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All Journal UNEJ e-Proceeding Jurnal Kesehatan Islam : Islamic Health Journal
Eka Deddy Irawan
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Medicine & Pharmacology Public Health

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FORMULATION AND OPTIMIZATION OF CARBOPOL AND ETHYL CELLULOSE AS FLOATING-MUCOADHESIVE SYSTEM OF DILTIAZEM HYDROCHLORIDE TABLET BY FACTORIAL DESIGN Eka Deddy Irawan; Lusia Oktora Ruma Kumala Sari; Andreas Henry Prasetyo
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Abstract

Hypertension is a degenerative disease that eachyear has increased the number of patients. Numberof patients in Indonesia is estimated at 15 millionpeople. Nearly 50% of patients suffering fromhypertension are not aware that tends to be severehypertension (Syahrini et al., 2012).Diltiazem Hydrochloride (HCl) is an antihypertensivedrug used 3-4 times a day with doses of 30-60 mg(UBM Medica, 2012). Diltiazem HCl has a half life of3-5 hours (Sweetman, 2009) with the mainabsorption area in the upper stomach (Kapil et al.,2012) that can be formulated into sustained releasedosage gastro retentive system.The system created is a combination of floatingmucoadhesive.The combination of these systems isexpected to overcome the shortcomings of thesystem when used alone. Floating system floats overthe surface of gastric contents when the stomach isfull but at the time stomach is emptied and thetablet reaches the pylorus the bouyancy of thedosage may be decreased. If the stomach is full,mucodhesive dosage form not properly adheres maybe passage the pylorus due to peristalticmovements of the stomach (Gaykar et al., 2013).Polymer is one of the essential ingredients toproduce a floating-mucoadhesive system that meetsthe requirements. The polymer used is acombination of Carbopol and ethyl cellulose. Thecombination of hydrophilic and hydrophobicpolymers proved able to control the rate of drugrelease with high solubility (Nanjwade et al., 2011).
OPTIMASI MORINGA GUM DAN POLIVINIL ALKOHOL DALAM SEDIAAN MUCOADHESIVE BUCCAL FILM DILTIAZEM HIDROKLORIDA Nani Sukmawati; Lusia Oktora Ruma Kumala Sari; Eka Deddy Irawan
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 13 No. 1 (2024): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v13i1.21718

Abstract

Abstract. Diltiazem Hydrochloride (HCl) is commonly used in hypertension therapy for its beneficial effects, such as reducing blood vessel pressure resistance and relaxing the heart muscles. In an in-vivo study, Diltiazem HCl is known to be decrease by 60% of its bioavailability due to first-pass metabolism. Thus, it is necessary to develop a new administration route, some of which is buccal drug delivery route in mucoadhesive buccal film. Moringa gum is a polyuronide polymer with a hydroxyl group in its side chains, giving the potential use as a mucoadhesive polymer. However, it has poor folding endurance and its release kinetics study has not been investigated. Polyvinyl alcohol (PVA) is a water-soluble polymer with hydroxyl side chain. PVA is known for its high tensile strength and flexibility, though it can be affected by humidity. The aim of this research is to determine the right amount of moringa gum and PVA to obtain a film with good physical characteristics and mucoadhesive residence time. In this study, the optimization of moringa gum and PVA was carried out using factorial design. Mucoadhesive buccal film was prepared by solvent casting method, the films were later evaluated and the obtained responses were analyzed by Software Design Expert 11.0.0. The optimization result shows the film containing the amount of moringa gum 2% and PVA 5% can produce the optimum formula. The mucoadhesive buccal film formula has surface pH of 6.083, mucoadhesive residence time of 445.055 min, swelling index of 4.067, and 87.9913% drug release in in-vitro drug release study after 420 min following the Higuchi model release kinetics. Therefore, it can be concluded that the obtained optimum formula of mucoadhesive buccal film can be used in the preparation of mucoadhesive buccal film Diltiazem HCl.. Kata Kunci: Hypertension; Diltiazem HCl; Mucoadhesive buccal film; Moringa gum; PVA.
Co-Authors Andreas Henry Prasetyo Lusia Oktora Ruma Kumala Sari Nani Sukmawati