.v15i2.295

Abstract

Aeromonas hydrophila is a facultative anaerobic bacteria, namely bacteria that can grow in conditions with or without oxygen. One of the diseases that fish farmers fear is red spot disease or Motile Aeromonas Septicemia (MAS) which is caused by A. hydrophila. Therefore, it is necessary to use alternative materials that can be used to eliminate A. hydrophila, one of which is by using herbal medicines. A natural ingredient that can be used to treat fish attacked by bacteria is noni leaves (Morinda citrifolia). The aim of this research was to determine the active compound content in noni leaf extract (M. citrifolia) and the use of noni leaf extract (M. citrifolia) on the hematology of gouramy fish. The results of the Column Chromatography (KK) test showed that the crude extract of noni leaves was positive for alkaloids, saponins, triterpemoids and flavonoids. And in the GC-MS test, it was discovered that the most dominant phenolic compounds contained in noni leaf extract. The results of hemotological data analysis based on the ANOVA test showed that administration of noni leaf extract (M. citrifolia) had a significant effect (p<0.05) on hematocrit, erythrocytes, leukocytes and hemoglobin. Based on the results of observations of the parameters seen, treatment of gouramy fish (Osphronemus gouramy) infected with A. hydrophila bacteria at an optimal dose of 360 ppm.
Co-Authors Dian Agung Pangaribowo Endah Puspitasari Fajar Rudy Hartono Ika Yanuar Isparnaning Nurkholifah Dwi Rahayu