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Mahendra Rai
Department of Biotechnology, Sant Gadge Baba Amravati University, Amravati-444602, Maharashtra, India
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Antifungal effect of cumin essential oil alone and in combination with antifungal drugs SAHADEO PATIL; PANKAJ MAKNIKAR; SUSHILKUMAR WANKHADE; CHANDRAKIRAN UKESH; MAHENDRA RAI
Nusantara Bioscience Vol. 7 No. 1 (2015)
Publisher : Smujo International

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/nusbiosci/n070110

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Abstract. Patil S, Maknikar P, Wankhade S, Ukesh C, Rai M. 2015. Antifungal effect of cumin essential oil alone and in combination with antifungal drugs. Nusantara Bioscience 7: 55-59. We report evaluation of antifungal activity of cumin seed oil and its pharmacological interactions when used in combination with some of the widely used conventional antifungal drugs using CLSI broth microdilution, agar disc diffusion and checkerboard microtitre assay against Candida. The essential oil was obtained from cumin seeds using hydrodistillation technique and was later evaluated for the presence of major chemical constituents present in it using gas chromatography and mass spectrometry (GC-MS) assay. The GC-MS assay revealed the abundance of ?-terpinene (35.42%) followed by p-cymene (30.72%). The agar disc diffusion assay demonstrated highly potent antifungal effect against Candida species. Moreover, the combination of cumin essential oil (CEO) with conventional antifungal drugs was found to reduce the individual MIC of antifungal drug suggesting the occurrence of synergistic interactions. Therefore, the therapy involving combinations of CEO and conventional antifungal drugs can be used for reducing the toxicity induced by antifungal drugs and at the same time enhancing their antifungal efficacy in controlling the infections caused due to Candida species.
Review: Mycoendophytes in medicinal plants: Diversity and bioactivities MAHENDRA RAI; ANIKET GADE; DNYANESHWAR RATHOD; MUDASIR DAR; AJIT VARMA
Nusantara Bioscience Vol. 4 No. 2 (2012)
Publisher : Smujo International

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/nusbiosci/n040207

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Abstract. Rai M, Gade A, Rathod D, Dar M, Varma A. 2012. Review: Mycoendophytes in medicinal plants: Diversity and bioactivities. Nusantara Bioscience 4: 86-96. Endophytes are microorganisms that reside in internal tissues of living plants without causing any negative effect. These offer tremendous potential for the exploitation of novel and eco-friendly secondary metabolites used in medicine, the pharmaceutical industry and agriculture. The present review is focused on diversity of endophytes, current national and international bioactive secondary metabolite scenario and future prospects. Endophytic fungi as novel source of potentially useful medicinal compounds are discussed along with the need to search for new and more effective agents from endophytes to combat disease problems
Co-Authors Ajit Varma ANIKET GADE CHANDRAKIRAN UKESH DNYANESHWAR RATHOD MUDASIR DAR PANKAJ MAKNIKAR SAHADEO PATIL SUSHILKUMAR WANKHADE